Administration Basic Sciences Clinical Sciences Centers of Excellence
 
 

Paulo C. Rodriguez, PhD

Assistant Professor - Research
Microbiology, Immunology & Parasitology
Stanley S. Scott Cancer Center

533 Bolivar Street
Clinical Sciences Research Building
4th Floor, Room 452A
New Orleans, LA  70112
Phone: (504) 568-3350
Lab Phone: (504) 599-0920
Fax: (504) 568-6888

prodri1@lsuhsc.edu
Degrees

Ph.D. - 2008
Louisiana State University Health Sciences Center - New Orleans, LA 

M.S. - 1997
Universidad de Antioquia - Colombia, South America
Bio

Dr. Rodriguez earned his BS in Microbiology and an MS in Immunology from the University of Antioquia in 1995 and 1997, respectively.  He obtained his PhD in the Department of Genetics from Louisiana State University in New Orleans, Louisiana, and completed a research fellowship in the Tumor Immunology/Immunotherapy laboratory at LSU Health Sciences Center.  He is now an Assistant Professor of Microbiology, Immunology, and Parasitology, focusing on amino acid modulation of leukemias.
Research Interests

Modulation of cell signaling in leukemias by amino acid L-Arginine.

Mechanisms of T cell suppression induced by tumors.
Selected Publications

(Past 3 years listed)

Rodriguez PC, Quiceno DG, Ochoa AC. L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood. 2007;109:1568-1573.

Ochoa AC, Zea AH, Hernandez C, Rodriguez PC. Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin Cancer Res. 2007;13. 

Zheng L, Asprodites N, Keene AH, Rodriguez P, Brown KD, Davila E. TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements. Blood. 2008;111:2704-2713. 

Rodriguez PC, Hernandez CP, Ochoa AC. L-arginme availability regulates cyclin D3 mrna stability in human T cells by controlling hur expression. Journal of Immunotherapy. 2008;31:966-967. 

Rodríguez PC, Ochoa AC. Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives. Immunol Rev. 2008;222:180-191. 

Rodriguez PC, Ernstoff MS, Hernandez C, et al. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res. 2009;69:1553-1560.

Norian LA, Rodriguez PC, O'mara LA, et al.  Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism.  Cancer Res. 2009;69:3086-3094
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