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Cardiovascular Center Faculty Published in Angewandte Chemie International

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                The combined research efforts by the Cardiovascular Center faculty contributed to the manuscript, ‘A Novel Esterase-sensitive Prodrug Approach for Controllable Delivery of Persulfide Species’, being accepted in the Angewandte Chemie International 2017 Edition.

Center faculty David J. Lefer, PhD; Chelsea L. Organ, PhD; Rishi K. Trivedi, PhD; and Zhen Li all made contributions to the study. The manuscript was peer-reviewed and accepted on July 12, 2017.

 

The Abstract Summary

“A new strategy to deliver a well-defined persulfide species in a biological medium is described herein. Under near physiological conditions, the persulfide prodrug can be activated by an esterase to generate a "hydroxyl methyl persulfide" intermediate, which rapidly collapses to form a defined persulfide. Such persulfide prodrugs can be used either as chemical tools to study persulfide chemistry and biology or for future development as H2S-based therapeutic reagents. Using the persulfide prodrugs developed in this study, the reactivity between S-methyl methanethiosulfonate (MMTS) with persulfide was unambiguously demonstrated. In addition, a representative prodrug exhibited potent cardioprotective effects in a murine model of myocardial ischemia-reperfusion (MI/R) injury with a bell shape therapeutic profile.”

 

Click to view the full publication

 

Source

Zheng, Y., Yu, B., Li, Z., Yuan, Z., Lefer, D. J., Wang, B., Wang, S., Organ, C. L. and Trivedi, R. K. (), A Novel Esterase-sensitive Prodrug Approach for Controllable Delivery of Persulfide Species. Angew. Chem. Int. Ed.. Accepted Author Manuscript. doi:10.1002/anie.201704117

 

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