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Nicolas G. Bazan , M.D., Ph.D., Director
Ernest C. and Yvette C. Villere Professor of Ophthalmology, Biochemistry and Molecular Biology, and Neurology |
| Degrees |
1965: MD - Medical School, U. Tucuman, Argentina 1966-1968: Research Thesis Work - Harvard Medical School 1971: PhD - Medical School, U. Tucuman, Argentina |
| Bio |
Awards/Recognitions/Lectures 1991: Citation Classic, “Neural Stimulation or Onset of Cerebral Ischemia Activates Phospholipase A2” Current Contents/Life Sciences |
| Clinical Interests |
Current Research A major goal of the N. Bazan laboratory is to understand the principles underlying endogenous responses of the retina and brain to injury and neurodegeneration. For this purpose, a convergence of approaches, including cellular, neurochemical and molecular, are used, complemented by cell cultures (e.g. hippocampal neurons) and experimental models of neurological (epilepsy, stroke, Alzheimer’s disease) and retinal diseases (age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy). We are investigating the pro-inflammatory mediator, platelet-activating factor (PAF). This mediator also is produced at the synapse and is physiologic as well. However when it accumulates, it triggers cell injury. Our laboratory has developed specific PAF antagonists and is using these tools to explore further its significance. We are also exploring a gene, the inducible prostaglandin synthase (COX-2). We have found that PAF induces this gene. The product of COX-2 accumulates in hippocampus in models of epilepsy, as well as in retina in light-induced photoreceptor degeneration. The lab is also studying membrane biogenesis, in terms of the supply and trafficking of docosahexaenoic acid, a key building block in synapses and photoreceptors. In our studies of excitable membrane biogenesis, we have discovered that the essential fatty acid, docosahexaenoic acid, which is a major component of photoreceptors, is conserved by means of metabolic loops involving the liver and the interstitial space surrounding photoreceptors. These loops are altered in certain retinal degenerations and, possibly, also in some neurological diseases. The central hypothesis being explored is that lipid messengers mediate critical responses for cell survival. Phospholipases A2-generated messengers modulate both synaptic receptors, as well as downstream signaling through endogenous lipid neuroprotective messengers (e.g. docosanoids). Sites of pharmacological action, as well as novel drugs acting on these informational pathways, are being identified. The essential docosahexaenoic acid, in addition, is the precursor of neuroprotectin D1 (NPD1). This new lipid mediator is anti-inflammatory, a potent upregulator of Bcl-2 anti-apoptotic and a downregulator of Bcl-2 pro-apoptotic proteins. Our goal is to determine the crosstalk between synapses and genes, and between neurons and astrocytes, that modulate long-term responses, which could perhaps be pharmacologically manipulated to prevent or repair injury, inflammation and cellular damage occurring in diseases. |
| Research Interests |
Keywords: |
| Teaching Activities |
1968-1970: Assistant Professor of Biochemistry, University of Toronto, Canada, and Assistant Director, Neurochemistry, Clarke Institute of Psychology 1970-1981: Professor of Biological Chemistry and Director, Institute of Biochemistry. Investigator, U. Nac. del Sur CONICET, Argentina |
| Selected Publications |
Key Recent Papers: Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D., Bazan, N.G: Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc. Natl. Acad. Sci. USA. 104 (2007) 13152-13157. Mukherjee, P.K., Marcheselli, V.L., de Rivero Vaccari, J.C., Gordon, W.C., Jackson, F.E., Bazan, N.G: Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc. Natl. Acad. Sci. USA. 104 (2007) 13158-13163. Bazan, NG: Homeostatic regulation of photoreceptor cell integrity: Significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid. The Proctor Lecture. Invest Ophthalmol Vis Sci. 48 (2007) 4866-4881. Bazan, NG: Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci. 29 (2006) 263-271. Lukiw, W.J., Cui, J.G., Marcheselli, V.L., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., Bazan, N.G: A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest. 115 (2005) 2774-2783. Belayev, L., Marcheselli, V.L., Khoutorova, L., Rodriguez de Turco, E.B., Busto, R., Ginsberg, M.D., Bazan, N.G: Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke 36 (2005) 118-123. Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G: Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA. 101 (2004) 8491-8496. Bazan, N.G: Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Am J Clin Nutr. (in press), 2008. Bazan, N.G: Cell signaling by polyunsaturated fatty acids in epileptogenesis., Encyclopedia of Basic Epilepsy Research. (in press), 2008. Bazan, N.G., Musto, A.E: Inositol lipid signaling in synaptic activity, neuronal plasticity and epileptogenesis., Encyclopedia of Basic Epilepsy Research. (in press). 2008. Van Meter, K., Sheps, S., Kriedt, F., Moises, J., Barratt, D., Murphy-Lavoie, H., Harch, P.G., Bazan, N.G: Hyperbaric oxygen improves rate of return of spontaneous circulation after prolonged normothermic porcine cardiopulmonary arrest. Resuscitation 78:200-214, 2008. Bazan, N.G: Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv Exp Med Biol. 613:39-44, 2008. Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D., Bazan, N.G: Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci USA. 104:13152-13157, 2007. Mukherjee, P.K., Marcheselli, V.L., de Rivero Vaccari, J.C., Gordon, W.C., Jackson. F.E., Bazan, N.G: Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc Natl Acad Sci USA. 104:13158-13163, 2007. Mukherjee, P.K., Chawla, A., Loayza, M.S., Bazan, N.G: Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Prostaglandins Leukot Essent Fatty Acids. 77:233-238, 2007. Bazan, N.G: Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. Invest Ophthalmol Vis Sci. 48:4866-4881, 2007. Ryan, S.D., Harris, C.S., Mo, F., Lee, H., Hou, S.T., Bazan, N.G: Haddad PS, Arnason JT, Bennett SA., Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem 103:88-97, 2007. Esquenazi, S., He, J., Li, N., Bazan, N.G., Esquenazi, I., Bazan, H.E: Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stromal cells in mice with and without dry eye after photorefractive keratectomy. Clin Experiment Ophthalmol. 35:545-549, 2007. Kolko, M., Prause, J.U., Bazan, N.G., Heegaard, S: Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases, Acta Ophthalmol Scand. 85:317-323, 2007. Cui, J.G., Zhang, X., Zhao, Y.H., Chen, C., Bazan, N.G: Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. Biochem Biophys Res Commun 350:358-363, 2006. Erratum in: Biochem Biophys Res Commun. 359:187-188, 2007. Vaccarino, A.L., Paul, D., Mukherjee, P.K., Rodríguez de Turco, E.B., Marcheselli, V.L., Xu, L., Trudell, M.L., Minguez, J.M., Matía, M.P., Sunkel, C., Alvarez-Builla, J., Bazan, N.G: Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs. Bioorg Med Chem. 15:2206-2215, 2007. Kolko, M., Wang, J., Zhan, C., Poulsen, K.A., Prause, J.U., Nissen, M.H., Heegaard, S., Bazan, N.G: Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci. 48:1401-1409, 2007. Bazan, N.G: Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care. 10:136-141, 2007. Bazan, N.G: Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv Exp Med Biol. 572:531-540, 2006. Lukiw, W.J., Bazan, N.G: Survival signalling in Alzheimer's disease. Biochem Soc Trans. 34:1277-1282, 2006. Cole-Edwards, K.K., Musto, A.E., Bazan, N.G: c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes. J Neurosci 26:8295-8304, 2006. Bazan, N.G: The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol. 26:901-913, 2006. Bazan, N.G: Cell survival matters:docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci. (Review, May Issue), 2006. Lukiw, W.J., Mukherjee, P.K., Cui, J.G., Bazan, N.G:, A2E selectively induces COX-2 in ARPE-19 and human neural cells. Curr Eye Res. 31:259-263, 2006. Kolko, M., Christoffersen, N.R., Barreiro, S.G., Miller, M.L., Pizza, A.J., Bazan, N.G: Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. J Neurosci Res. 83:874-882, 2006. Musto, A., Bazan, N.G: Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. Epilepsia. 47:267-276, 2006. He J, Bazan NG, Bazan HE: Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. 124:70-78, 2006. Faghiri, Z., Bazan, N.G: Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 47:397-404, 2006. Esquenazi, S., He, J., Kim, D.B., Bazan, N.G., Bui, V., Bazan, H.E., Wound-healing response and refractive regression after conductive keratoplasty. J Cataract Refract Surg. 32:480-486, 2006. Chen, C., Hardy, M., Zhang, J., LaHoste, G.J., Bazan, N.G: Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments., Biochem Biophys Res Commun. 10;340:435-440, 2006. McDermott, C.M., Hardy, M.N., Bazan, N.G., Magee, J.C: Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J Physiol. 1;570:553-65, 2006. Malcher-Lopes, R., Di, S., Marcheselli, V.S., Weng, F.J., Stuart, C.T., Bazan, N.G: Tasker JG., Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci. 26:6643-6650, 2006. Eaquenazi, S., He, J., Bazan, H.E., Bazan, N.G: Use of autologous serum in corneal epithelial defects post-lamellar surgery. Cornea. 24:992-997, 2005. Cole-Edwards, K.K., Bazan, N.G: Lipid signaling in experimental epilepsy. Neurochem Res. 847-853 (Review), 2005. Tian, X., Bazan, N.G: Neuroprotection by platelet-activating factor antagonism. Ann N Y Acad Sci. 1053:455-456 (Review), 2005. Kolko, M., Christoffersen, N.R., Varoqui, H., Bazan, N.G:, Expression and induction of secretory phospholipase A2 group IB in brain. Cell Mol Neurobiol. 25:1107-1122, 2005. Lukiw, W.J., Pappolla, M., Pelaez, R.P., Bazan, N.G: Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism. Cell Mol Neurobiol 25:475-483 (Review), 2005. Chen, C., Bazan, N.G: Endogenous PGE 2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol 93:929-941, 2005. Mattson, M.P., Bazan, N.G: Apoptosis and necrosis., Basic Neurochemistry 7 th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2005. Zhu, P., Genc, A., Zhang, X., Zhang, J., Bazan, N.G, Chen, C: Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors. J Neurosci Res 15;81:817-826, 2005. Bazan, N.G: Synaptic signaling by lipids in the life and death of neurons. Mol Neurobiol 31:219-230 (Review), 2005. Bazan, N.G:, Neuroprotectin D1 (NPD1): A DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol 15:159-166 (Review), 2005. Bazan, N.G., Marcheselli, V.L., Cole-Edwards, K: Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci .1053:137-147 (Review), 2005. Chen, C., Bazan, N.G: Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid. Mediat. 77:65-76 (Review), 2005. Bazan, N.G: Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol. 32:89-103 (Review), 2005. Sang, N., Zhang, J., Marcheselli, V.L., Bazan, N.G., Chen, C: Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. J Neurosci. 26;25:9858-9870, 2005. Di, S., Boudaba, C., Popescu, I.R., Weng, F.J., Harris, C., Marcheselli, V.L., Bazan, N.G., Tasker, J.G: Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol. 5;569:751-760, 2005. Lukiw, W.J., Cui, J.G., Musto, A.E., Musto, B.C., Bazan, N.G: Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun. 9;338:77-81, 2005. Esquenazi, S., He, J., Bazan, N.G., Bazan, H.E: Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 31:1632-1639, 2005. Esquenazi, S., Bazan, H.E., Bui, V., He, J., Kim, D.B., Bazan, N.G: Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. Invest Ophthalmol Vis Sci. 46:3121-3127, 2005. Di, S., Malcher-Lopes, R., Marcheselli, V.L., Bazan, N.G., Chen, C: Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology. 146:4292-4301, 2005. Ruskin, D.N., Dunn, K.E., Billiot, I., Bazan, N.G., Lahoste, G.J: Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze. Life Sci. 30, [Epub ahead of print], 2005. Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G: Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res 81:742-750, 2005. Teather, L.A., Packard, M.G., Smith, D.E., Ellis-Behnke, R.G., Bazan, N.G: Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks. Neurobiol Learn Mem 84:75-84, 2005. Boedker, M., Boetkjaer, A., Bazan, N.G., Cui, J.G., Zhao, Y., Pelaez, R.P., Lukiw, W.J: Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. Neurosci Lett 20-27;380:176-180, 2005. Sharma, G.D., Ottino, P., Bazan, N.G., Bazan, H.E: Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J Biol Chem 4;280:7917-7924, 2005. Lukiw, W.,Cui, J.G., Marcheselli, V., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., Bazan, N.G: A role for docosahexaenoic acid-derived neuroprotection D1 in neural cell survival and Alzheimer’s disease. J Clin Inv. 115:2774-2783, 2005. Belayev, L., Marcheselli, V.L., Khoutorova, L., Rodriguez de Turco, E.B., Busto, R., Ginsberg, M.D., Bazan, N.G: Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke 36:118-123, 2005. Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G: Neuroprotectin D1: A docosahexanoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci, USA 101:8491-8496, 2004. Ottino, P., Finley, J., Rojo, E., Ottlecz, A., Lambrou, G.N., Bazan, H.E., Bazan, N.G: Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells. Involvement of cytosolic phospholipase A(2) activity. Mol Vis 10:341-350, 2004. Zhu, P., DeCoster, M.A., Bazan, N.G: Interplay among platelet-activating factor, oxidative stress, and group I metabotropic, glutamate receptors modulates neuronal survival. J Neurosci Res 77:525-531, 2004. Cui, J.G., Kuroda, H., Chandrasekharan, N.V., Pelaez, R.P., Simmons, D.L., Bazan, N.G., Lukiw, W.J: Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem Res 29:1731-1737, 2004. Rollin, S., Lemieux, C., Maliba, R., Favier, J., Villeneuve, L.R., Allen, B.G., Soker, S., Bazan, N.G., Merhi, Y., Sirois, M.G: VEGF-mediated endothelial P-selectin translocation: Role of VEGF receptors and endogenous PAF synthesis. Blood 103:3789-3797, 2004. Axelrad, T.W., Deo, D.D., Ottino, P., Van Kirki, J., Bazan, N.G., Bazan, H,E.P., Hun,t J.D: Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. FASEB J 18:568-570, 2004. Deo, D.D., Bazan, N.G., Hunt, J.D: Activation of platelet-activating factor (PAF) receptor-coupled Ga q leads to stimulation of Src and focal adhesion kinase (FAK) via two separate pathways in human umbilical vein endothelial cells (HUVEC). J Biol Chem 279:3497-3508, 2004. Ma, X., Ottino, P., Bazan, H.E., Bazan, N.G: Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. Invest Ophthalmol Vis Sci. 45:2915-2921, 2004. Kolko, M., Christoffersen, N.R., Barreiro, S.G., Bazan, N.G: Expression and location of mRNAs encoding multiple forms of secretory phospholipase A 2 in the rat retina. J Neurosci Res 77:517-524, 2004. Katsura, K., Rodriguez de Turco, E.B., Siesjö, B.K., Bazan, N.G: Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. Brain Res 1030:133-140, 2004. Tu, B., Bazan, N.G: Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenases-2 expression in neocortex. Exp. Neurol. 179:167-175, 2003. Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G: DNA repair in photoreceptor survival. Mol Neurobiol 28:111-122 (Review), 2003. McDermott, C., LaHoste, G.J., Chen, C., Musto, A., Bazan, N.G., Magee, J.C: Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci 23:9687-9695, 2003. Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronert, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G: Novel docosanoids inhibit brain ischema-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 278:43807-43817, 2003. Bazan, N.G: Synaptic lipid signaling: Significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res 44:2221-2233, 2003. Lukiw, W.J., Ottlecz, A., Lambrou, G., Grueninger, M., Finley, J., Thompson, H.W., Bazan, N.G: Coordinate activation of HIF-1 and NF-KappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investi Ophthalmol and Vis Sci 44:4163-4170, 2003. Chen, C., Bazan, N.G: Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT 2 receptor. NeuroReport 14:743-747, 2003. Kolko, M., Rodriguez de Turco, E.B., Diemer, N.H., Bazan, N.G: Neuronal damage by secretory phospholipase A2: Modulation of cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. Neurosci Lett 338:164-168, 2003. Bazan, N.G. and Flower, R.J: Lipid signals in pain control. Nature 420:135-138, (News and Views), 2002. Bazan, N.G. and Lukiw, W.J: Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1 beta and amyloid-beta 42 peptide is potentiated by hypoxia in primary human neural cells. J Biol Chem 277:30359-30367, 2002. Gordon, W.C., Casey, D.M., Lukiw, W.J., Bazan, N.G: DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci 43:3511-3521, 2002. Rodriguez de Turco, E.B., Belayev, L., Liu, Y., Busto, R., Parkins, N., Bazan, N.G., Ginsberg, M.D: Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin. J Neurochem 82:1-10, 2002. DeCoster, M.A., Lambeau, G., Lazdunski, M., Bazan, N.G: Secreted phospholipase A 2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J Neurosci Res 67:634-645, 2002. Rodriguez de Turco, E.B., Jackson, F.R., DeCoster, M.A., Kolko, M., Bazan, N.G: Glutatmate signaling and secretory phospholipase A 2 modulate the release of arachidonic acid from neuronal membrane. J Neurosi Res 68:558-567, 2002. Teather, L.A., Packard, M.A., Bazan, N.G: Post-training cyclooxygenase-2 (COX) inhibition impairs memory consolidation. Learning and Memory 9:41-47, 2002. Deo, D.D., Axelrad, T.W., Robert, E.G., Marcheselli, V.L., Bazan, N.G, Hunt JD: Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells: Evidence for a dual kinase mechanism. J Biol Chem 277:21237-21245, 2002. Parker, M.A., Bazan, H.E.P., Marcheselli, V.L., Rodriguez de Turco, E.B., Bazan, N.G: Platelet-activating factor induces permeability transition and cytochorme c release in isolated brain mitochondria. J Neurosci Res 68:39-50, 2002. Chen, C., Magee, J.C., Bazan, N.G: Cyclooxygenase-2 regulates prostaglandin E 2 signaling in hippocampal long- term synaptic plasticity. J Neurophysiol 87:2851-2857, 2002. Kolko, M., Nielsen, M., Bazan, N.G., Diemer, N: Secretory phospholipase A 2 induces delayed neuronal COX-2 expression as compared to glutamate. J Neurosci Res 69:169-177, 2002. Bazan, N.G., Tu, B., Rodriguez de Turco, E.B: What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. Prog Brain Res 135:175-185, (Review), 2002. Rodriguez de Turco, E.B., Tan, W., Tophan, M.K., Sakane, F., Marcheselli, V.L., Chen, C., Taketomi, A., Prescott, S., Bazan, N.G: Diacylglycerol kinase epsilon regulates seizures susceptibility and long term potentiation through inositol lipid signaling. Proc Natl Acad Sci 98:4740-4745, 2001. Bazan, N.G: COX-2 as a multifunctional neuronal modulator. Nature Medicine 7:414-415, (News and Views), 2001. Chen, C., Magee, J.C., Marcheselli, V.L., Hardy, M., Bazan, N.G: Attenuated long-term potentiation in hippocampal dentate gyrus neurons of mice deficient in the platelet-activating factor receptor. J Neurophysiol 85:384-390, 2001. Lukiw, W.J., Carver, L.A., LeBlanc, H.J., Bazan, N.G: Analysis of 1184 gene transcript levels in Alzheimer CA1 hippocampus: synaptic signaling and transcription factor deficits and upregulation of pro-inflammatory pathways. Alzheimer’s Reports 3:143-149, 2000. Lukiw, W.J., Rogaev, E.I., Bazan, N.G: Potential of transcriptional coordination of nine genes associated with Alzheimer’s disease. Alzheimer’s Reports 3:231-242, 2000. Ershov, A.V., Bazan, N.G: Photoreceptor phagocytosis selectively activates PPARa expression in retinal pigment epithelial cells. J Neurosci Res 60:328-337, 2000. |
| Additional Info |
Funding: “Neuroprotectin D1 slows photoreceptor degeneration” “RPE Messengers, Transcription and Photoreceptor Renewal” “Neuroprotection: Lipid Signaling in Ischemia-Reperfusion” “Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience” “A Mouse Model for Usher Syndrome Type 1C” |
