Jiaxi Xu, PhD

Jiaxi 2016

 

Position

Postdoctoral Associate (Lazartigues' Laboratory)

Lab Number

MEB 5219

Phone

(504) 568-3211

E-mail

jxu3@lsuhsc.edu

Education

B.S. in Pharmacy, China Pharmaceutical University, China

M.S. in Pharmacology, Hebei Medical University, China.

PhD in Pharmacology, Hebei Medical University, China.

Research interests

1. Investigating the role of the renin-angiotensin system in neurodegenerative diseases.

2. Investigating the signaling pathways of angiotensin converting enzyme 2 (ACE2) in the central regulation of blood pressure.

Research Support

American Heart Association Postdoctoral Fellowship

07/01/2015 – 06/30/2017

“Role of ADAM17 in neurogenic hypertension”

Selected Publications

  1. Xu J. , Mukerjee S., Silva-Alves C.R.A., Carvalho-Galvão A., Cruz J.C., Balarini C.M., Braga V.A., Lazartigues E. & França-Silva  M.S. A disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems (Invited Review) Front. Physiol. 2016; 7:469. PMID: 27803674. PMCID: PMC5067531.
  2. Xu J. , Sriramula S., Xia H., Moreno-Walton L., Culicchia F., Domenig O., Poglitsch M. & Lazartigues E.Clinical relevance and role of neuronal AT1 receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension. Circ. Res. 2017; 121(1):43-55. PMID: 28512108. PMCID: PMC5507353.
  3. Xu J. , Sriramula S. & Lazartigues E.Excessive glutamate stimulation impairs ACE2 activity through ADAM17-mediated shedding in cultured cortical neurons. Cell. Mol. Neurobiol. 2018; [Epub ahead of print].
  4. Carvalho-Galvão A.S., Ogunlade B., Xu J., Silva-Alves C.R.A., Mendes-Júnior L.G., Guimarães D.D., Cruz J.C., Queiroz T.M., Balarini C.M.; Braga V.A., Filipeanu C.M., Lazartigues E.  & França-Silva M.S. Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats. Clin. Sci. (Lond) 2018; 132:1513-1527.

Awards

2015-17    Postdoctoral Fellowship, American Heart Association greater Southeast Affiliate

2016    Poster Award from the Gordon Research Conference on Angiotensin

2016    Research Recognition Award from the Neural Control and Autonomic Regulation section of the American physiological Society

2017    VWR-sponsored Experimental Biology Trainee Award from the NCAR section of the American Physiological Society

2018    Best oral presentation from the Gordon Research Conference on Angiotensin

2018    Michael J. Brody Young Investigator Award from the NCAR section of the American Physiological Society