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Albrechet-Souza, Lucas

Instructor – Research

1901 Perdido Street, Room 7242

New Orleans, LA 70112

Phone: 504-568-6191

Fax:     504-568-6158

ldesou@lsuhsc.edu

Degrees

M.S., Ph.D.

Bio

B.S. in Biology                    University of Sao Paulo, Brazil

B.S. in Biology Education   University of Sao Paulo, Brazil

M.S. in Psychobiology        University of Sao Paulo, Brazil

Ph.D. in Psychobiology      University of Sao Paulo, Brazil

Postdoctoral training in Neuropsychopharmacology, University of Sao Paulo, Brazil

Postdoctoral training in Psychopharmacology     Tufts University

Postdoctoral training in Neuropharmacology       LSUHSC-NO

Research Interests

My research has focused on investigating changes in brain mechanisms induced by traumatic stress in rodents, with emphasis in the involvement of CRF and endocannabinoids in discrete brain areas on stress-induced dysregulated behavior, including anxiety, avoidance and escalation of alcohol consumption.

Selected Publications

Newman EL, Albrechet-Souza L, Andrew PM, Auld JG, Burk KC, Hwa LS, Zhang EY, Debold JF, Miczek KA. Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism. Psychopharmacology (Berlin) 235: 1808-20, 2018.

Vasconcelos M, Stein DJ, Albrechet-Souza L, Miczek KA, De Almeida RMM. Recovery of stress-impaired social behavior by an antagonist of the CRF binding protein, CRF6-33, in the bed nucleus of the stria terminalis of male rats. Behavioural Brain Research 17: 30337-46, 2018.

Albrechet-Souza L, Viola TW, Grassi-Oliveira R, Miczek KA, De Almeida RMM. Corticotropin releasing factor in the bed nucleus of the stria terminalis in socially defeated and non-stressed mice with a history of chronic alcohol intake. Frontiers in Pharmacology 8: 762, 2017.

Albrechet-Souza L, Hwa LS, Han X, Zhang EY, DeBold JF, Miczek KA. Corticotropin releasing factor binding protein and CRF 2 receptors in the ventral tegmental area: modulation of ethanol binge drinking in C57BL/6J mice. Alcoholism, Clinical and Experimental Research 39: 1609-18, 2015.

Han X, Albrechet-Souza L, Doyle MR, Shimamoto A, DeBold JF, Miczek KA. Social stress and escalated drug self-administration in mice II. Cocaine and dopamine in the nucleus accumbens. Psychopharmacology (Berlin) 232: 1003-10, 2014.

Boyson CO, Holly EN, Shimamoto A, Albrechet-Souza L, Weiner LA, Debold JF, Miczek KA. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. The Journal of Neuroscience 34: 6659-67, 2014.

Albrechet-Souza L, Carvalho MC, Brandao ML. D1-like receptors in the nucleus accumbens shell regulate the expression of contextual fear conditioning and activity of the anterior cingulate cortex in rats. International Journal of Neuropsychopharmacology 16: 1045-57, 2013.

Borelli KG, Albrechet-Souza L, Fedoce AG, Fabri DS, Resstel LB, Brandao ML. Conditioned fear is modulated by CRF mechanisms in the periaqueductal gray columns. Hormones and Behavior 63: 791-9, 2013.

Additional Info