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Alison J. Quayle, PhD
Associate Professor, Microbiology, Immunology, and Parasitology
MIP Department
1901 Perdido Street, Box P6-1
New Orleans, LA 70112
Phone: (504) 568-4070
Fax: (504) 568-2918
aquayl@lsuhsc.edu
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| Bio |
Dr. Quayle undertook her graduate training with Dr. Keith James at the University of Edinburgh, and collaborated closely with Dr. Rodney Kelly at the MRC Reproductive Biology Unit. The focus of her PhD was the modulation of cellular immunity by seminal prostaglandins. Her postgraduate studies in reproductive immunology were continued at Brigham and Women’s Hospital, Harvard Medical School, where she worked on mucosal immunity to HIV with Dr. Deborah Anderson. She subsequently became an independent NIH-funded investigator and Assistant Professor at Harvard, continuing to investigate host-pathogen relationships in the genital tract, but focusing on Chlamydia trachomatis. She joined the faculty of LSUHSC as an Associate Professor of Microbiology, Immunology and Parasitology, and she is a principal investigator in the NIH-funded Gulf South Sexually Transmitted Infections/Topical Microbicides Cooperative Research Center. Her research is currently focused on elucidating the effector T cell response to C.trachomatis in the human endocervix, the mechanisms by which C.trachomatis evades T cell immunity, and whether C.trachomatis can become persistent in the human female genital tract.
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| Selected Publications |
Kawana K, Quayle AJ, Ficarra M, Ibana JS, Shen L , Kawana Y, Yang H, Marrero L, Yavagal S, Greene S, Pyles RB, Zhang Y, Blumberg R, Schust DJ. CD1d degradation in Chlamydia trachomatis-infected epithelial cells is a result of both cellular and chlamydial proteasomal activity. J Biol Chem 2007; 282:7368-75.
Quayle AJ, Kourtis AP, Cu-Uvin S, Politch JA, Yang H, Bowman RP, Shah M, Anderson D, Crowley-Nowick P, Duerr A. T lymphocyte profile and total and virus-specific immunoglobulin concentrations in the cervix of Human Immunodeficiency Virus-1-infected women. JAIDS 2007; 44: 292-8.
Pudney J, Quayle AJ, Anderson DJ. Immunological microenvironments in the human vagina and cervix: Mediators of cellular immunity are concentrated in the cervical transformation zone. Biol of Reprod 2005; 73:1253-63
Porter EM, Yang H, Yavagal S, Cuevas-Preza G, Murillo O, Lima H, Greene S, Lewis M, Klein-Patel M, Diamond G, Gulati S, Rice PA, Ganz T and Quayle AJ. Induction and Novel Processing of Human Defensin 5 in the Human Male Urethra during Neisseria gonorrhoeae and Chlamydia trachomatis Infection. Infect Immun 2005; 73: 4823-33.
Quayle AJ, Shah M, CuUvin S, Politch J, Chou C, Anderson DJ,Tuomala R,Crowley-Nowick P, Duerr A., Implications of blood contamination for assessment of local cellular immunity in the endocervix. AIDS Res Human Retroviruses 2004; 20:43-546.
Quayle, AJ, Fidel P, Rosenberg ES. Sex, alloimmunization and susceptibility to HIV. The Lancet 2004; 363; 503-4.
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