
| Administration | Basic Sciences | Clinical Sciences | Centers of Excellence |
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| Degrees |
BS Zoology - 1977 PhD Immunology - 1985 |
| Research Interests |
The Sturtevant lab focuses on the intracellular events that occur after the opportunistic fungus, Candida albicans, interacts with new environments. The ability of C. albicans to switch between growth forms is important for initiation and maintenance of infection. The laboratory is using a combination of molecular genetics, microbiological, and immunochemical methods in conjuction with cellular studies to determine the roles of specified genes. The major project focuses on the C. albicans 14-3-3 gene, a multifunctional signal involved in a wide variety of cellular processes in other eukaryotes. |
| Teaching Activities |
Molecular Biology of Pathogenic Eukaryotes |
| Selected Publications |
Kelly, M.N., Johnston, D.A., Peel, B.A., Morgan, T.W., Palmer, G.E., and J.E. Sturtevant. Bmh1p (14-3-3) mediates pathways associated with virulence in Candida albicans. Microbiology, 155: 1536-46.2009. Sturtevant, J. Reporter Gene Assays. InCandida albicans Methods and Protocols, Springer Protocols: Methods in Molecular Medicine, R.A. Calderone & R.L. Cihlar, eds. P 157-168. 2009. Palmer, GE, Kelly, MN, and Sturtevant, JE. Autophagy in the pathogen Candida albicans. Microbiology, 153: 51-58. 2007 Palmer, G.E., Kelly, M. N., and J.E. Sturtevant., The Candida albicans vacuole is required for differentiation and efficient macrophage killing, Eukaryotic Cell, 4: 1677 - 1686, 2005. Palmer, G.E. and Sturtevant, J., Random mutagenesis of an essential C.albicans gene., Genetics 46: 343-356, 2004. Palmer, G.E, Johnson, K.J., Ghosh, S and Sturtevant, J., Mutant alleles of the essential 14-3-3 gene in Candida albicans distinguish between growth and filamentation, Microbiology, 150: 1911-1924, 2004. Sturtevant, J and Cihlar RL, Strategies for the study of gene expression in fungi. In The Mycota XII Human Fungal Pathogens. JE Domer and GS Kobayashi (eds). Springer Verlag 2004 Sturtevant J,, Translation elongation-3-like factors: Are they rational antifungal targets?, Expert Opin Ther Targets 6:545-553, 2002.
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