Selected Publications

Kim, H., Abd Elmageed, Z.Y., Ju, J., Naura, A. S., Abdel-Mageed A.B., Varughese, S., Paul, D., Alahari, S.K., Catling, A., Kim, J.G., and Boulares, H. Pdzk1 is a novel factor in breast cancer that is regulated by IGF-1R and promotes estrogen-mediated growth (2013) Molecular Medicine, (EPub ahead of print)

Jain, P., Baranwal, S., Dong, S., Struckoff, A., Worthylake, R., and Alahari, S.K.,  Integrin-binding protein Nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells (2013) Journal of Biological Chemistry, 31: 15495- 15509.

Kuijil, C*., Pilli, M*., Alahari, S.K.,*., (*equal contribution)., Janssen, H., Khoo, P., Ervin, K. E, Celero, M., Jonnalagadda, S., Scheller, RH., Neefjes, J., Junutula, J. Rac and Rab GTPases dual effector Nischarin facilitates survival of intracellular bacteria (2013) EMBO Journal , 32: 713-727.

Jin, L., Yu, Q., Wesseley, O., Marcusson, E., and Alahari, S.K., Her2 oncogene regulates the expression of miR-27b and 23b, which repress Nischarin to control tumor growth (2013) Cancer Research, 73: 2884-2896.

Alahari, S.K., Regulation of metastasis by microRNAs, a book chapter published in microRNA in cancer, Springer, 2012.

Jain, P., Worthylake, R. A., and Alahari, S.K.,. Quantitative analysis of random migration of cells using time-lapse video microscopy (2011). Journal of Visualized Experiments, 13: e3585.

Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer. Somesh Baranwal, Yanfang Wang, Rajamani Rathinam, Jason Lee, Lianjin Jin, Robin McGoey, Yuliya Pylayeva, Filippo Giancotti, Gerard C. Blobe and Alahari SK.JNCI J Natl Cancer Inst (2011) doi: 10.1093/jnci/djr350 First published online: September 14, 2011

Role of Rho GTPases and their regulators in cancer progression. Rathinam R, Berrier A, Alahari SK. Front Biosci. 2011 Jun 1;17:2561-71.PMID:21622195 [PubMed - in process] Related citations

Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis. Baranwal S, Alahari SK.Curr Drug Targets. 2011 Jul 1;12(8):1194-201.PMID:21561416[PubMed - in process]Related citations

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis. Yanfang Wang, Sylvia Shenouda, Somesh Baranwal, Rajamani Rathinam, Prachi Jain, Lili Bao, Siddhartha Hazari, Srikanta Dash and Alahari SK. Molecular Cancer, 2011 (IN PRESS).

Breast cancer stem cells: A new challenge for breast cancer treatment Jain P, Alahari SK Frontiers in Bioscience 16, 1824-1832, (1 January, 2011)

Integrin mediated function of Rab GTPases in cancer progression Subramani D and Alahari SKMolecular Cancer 2010, 9:312 (9 December 2010)

miRNA control of tumor cell invasion and metastasis.Baranwal S, Alahari SK. Int J Cancer. Oct 29. (2010)

Important role of integrins in the cancer biology. Rathinam R, Alahari SK.Cancer Metastasis Rev. Jan 30 .(2010)

Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Alphonso A, Alahari SK.Neoplasia.Dec;11(12):1264-71. (2009)

MicroRNA function in cancer; Oncogene or a tumor suppressor. Shenouda, S.K. and Alahari S KCancer and Metastasis reviews. (In Press) (2009)

ST14 (suppression of tumorigenicity 14) gene is a target for miR-27b, and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation. Wang Y, Rathinam R, Walch A, Alahari SK. J Biol Chem. (2009)

Molecular mechanisms controlling E-cadherin expression in breast cancer Baranwal, S and Alahari S KBiochemical and Biophysical Research Communications. 384: 6-11B 2009 Jun 19;384(1):6-11. (2009)

Ding Y, Milosavljevic T, Alahari S K . Nischarin inhibits LIM Kinase to regulate Cofilin phosphorylation and Cell Invasion. Mol Cell Biol. Mar 10 (2008)

Alahari S K, Reddig, P., Juliano, R.L. The integrin binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J, 23: 2777-2788 (2004)

Juliano, R.L., Reddig, P.J., Alahari S K, Edin, M.L., Howe, A.K., and Aplin, A.E., Integrin Regulation of Cell Signaling and Motility.Biochem., Society Transactions 32: 443-446 (2004)

Alahari S K and H. Nasrallah : A Membrane proximal region of alpha-5 integrin is essential for its interaction with Nischarin. Biochemical Journal 15: 449-457 (2004)

Alahari S K: Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Exp. Cell Res. 288: 415-424 (2002)

Alahari SK, Reddig, P., Juliano, R.L. Biological aspects of signal transduction by cell adhesion receptors. Int. J. Cytology 220: 145-174 (2002)

Alahari S K,: Mapping of the gene for Nischarin, a novel integrin binding protein, to chromosome 3 by fluorescence in situ hybridization). Intl. J. Human Genetics 1: 271-274 (2001)

Alahari S K, Lee, J.L., and Juliano, R.L.: NISCHARIN, a novel protein that interacts with integrin alpha-5 subunit, and inhibits cell migration. J. Cell Biology 151: 1141-1154 (2000)

Methods for study of integrin regulation of receptor tyrosine kinase and G protein coupled receptor signaling to MAP kinases. Methods In Enzymology 333:151-163 (2001)

Shock, D.D., Naik, U.P., Brittain, J.E., Alahari, S K., Sondek, J., and Parise, L.V.: Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton Biochemical Journal 342: 729-735 (1999)

DeLong, R.K., Hoon, Y., Alahari S K, Fisher, M., Short, S.M., Kole, R and Juliano, R. L.: Novel cationic amphiphiles as delivery reagents for antisense oligonucleotides. Nucleic Acids Research 27:3334-3341.(1999)

Hughes, J. A., Astriab,A., Yoo, H., Alahari S K, Liang, E., Sergueev, D., Shaw, B. and Juliano, R.L.: In Vitro Transport and delivery of oligonucleotides. Methods in Enzymology 313:343-359. (1999)

Juliano, R.L., Alahari S K, Yoo, H., Kole, R., and Cho, M. Antisense Pharmacodynamics: Critical issues in the transport & delivery of antisense oligonucleotides. Pharmaceutical Research 16: 494-502.(1999)

Alahari S K, Delong, R., Fisher, M.H., Dean, N. M. Viliet, P and Juliano, R.L. Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression. J.Pharm.Exp. Therapeutics 286:419-428 (1998)

Howe.A., Aplin, A., Alahari S K, and Juliano, R.L.. Integrin signaling and cell growth Control.Current Opinion in Cell Biology 10: 220-231 (1998)

Aplin, A., Howe, A., Alahari, S K, and Juliano, R.L. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, IG-CAMS and selectins. Pharmacological Reviews 50: 197-263 (1998)

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