HER2NEU CHROMOGRANIN CYCLIN D1 CYTOKERATIN-HMW

C-erb-bB-2 (Her 2 neu)

 CONTROL TISSUE: carcinoma of breast(2+)
MAIN DISTRIBUTION: tumor cells
TYPE OF STAINING: Membranous
APPLICATION: Carcinoma of breast
Scoring is done evaluating the percent of invasive cells that stain positive. 0=negative or cytoplasmic staining. 1+ = partial cell membrane staining of more or equal 10% of cells. 2+=Circumferential staining of the tumor cell membrane with a thin rim, involving more or equal 10% of tumor cells. 3+ =as with 2+ but the tumor cell membrane is a thick rim of darkly stained cell membrane.
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Chromogranin A

 CONTROL TISSUE: Pancreas
MAIN DISTRIBUTION: Islets
TYPE OF STAINING: Cytoplasmic
APPLICATION: Neuroendocrine cells
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Cyclin D1(BCL-1)

 CONTROL TISSUE: Mantle cell lymphoma
MAIN DISTRIBUTION: Tumor cell and nuclei of endothelial cells
TYPE OF STAINING: Nuclear is required for specificity.
APPLICATION: mantle cells lymphomas. Hairy cell leukemia and some myelomas are positive.

 
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Cytokeratin - High Molecular Weight/903

CONTROL TISSUE: Prostate or skin
MAIN DISTRIBUTION: Basal cells or epidermis
TYPE OF STAINING: Cytoplasmic
APPLICATION: Basal cells of prostate are absent in prostatic carcinomas. Squamous cell carcinoma
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