Hari K. Koul, M.Sc., PhD, FACN, FASN
hkoul@lsuhsc.edu
Professor, Biochemistry & Molecular Biology, and Urology
Dr. Koul’s laboratory is investigating:
A) the structure and function of Prostate Derived Ets Transcription factor (PDEF/
SPDEF) in prostate and breast cancer progression, therapy resistance and cancer health
disparities. Current studies are identifying the molecular mechanisms by which PDEF
regulates gene expression with specific emphasis on identification of proteins that
interact with PDEF using proteomics approaches. The lab is also investigating regulation
of PDEF expression with special emphasis on YY1, EZH2 and DNMT.
B) Role of deregulated protein synthesis in solid tumors with special emphasis on
the regulation of cap-dependent translation by EIF4G.
C) Developing small molecular therapeutics using a library of compounds based on tetrandrine
and its derivatives.
D) Biology of prostate and breast cancer disparities in African American Subjects,
with special emphasis on transcription factors and epigenetic drivers.