Education

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Degree:
Doctor of Medicine
Universidad Nacional Autónoma de Mexico, Mexico City, Mexico

Residency:
Anatomic Pathology
Hospital General de Mexico & Universidad Nacional Autónoma de Mexico, Mexico City, Mexico

Fellowships:
Neuropathology
Thomas Jefferson University, Philadelphia, Pennsylvania

Neurovirology
Temple University School of Medicine, Philadelphia, Pennsylvania

Affiliated Hospitals

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University Medical Center - New Orleans
Louisiana Cancer Research Center

Publications

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Mohammad MA, Kumar N, Ghosh S, Paysse A, Leonardi C, Pilli VS, Duhaylungsod ML, Lazartigues E, Polania-Villanueva D, Nouman S, Barrios LA, Chattopadhyay R, Yasmin R, Guilbeau A, Kumar M, Nguyen T, Zabaleta J, Li L, Del Valle L, Barbier MT, Majumder S, Mosnier LO, and Majumder R. (2025). Estrogen and obesity synergistically suppress Protein S via HIF1a, enhancing thrombotic potential. Journal of Clinical Investigation; 135 (22); e193976 [PMID: 41243971]

Ingraham C, Polania Villanueva D, Macaluso A, Tramulta A, Vittori C, Hunter JJ, Rak M, Claudio PP, Ibrahim MA, Del Valle L, Peruzzi F, Jursic B, and Reiss K. (2025). Bypassing blood-brain barrier and glucose dependency of anti-Glioblastoma drug candidates targeting mitochondrial respiration. Journal of Cellular Physiology; 240 (7): e70062 [PMID: 40665659]

Hunter JJ, Del Valle L, Peruzzi F, and Reiss K. (2025). Cardiolipin dysregulation in Glioblastoma; effects on mitochondrial function, tumor cell death and sensitivity to mitochondria-targeting drugs. Journal of Cellular Physiology; 240 (5): e70045 [PMID: 40372980]

Prouse T, Larter K, Ghosh S, Kumar N, Mohammad M, Del Valle L, Majumder R, and Majumder S. (2025). Exogenous Protein S inhibits pancreatic ductal adenocarcinoma. Thrombosis Research; 245: 109,233 [PMID: 39626470]

Howard CM, De Carlo F, Sitta J, Kirven I, Dobbins GC, Penfornis P, Barbier M, Del Valle L, Larsen CT, Schutt EG, Li R, and Claudio PP. (2024). Microbubble-protected oncolytic virotherapy targeted by sonoporation induces tumor necrosis and T-lymphocyte infiltration in humanized mice bearing triple-negative breast cancer. International Journal of Molecular Sciences; 25 (24): 13,697 [PMID: 39769460]

Puttalingaiah RT, Dean MJ, Zheng L Philbrook P, Wyczechowska D, Kayes T, Del Valle L, Danos D, and Sanchez-Pino MD. (2024). Excess potassium promotes autophagy to maintain the immunosuppressive capacity of Myeloid-Derived Suppressor Cells independent of Arginase 1. Cells; 13 (20): 1736 [PMID: 39451254]

Monticone G, Huang Z, Hewins P, Cook T, Mirzalieva O, King B, Larter K, Miller-Esminger T, Sanchez-Pino MD, Foster T, Nichols O, Ramsay A, Majumder S, Wyczechowska D, Tauzier D, Gravois E, Crabtree JS, Garai J, Li L, Zabaleta J, Barbier MT, Del Valle L, Jurado KA, and Miele L. (2024). Novel immunomodulatory properties of Adenosine analogs promote their antiviral activity against SARS-CoV-2. EMBO Reports; 25 (8): 3547-3573 [PMID: 39009832]

Hossain F, Ucar DA, Monticone G, Ran Y, Majumder S, Larter K, Luu H, Wyczechowska D, Heidari S, Xu K, Shanthalingam S, Matossian M, Xi Y, Burow M, Collins-Burow BM, Del Valle L, Hicks C, Zabaleta J, Golde TE, Osborne BA, and Miele L. (2023). Sulindac Sulfide as a non-immune suppressive gamma-secretase modulator to target Triple-Negative Breast Cancer. Frontiers in Immunology: 14: 1244159 [PMID: 37901240]

Barbier MT, and Del Valle L. (2023). Co-Detection of EBV and Human Polyomavirus JCPyV in case of HIV-related Multifocal Primary Central Nervous System Diffuse Large B-cell Lymphoma. Viruses; 15 (3): 755 [PMID: 36992464]

Khreefa Z, Barbier MT, Koksal AR, Love G, and Del Valle L. (2023). Pathogenesis and mechanisms of SARS-CoV-2 infection in the intestine, liver, and pancreas. Cells; 12 (2): 262 [PMID: 36672197]

Dean M, Ochoa JB, Sanchez-Pino MD, Zabaleta J, Garai J, Del Valle L, Wyczechowska D, Buckner Baiamonte LB, Philbrook P, Majumder R, Vander Heide RS, Dunkenberger L, Thyllur RP, Nossaman B, Roberts WM, Chapple AG, Wu J, Hicks C, Collins J, Luke B, Johnson R, Koul HK, Rees CA, Morris CR, García-Diaz J, and Ochoa AC. (2021). Severe COVID-19 is characterized by an impaired Type I Interferon response and elevated levels of Arginase producing Granulocytic Myeloid Derived Suppressor Cells. Frontiers in Immunology; 12: 695972 [PMID: 34341659]

Del Valle L, Dai L, Cao Y, Lin HY, Lin Z, Chen J, Post SR, Xu Z, and Qin Z. (2021). Role of EIF4G1 network in Non-Small Cell Lung Cancers (NSCLC) cell survival and disease progression. Journal of Cellular and Molecular Medicine; 25 (6): 2795-2805 [PMID: 33539648]

Del Valle L, and Khalili K. (2021). Induction of brain tumors by the Archetype strain of human neurotropic JCPyV in a transgenic mouse model. Viruses; 13 (2): 162 [PMID: 33499370]

Chen J, Goyal N, Dai L, Lin Z, Del Valle L, Zabaleta J, Liu J, Post S, Foroozesh M, and Qin Z. (2020). Developing new Ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated Lymphoma.  Blood; 136 (19): 2175-2187 [PMID: 32518949]

Del Valle L, Sweet T, Parker-Stuckhoff A, Perez-Liz G, and Piña-Oviedo S. (2020). JCPyV T-Antigen activation the anti-apoptotic Survivin promoter; it’s role in the development of Progressive Multifocal Leukoencephalopathy. Viruses; 12 (11): E1253 [PMID: 33153187]

Hoang VT, Matossian MD, Ucar DA, Elliot S, La J, Wright MK, Burks HE, Perles A, Hossain F, King CT, Browning VE, Bursavich J, Fang F, Del Valle L, Bhatt AB, Cavanaugh JE, Flaherty PT, Anbalagan M, Rowan BG, Bratton MR, Nephew KP, Miele L, Collins-Burow BM, Martin EC, and Burow ME. (2020). ERK5 is required for tumor growth and maintenance through regulation of the extracellular matrix in Triple Negative Breast Cancer.  Frontiers in Oncology; 10: 1164 [PMID: 32850332]

Del Valle L, and Piña-Oviedo S. (2019). Human Polyomavirus JCPyV and its role in Progressive Multifocal Leukoencephalopathy and Oncogenesis.  Frontiers in Oncology; 9: 711 [PMID: 31440465]

Stalinska J, Zimolag E, Panovich NA, Zapata A, Lassak A, Rak M, Dean M, Ucar-Bilyeu DA, Wyczechowska D, Culicchia F, Marrero L, Del Valle L, Sarkaria JN, Peruzzi F, Jusic BS, and Reiss K. (2019). Chemically modified variants of Fenofibrate with high anti-Glioblastoma efficacy.  Translational Oncology; 12 (7): 895-907 [PMID: 31078963]

Sabol RA, Bowles AC, Côté A, Wise R, O’Donnell B, Matossian MD, Hossain FM, Burks HE, Del Valle L, Miele L, Collins-Burow BM, Burow ME, and Bunell BA. (2019). Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models.  Breast Cancer Research; 21 (1); 67 [PMID: 31118047]

Dai L, Del Valle L, Miley W, Whitby D, Ochoa AC, Flemington EK, and Qin Z. (2018). Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s Sarcoma development.  Oncogene; 37 (33): 4534-4545 [PMID: 29743595]

Dai L, Qiao J, Del Valle L, and Qin Z. (2018). KSHV co-infection regulates HPV16+ cervical cancer cells pathogenesis in vitro and in vivo.  American Journal of Cancer Research; 8 (4): 708-714 [PMID: 29736315]

Lassak A, Dean M, Wyczechowska D, Wilk A, Marrero L, Trillo-Tinoco J, Boulares AH, Sarkaria JN, Del Valle L, Peruzzi F, and Ochoa A, and Reiss K. (2018). Molecular and structural traits of Insulin Receptor Substrate 1/LC3 nuclear structures and their role in autophagy control and tumor cell survival.  Molecular and Cellular Biology; 38 (10): e00608-17 [PMID: 29483302]

Al-Khami AA, Zheng L, Del Valle L, Hossain F, Wyczechowska D, Zabaleta J, Sanchez MD, Dean MJ, Rodriguez PC, and Ochoa AC. (2017). Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells.  OncoImmunology; 6, (10): e1344804 [PMID: 29123954]

Al-Khami AA, Ghonim MA, Del Valle L, Ibba SV, Zheng L, Pyakurel K, Okpechi SC, Garay J, Wyczechowska D, Sanchez-Pino MD, Rodriguez PC, Boulares AH, and Ochoa AC. (2017). Fueling the mechanisms of Asthma: increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.  Clinical & Experimental Allergy; 47 (9): 1170-1184 [PMID: 28456994]

Bonsignore L, Passelli K, Pelzer C, Perroud M, Konrad A, Thurau M, Stürzl M, Dai L, Trillo-Tinoco J, Del Valle L, Qin Z, and Thome M. (2017). A role for MALT1 activity in Kaposi's sarcoma-associated herpesvirus latency and growth of primary effusion lymphoma.  Leukemia; 31 (3): 614-624 [PMID: 27538487]

Maggi EC, Trillo-Tinoco J, Parker Struckhoff A, Vijayaraghavan J, Del Valle L, and Crabtree JS. (2016). Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.  Oncogenesis; 5 (8): e257 [PMID: 27548814]

Dai L, Qiao J, Nguyen D, Struckhoff AP, Doyle L, Bonstaff K, Del Valle L, Parsons C, Toole BP, Renne R, and Qin Z. (2016). Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi's sarcoma-associated herpesvirus.  Oncotarget; 7 (9): 10,459-10,471 [PMID: 26859574]

Garai J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, and Zabaleta J. (2016). The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in the development of mucous metaplasia in mice.  Cancer Letters; 371 (1): 90-98 [PMID: 26639196]

Dai L, Trillo-Tinoco J, Cao Y, Bonstaff KP, Doyle L, Del Valle L, Whitby D, Parsons CH, Reiss K, Zabaleta J, and Qin Z. (2015) Targeting HGF/c-MET induces cell cycle arrest, DNA damage and apoptosis for primary effusion lymphoma.  Blood; 126 (26): 2821-2831 [PMID: 26531163]

Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, Del Valle L, Trillo-Tinoco J, Rodriguez PC, and Ochoa AC. (2015). Inhibition of fatty acid oxidation modulates immunosuppressive functions of Myeloid-Derived Suppressor Cells and enhances cancer therapies.  Cancer Immunology Research; 3 (11): 1236-1247 [PMID: 26025381]

Thevenot PT, Sierra RA, Raber PL, Al-Khami AA, Trillo-Tinoco J, Zarrei P, Ochoa AC, Cui Y, Del Valle L, and Rodriguez PC. (2014). The stress-response sensor Chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors.  Immunity; 41 (3): 389-401 [PMID: 25238096]

Ripple M, Parker Struckhoff A, Trillo-Tinoco J, Li L, Margolin DA, McGoey R, and Del Valle L. (2014). Activation of c-Myc and Cyclin D1 by JCV T-Antigen and b-Catenin in Colon Cancer.  PLoS One; 9 (9): e106257 [PMID: 25229241]

Sierra RA, Thevenot P, Raber PL, Cui Y, Parsons C, Ochoa AC, Trillo-Tinoco J, Del Valle L, and Rodriguez PC. (2014). Rescue of Notch-1 signaling in antigen specific CD8+ T cells overcomes tumor-induced T cell suppression and enhances immunotherapy in cancer.  Cancer Immunology Research; 2 (8): 800-811 [PMID: 24830414]

Struckoff AP, Rana MK, Kher SS, Burow ME, Hagan JL, Del Valle L, and Worthylake RA. (2013). PDZ-RhoGEF (PRG) is essential for CXCR4-driven Breast tumor cell motility through spatial regulation of RhoA.  Journal of Cell Science; 126 (19): 4514-4526 [PMID: 23868972]

Guo G, Marrero L, Rodriguez P, Del Valle L, Ochoa A, and Cui Y. (2013). Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid-like stromal network.  Cancer Research; 73 (6): 1668-1675 [PMID: 23319800]

Morrow K, Hernandez CP, Raber P, Del Valle L, Wilk AM, Majumdar S, Wyczechowska DD, Velasco C, Cole J, Reiss K, and Rodriguez PC. (2013). Anti-leukemic mechanisms of Pegylated Arginase in acute lymphoblastic T cell leukemia.  Leukemia; 27 (3): 569-577 [PMID: 22926702]

Dela Cruz FN, Giannitti F, Li L, Woods LW, Del Valle L, Delwart E, and Pesavento PA. (2013).  Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States.  Emerging Infectious Diseases; 19 (1): 77-84 [PMID: 23260029]

Reiss K, Del Valle L, Lassak A, and Trojanek J. (2012). Nuclear IRS-1 and Cancer. Journal of Cellular Physiology; 227 (8): 2992-3000 [PMID: 22454254]

Rom S, Pacifici M, Pasiatore G, Aprea S, Waligorska A, Del Valle L, and Peruzzi F. (2011). HIV-Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction. BBA: Molecular Cell Research; 1813 (10): 1836-1844 [PMID: 21745501]

Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, De Laurenzi V, Turco MC, and Rosati A. (2011). BAG3 protein is overexpressed in human Glioblastoma and is a potential target for therapy.  American Journal of Pathology; 178 (6): 2504-2512 [PMID: 21561597]

Langford D, Baron D, Joy J, Del Valle L, and Shack J. (2011). Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation.  Psychoneuroendocrinology; 36 (5): 710-719 [PMID: 21115295]

Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, and Persidsky Y. (2010). Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: Implications for HIV-1 Encephalitis.  Journal of Neuroscience; 30 (28): 9454-9464 [PMID: 20631174]

Del Valle L, and Khalili K. (2010). Detection of JC virus proteins, T-Antigen and Agnoprotein in human tumor tissue arrays.  Journal of Medical Virology; 82 (5): 806-811 [PMID: 20336718]

Del Valle L, Piña-Oviedo S, Perez-Liz G, Augelli BJ, Azizi A, Khalili K, Gordon J, and Krynska B. (2010). Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics.  Cancer Biology & Therapy; 9 (4): 286-297 [PMID: 20190567]

Rom I, Rom S, Passiatore G, Pacifici M, Radhakrishnan S, Del Valle L, Piña-Oviedo S, Khalili K, Eletto D, and Peruzzi F. (2010). CCL8/MCP2 is a target for mir-146a in HIV-1 infected human microglial cells. FASEB Journal; 24 (7): 2292-2300 [PMID: 20181935]

Gualco E, Urbanska K, Perez-Liz G, Sweet T, Peruzzi F, Reiss K, and Del Valle L. (2010). IGF-1R dependent activation of Survivin is required for T-Antigen mediated protection from apoptosis and proliferation of neural progenitors.  Cell Death & Differentiation; 17 (3): 439-451 [PMID: 19834489]

Riolfi M, Ferla R, Del Valle L, Piña-Oviedo S, Scolaro L, Micciolo R, Guidi M, Terrasi M, Cetto GL, and Surmacz E. (2010).  Leptin and its Receptor are overexpressed in Brain Tumors and correlate with the degree of malignancy.  Brain Pathology; 20 (2): 481-489 [PMID: 19775291]

Piña-Oviedo S, Khalili K, and Del Valle L. (2009). Hypoxia Inducible Factor-1 alpha activation of the JCV promoter: role in the pathogenesis of Progressive Multifocal Leukoencephalopathy.  Acta Neuropathologica (Berl); 118 (2): 235-247 [PMID: 19360424]

Piña-Oviedo S, Del Valle L, Baquera-Heredia J, and Ortiz-Hidalgo C. (2009). Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineural cell origin.  Journal of the Peripheral Nervous System; 14 (1): 22-26 [PMID: 19335536]

Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, Del Valle L, Khalili K and Reiss K. (2009). Estrogen Receptor b-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in Medulloblastoma.  Journal of Cellular Physiology; 219 (2): 392-401 [PMID: 19117011]

Del Valle L, Schwartzman RJ, and Alexander G. (2009). Spinal cord histopathological alterations in a patient with longstanding Complex Regional Pain Syndrome.  Brain, Behavior, and Immunity; 23 (1): 85-91 [PMID: 18786633]

Perez-Liz G, Del Valle L, Gentilella A, Croul S, and Khalili K. (2008). Detection of JC Virus DNA fragments but not proteins in normal brain tissue.  Annals of Neurology; 64 (4): 379-387 [PMID: 18688812]

Woodruff-Pak DS, Agelan A, and Del Valle L. (2007).  A rabbit model of Alzheimer’s disease: valid at neuropathological, cognitive, and therapeutic levels.  Journal of Alzheimer’s Disease; 11 (3): 371-383 [PMID: 17851187]

Piña-Oviedo S, Urbanska K, Radhakrishnan S, Sweet T, Reiss K, Khalili K, and Del Valle L. (2007). Effects of JC Virus Infection on Anti-Apoptotic Protein Survivin in Progressive Multifocal Leukoencephalopathy.  American Journal of Pathology; 170 (4): 1291-1304 [PMID: 17392168]

Darbinyan A, White MK, Akan S, Radhakrishnan S, Del Valle L, Amini S, and Khalili K. (2007). Alterations of DNA damage repair pathways resulting from JCV infection.  Virology; 364 (1): 73-86 [PMID: 17368705]

Aprea S, Del Valle L, Mameli G, Sawaya BE, Khalili K, and Peruzzi F. (2006).  Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal dependent-degradation of microtubule-associated protein 2 and neuronal damage.  Journal of Neuroscience; 26 (15): 4054-4062 [PMID: 16611822]

Piña-Oviedo S, Enam S, De León-Bojorque B, Cuesta-Mejías T, Ortiz-Hidalgo C, White M, Khalili K, and Del Valle L. (2006).  Glioblastoma multiforme with small cell neuronal-like component: association with human neurotropic JC virus.  Acta Neuropathologica (Berl); 111 (4): 388-396 [PMID: 16557392]

Del Valle L, and Piña-Oviedo S. (2005).  HIV disorders of the brain; pathology and pathogenesis.  Frontiers in Bioscience; 11: 718-732 [PMID: 16146764]

Trojanek J, Ho T, Del Valle L, Wang JY, Darbinyan A, Nowicki M, Croul S, Skorski T, Khalili K, and Reiss K. (2006).  T-antigen from human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.  Journal of Cell Physiology; 206 (1): 35-46 [PMID: 15965906]

Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, and Fults DW. (2004).  Sonic hedgehog and Insulin-like Growth Factor signaling synergize to induce Medulloblastoma formation from nestin-expressing neural progenitors in mice.  Oncogene; 23 (36): 6156-6162 [PMID: 15195141]

Shollar D, Del Valle L, Khalili K, and Gordon J. (2004).  JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumor.  Oncogene; 23 (32): 5459-5467 [PMID: 15133494]

Del Valle L, Enam S, Lara C, Miklossy J, Khalili K, and Gordon J. (2004).  Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus genome.  Journal of Virology; 78 (7): 3462-3469 [PMID: 15016869]

Enam S, Sweet T, Amini S, Khalili K, and Del Valle L. (2004).  Evidence for involvement of transforming growth factor beta1 signaling pathway in activation of JC virus in human immunodeficiency virus 1-associated Progressive Multifocal Leukoencephalopathy.  Archives of Pathology and Laboratory Medicine; 128 (3): 282-291 [PMID: 14987161]

Katsetos CD, Del Valle L, Legido A, deChadarévian JP, Geddes JF, and Mörk SJ. (2003).  On the neuroblastic nature of cerebellar Medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak.  Acta Neuropathologica (Berlin); 105 (1): 1-13 [PMID: 12471454]

Del Valle L, Enam S, Lara C, Ortiz-Hidalgo C, Katsetos CD, and Khalili K. (2002).  Detection of JC polyomavirus DNA sequences and cellular localization of T-Antigen and Agnoprotein in oligodendrogliomas.  Clinical Cancer Research; 8 (11): 3332-3340 [PMID: 12429619]

Del Valle L, Enam S, Lassak A, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin-like Growth Factor 1 receptor activity in human medulloblastomas.  Clinical Cancer Research; 8 (6): 1822-1830 [PMID: 12060623]

Del Valle L, Delbue S, Gordon J, Enam S, Croul S, Ferrante P, and Khalili K. (2002).  Expression of JC virus T-Antigen in a multiple sclerosis patient with a Glioblastoma multiforme.  Neurology; 58 (6): 895-900 [PMID: 11914404]

Lassak A, Del Valle L, Peruzzi F, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen.  Journal of Biological Chemistry; 277 (19): 17,231-17,238 [PMID: 11877394]

Del Valle L, Gordon J, Enam S, Delbue S, Croul S, Abraham S, Radhakrishnan S, Assimakopoulou M, Katsetos CD, and Khalili K. (2002).  Expression of human neurotropic polyomavirus JCV late gene product Agnoprotein in human medulloblastoma.  Journal of the National Cancer Institute; 94 (4): 267-273 [PMID: 11854388]

Del Valle L, Behring J, Lorenzana C, Giordano A, Khalili K, and Croul S. (2001).  Expression of a polyoma virus oncoprotein and tumor suppressor proteins in medulloblastomas.  Journal of Clinical Pathology; Molecular Pathology; 54 (5): 331-337 [PMID: 11577176]

Del Valle L, Gordon J, Assimakopoulou M, Katsetos CD, Geedes J, Varakis JN, Croul S, and Khalili K. (2001).  Detection of JC virus DNA sequences and expression of the viral regulatory protein T-Antigen in tumors of the central nervous system.  Cancer Research; 61 (10): 4287-4293 [PMID: 11358858]

Del Valle L, Azizi A, Krynska B, Enam S, Croul S, and Khalili K. (2000).  Reactivation of human neurotropic JC virus expressing oncogenic protein, in a recurrent Glioblastoma multiforme.  Annals of Neurology; 48 (6): 932-936 [PMID: 11117551]

Gordon J, Del Valle L, Otte J, and Khalili K. (2000). Pituitary neoplasia induced by expression of human neurotropic Polyomavirus, JCV, early genome in transgenic mice.  Oncogene; 19 (42): 4840-4846 [PMID: 11039901]

Krynska B, Del Valle L, Gordon J, Otte J, Croul S, and Khalili K. (2000). Identification of a novel p53 mutation in JCV-induced mouse Medulloblastoma.  Virology; 274 (1): 65-74 [PMID: 10936089]

Del Valle L, Croul S, Morgello S, Amini S, Rappaport J, and Khalili K. (2000).  Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with Progressive Multifocal Leukoencephalopathy.  Journal of Neurovirology; 6 (3): 221-228 [PMID: 10878711]

Bonvetch R, Croul S, Richardson MW, Lorenzana C, Del Valle L, Alexander GM, Amini S, Morgello S, Khalili K, and Rappaport J. (1999). Role of HIV-1 Tat and CC chemokine MIP-1 a in the pathogenesis of HIV associated Central Nervous System disorders.  Journal of NeuroVirology; 5 (6): 685-694 [PMID: 10602409]

Krynska B, Del Valle L, Croul S, Gordon J, Katsetos CD, Carbone M, Giordano A, and Khalili K. (1999).  Detection of human neurotropic JC virus DNA sequences and expression of the viral oncogenic protein in pediatric medulloblastomas.  Proceedings of the National Academy of Sciences USA; 96 (20): 11,519-11,524 [PMID: 10500209]

Complete list if Publications (PubMed):
https://www.ncbi.nlm.nih.gov/myncbi/luis.del%20valle.1/bibliography/public/

 

Research

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Viral Oncogenesis
Polyomaviruses (JCPyV & Merkel Cell PyV)
Mechanisms of Demyelination in Progressive Multifocal Leukoencephalopathy
Glial Brain Tumors
Medulloblastomas