Multipart chaperone-effector recognition in the type III secretion system of Chlamydia trachomatis. Shen, L., Macnaughtan, M.A., Frohlich, K.M., Cong, Y., Goodwin, O.Y., Chou, C., LeCour Jr, L., Krup, K., Luo, M., & Worthylake, D.K. “” J. Biol. Chem. 290(47) 28141-28155 (2015) [PMID: 26438824]

The Conserved Sequence Repeats of IQGAP1 mediate binding to Ezrin. Jing Liu, Jesse Guidry and David K. Worthylake. Journal of Proteome Reseach. 13(2), 1156-1166. (2014) [PMCID: PMC3975686]

Crystal Structure and Computational Modeling of the Fab Fragment from the Protective anti-Ricin Monoclonal Antibody RAC18.  Zhiyu Zhao, David Worthylake, Louis LeCour, Grace Maresh, and Seth H. Pincus. PLoS One. 2012;7(12) [PMCID:PMC3526572]

Allosteric drug discrimination is coupled to mechanochemical changes in the Kinesin-5 motor core.  Kim, E., Buckley, R., Learman, S., Richard, J., Parke, C., Worthylake, D.K., Wojcik, E.J., Walker, R., and Kim, S.   J. Biol. Chem. 285, 18650-18661. (2010)

The Pre-Hydrolytic State of Eg5 Kinesin Contains Two Water Molecules.  Parke, C. L, Wojcik, E. J., Kim, S., Worthylake, D.K., J. Biol. Chem. 285, 5859-5867. (2010)  (Cited by Faculty of 1000 as a “Must Read” paper; cited by J. Biol. Chem. as “Paper of the Week”) [PMCID:PMC2820811]

Crystal structure of the GTPase-activating protein-related domain from IQGAP1.   Kurella, V.B., Richard, J.M., Parke, C.L., Lecour, L. F., Bellamy Jr., H. D., and Worthylake, D.K.  J. Biol. Chem. 284, 14857-14865. (2009). (Cited by Faculty of 1000 as a “Must Read” paper.) [PMCID:PMC2685667]

Regulation of ROCKII by localization to membrane compartments and binding to Dynamin I.  Tumusiime, S., Rana, M.K., Kher, S.S., Kurella V.B., Williams K.A., Guidry J.J., Worthylake, D.K., and Worthylake R.A.,  Biochem. Biophys. Res. Commun. 381, 393-396 (2009). [PMCID:PMC2671801]

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.  Chhatriwala, M.K., Betts, L. Worthylake, D.K., and Sondek, J.  J Mol. Biol.  368, 1307-1320. (2007). [PMCID:PMC1890047]

Crystal structure of Rac1 bound to its effector phospholipase C-beta2. Jezyk M.R., Snyder J.T., Gershberg, S., Worthylake, D.K., Harden T.K., and Sondek, J.  Nat. Struct. Mol. Biol.  13, 1135-1140. (2006). [PMID:17115053]

Crystal Structure of the DH/PH fragment of Dbs without bound GTPase.  Worthylake, D.K., Rossman, K.L., and Sondek, J. Structure (Camb.) 12, 1078-1086. (2004). [PMID:

Functional analysis of Cdc42 residues required for GEF-catalyzed exchange.  Worthylake, D.K., Rossman, K.L., Snyder J.T., Cheng, L., Whitehead, I.P., and Sondek J.  J. Biol. Chem.  277, 50893-50898 (2002). [PMID:12401782]