PUBLICATIONS of Dr. Nichols 

(In chronological order)

Pollock, J.A., Assaf, A., Peretz, A., Nichols, C.D., Mojet, M.H., Hardie, R.C., and Minke, B. (1995). TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors. Journal of Neuroscience15, 3747–3760. PMID: 7751943.

Loreto, E.L., Zaha, A., Nichols, C., Pollock, J.A., and Valente, V.L. (1998). Characterization of a hypermutable strain of Drosophila simulans. Cell Mol Life Sci54, 1283–1290. PMID: 9849620.

Behan, K.J., Nichols, C.D., Cheung, T.L., Farlow, A., Hogan, B.M., Batterham, P., and Pollock, J.A. (2002). Yan regulates Lozenge during Drosophila eye development. Dev Genes Evol212, 267–276. PMID: 12111211.

Nichols, C.D., and Sanders-Bush, E. (2002). A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain. Neuropsychopharmacology 26, 634–642. PMID: 11927188.

Nichols, C.D., Ronesi, J., Pratt, W., and Sanders-Bush, E. (2002). Hallucinogens and Drosophila: linking serotonin receptor activation to behavior. Neuroscience115, 979–984. PMID: 12435434.

Nichols, C.D., Garcia, E.E., and Sanders-Bush, E. (2003). Dynamic changes in prefrontal cortex gene expression following lysergic acid diethylamide administration. Brain Res Mol Brain Res111, 182–188. PMID: 12654518.

Nichols, C.D., and Sanders-Bush, E. (2004). Molecular genetic responses to lysergic acid diethylamide include transcriptional activation of MAP kinase phosphatase-1, C/EBP-beta and ILAD-1, a novel gene with homology to arrestins. J Neurochem90, 576–584. PMID: 15255935.

Jackson Behan, K., Fair, J., Singh, S., Bogwitz, M., Perry, T., Grubor, V., Cunningham, F., Nichols, C.D., Cheung, T.L., Batterham, P., et al. (2005). Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development. Dev Genes Evol 215, 423–435. PMID: 15868204.

Nichols, C.D. (2006). Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery. Pharmacol Ther 112, 677–700. PMID: 16935347.

Marvanova, M., and Nichols, C.D. (2007). Identification of neuroprotective compounds of caenorhabditis elegans dopaminergic neurons against 6-OHDA. J Mol Neurosci 31, 127–137. PMID: 17478886.

Nichols, C.D. (2007). 5-HT2 receptors in Drosophila are expressed in the brain and modulate aspects of circadian behaviors. Dev Neurobiol67, 752–763. PMID: 17443822.

Zerfaoui, M., Suzuki, Y., Naura, A.S., Hans, C.P., Nichols, C., and Boulares, A.H. (2008). Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction. Cell Signal20, 186–194. PMCID: PMC2278030.

Nichols, D.E., and Nichols, C.D. (2008). Serotonin receptors. Chem. Rev.108, 1614–1641. PMID: 18476671

Yu, B., Becnel, J., Zerfaoui, M., Rohatgi, R., Boulares, A.H., and Nichols, C.D. (2008). Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther327, 316–323. PMID: 18708586

Johnson, O., Becnel, J., and Nichols, C.D. (2008). Serotonin 5-HT2 and 5-HT1A-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster. Neuroscience 4:1292-1300. PMCID: PMC2747308.

Duvernay, M.T., Dong, C., Zhang, X., Zhou, F., Nichols, C.D., and Wu, G. (2009). Anterograde trafficking of G protein-coupled receptors: function of the C-terminal F(X)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol 75, 751–761. PMCID: PMC2684921.

Nichols, C.D., and Roth, B.L. (2009). Engineered G-protein Coupled Receptors are Powerful Tools to Investigate Biological Processes and Behaviors. Front Mol Neurosci 2, 16. PMCID: PMC2773177.

Nichols, C.D. (2009). Serotonin 5-HT(2A) Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases. Cardiovasc Psychiatry Neurol 2009, 475108. PMCID: PMC2790184.

Marona-Lewicka, D., Nichols, C.D., and Nichols, D.E. (2011). An animal model of schizophrenia based on chronic LSD administration: Old idea, new results. Neuropharmacology. 61:503-512. PMCID: PMC3110609.

Becnel, J., Johnson, O., Luo, J., Nässel, D.R., and Nichols, C.D. (2011). The Serotonin 5-HT7Dro Receptor Is Expressed in the Brain of Drosophila, and Is Essential for Normal Courtship and Mating. PLoS ONE6, e20800. PMCID: PMC3107233.

Pandey, U.B., and Nichols, C.D. (2011). Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery. Pharmacological Reviews63, 411–436. PMCID: PMC3082451.

Johnson, O., Becnel, J., and Nichols, C.D. (2011). Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. Neuroscience. 192:371-81. PMCID: PMC3166404.

Luo, J., Becnel, J., Nichols, C.D., and Nässel, D.R. (2012). Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor. Cell Mol Life Sci. Feb;69(3):471-84. PMID: 21818550.

Nichols, C.D., Becnel, J., and Pandey, U.B. (2012). Methods to Assay Drosophila Behavior. Journal of Visualized Experiments : J. Vis. Exp. (61) e3795. PMID: 22433384.

Dong, C., Nichols, C.D., Guo, J., Huang, W., Lambert, N.A., and Wu, G. (2012). A triple arg motif mediates α(2B)-adrenergic receptor interaction with Sec24C/D and export. Traffic13, 857–868. PMCID: PMC3350609.

Daigle, J.G., Lanson, Jr, N.A.,  Smith, R., Casci, I., Maltare, A., Monaghan, J., Nichols , C.D., Kryndushkin, D., Shewmaker, F., and Pandey, U.B. (2013). RNA binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations. Hum. Mol. Genet 22(6):1193-205. PMCID: PMC3578413.

Becnel, J., Johnson, O., Tran, Majeed, Z., V., Yu, B., Roth, B.L., Cooper, R.L., and C.D. Nichols (2013). A pharmacogenetic approach for robustly controlling behavior, neuronal signaling, and physiology in Drosophila. Cell Reports. 4(5): 1049-1059. PMCID: PMC3889141.

Nau*, F.J., Yu*, B., , Martin, D., and Nichols, C.D. (2013) Serotonin 5-HT2A Receptor Activation Blocks TNF-α Mediated Inflammation in vivo. PLoS One. 8 (10):e75426. PMCID: PMC3788795.

Majeed, Z.R., Nichols, C.D., and Cooper, R.L. (2013). 5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics. Journal of Applied Physiology. 115 (11):1656-65. PMCID: PMC3882742.

Martin D.A., Marona-Lewicka D., Nichols D.E., and Nichols CD (2014). Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. Neuropharmacology 83: 1-8. PMCID: PMC3788795

Nau, F.J., Miller, J., Saravia, J., Ahlert, T., Yu, B., Happel, K., Cormier, S.A., and Nichols, C.D. (2015). Serotonin 5-HT2 receptor activation prevents allergic asthma in a mouse model. Am J Physiol Lung Cell Mol Physiol. Jan 15;308(2):L191-8. PMCID: PMC4338939.

Martin, D.A., and Nichols, C.D. (2016) Psychedelics recruit multiple cellular types and produce complex transcriptional responses within the brain. EBioMedicine (a new journal from a collaboration between Cell and Lancet). 11, 262-277.

Martin, D.A., and Nichols, C.D. (2017). The effects of hallucinogens on gene expression. Behavioral Neurobiology of Hallucinogens, Entactogens, and Psychomimetics / Current topics in Behavioral Neurosciences. (Vol. 20, pp. 92–22). Berlin, Heidelberg: Springer Berlin Heidelberg.

Martin, D., Xu, J., Porretta, C., & Nichols, C. D. (2017). Neurocytometry: Flow Cytometric Sorting of Specific Neuronal Populations from Human and Rodent Brain. ACS Chemical Neuroscience, 8(2), 356–367.

Nichols, D. E., Johnson, M. W., & Nichols, C.D. (2017). Psychedelics as Medicines: An Emerging New Paradigm. Clinical Pharmacology & Therapeutics, 101(2), 209–219.

Kayzar, E.J., Nichols C.D., Gainetdinov, R.R., Nichols, D.E., and Kalueff, A.V. (2017) Psychedelic Drugs in Biomedicine. Trends in Pharmacological Sciences. in press.


Book Chapters :

Nichols, C.D. and E. Sanders-Bush (2001). Serotonin receptor signaling and hallucinogenic drug action. Heffter Review of Psychedelic Research, 2: 73-79

Nichols, C.D. and E. Sanders-Bush (2003). Neuropharmacology: Serotonin. Encyclopedia of the Neurological Sciences. v.4, 245-248, Academic Press.

Sanders-Bush, E. and, C.D. Nichols (2004). Serotonin Receptors and Neurotransmission. Primer on the Autonomic Nervous System. Second Edition. Elsevier Science, 93-96.

Nass, R., and C.D.Nichols (2007). Invertebrates as powerful genetic models for human neurodegenerative diseases. Handbook of Contemporary Neuropharmacology, ed. David Sibley, Israel Hanin, and Michael Kuhar. John Wiley and Sons, 567-588

 Nichols, C.D. (2014). Neuropharmacology: Serotonin. Encyclopedia of the Neurological Sciences. Academic Press, Second edition.

Nichols, C.D. (2015). Visualization of the serotonin system in Drosophila brain: Immunofluorescence and confocal microscopy. Neuromethods: Serotonin Receptor Technologies. Springer. 95:191-203

Nichols, C.D. (2015). Drosophila melanogaster. Discoveries in Modern Science: Exploration, Invention, Technology. MacMillan.

Nichols, C.D., Becnel, J. (2015). DREADDs in Drosophila. Springer 108: 147-158.

Nichols, C.D. (2015). Drosophila Models in Therapeutic Drug Discovery. Extensions: Lessons from Drosophila. Springer p.213-225.

Nichols, C.D. (2016). Schizophrenia modeling using LSD. The Neuropathology of drug addictions and substance misuse. Academic Press.