Nicolas G. Bazan, M.D., Ph.D.
Ernest C. and Yvette C. Villere Chair
for the Study of Retinal Degeneration
Professor of Ophthalmology, Biochemistry and
Molecular Biology, and Neurology
Director, Neuroscience Center of Excellence
2020 Gravier Street, Suite D
New Orleans, LA 70112
Phone: (504) 599-0831/32
Fax: (504) 568-5801
Contributions to Science
Nicolas G. Bazan Laboratory Page
Dr. Bazan featured speaker at MUSC Aging Research Day
Nicolas Bazan Keynote Lecture
Save the Date: 2015 McGinty Conference
Nov. 3, 2015, Oregon Convention Center
Conference Chair: LIPID MEDIATORS IN HEALTH AND DISEASE II: From The Cutting Edge and 7TH INTERNATIONAL CONFERENCE on PHOSPHOLIPASE A2 and LIPID MEDIATORS: From Bench To Translational Medicine
La Jolla, California, May 19-20, 2016
Nicolas Bazan invited speaker
Lipidomics Gateway, May 12-13, 2015,
La Jolla, CA
Dr. Bazan featured on Research to Prevent Blindness Facebook page
New Orleans Biodistrict Newsletter
; featuring Dr. Nicolas G. Bazan on page 3
Links to Interviews:
Focus on neuroscience could lead to treatments, economic development for New Orleans: Nicolas Bazan
Could Charity Hospital become a world brain health center ...
Dr. Nicolas G. Bazan interviewed on the repurpose of Charity Hospital in New Orleans as an integrated brain research and treatment center
What is new with the brain and docosanoids? - Prof. Nicolas Bazan
Hippocampal Neuro-Networks and Dendritic Spine Perturbations in Epileptogenesis
Are Attenuated by Neuroprotectin D1
LSU Health New Orleans: Novel compound switches off epilepsy development
LSU Health New Orleans research finds novel compound switches off epilepsy development
Top Addiction Specialist Raises Awareness
Link to article
Dr. Hamilton Farris, Mette Flatt, Dr. William Gordon, Dr. Jennifer Lentz,
and Dr. Nicolas Bazan (the research team)
Local medical research team makes breakthrough in curing deafness
link to page Meg Farris, WWWLTV.com, February, 4 2013.
Balanced Body and Brain: A FOX 8 special report
Link to interview
Researchers in Town to Share Discoveries on Brain Injuries SFN Convention 2012
Link to interview with Dr. Bazan and other Neuroscientists WWL-TV
Study: Smoking during pregnancy could lead to child's weight, drug issues
The Arts of Neuroscientists: Nicolas Bazan - Dana Foundation
The Dana Alliance for Brain Initiatives, a nonprofit organization of more than 300 leading neuroscientists, works to advance public awareness about the progress ...www.dana.org/news/features/detail.aspx?id=39684
New Study Backs Up Benefits of Fish Oil Supplements Meg Farris/WWL-TV 091212
DHA: A Sentinel for Neuroprotection and Brain Repair
Global Organization for EPA and DHA (GOED) Exchange June 8, 2012
Early History of Omega-3 Research, Boston, Massachusetts
Protect your vision by altering your diet:
Molly Kimball, The Times Picayune, 031612
Dr. Isabel Univision National Radio Show – 2/29/12-
Listen by clicking here: http://www.miunicast.com/Public/Media/DraIsabel-2012.02.29.mp3
Turn On Your Inner Light Radio Show – 2/21/12- Listen by clicking here:
Steve Gleason's plight focuses attention on ALS
A new discovery could reverse the effects of a stroke
Stopping Stroke Damage with a Shot
Ground breaks on new teaching hospital
Medical watch: for some could tanning be an addiction?
New discovery from a local doctor that may help people suffering from a stroke
Omega 3 fatty acids may help prevent Alzheimer's
Impact of brain disease on families
Audio Interview with Dr. Nicolas Bazan
1965: M.D. - Medical School, U. Tucuman, Argentina
1966-1968: Research Thesis Work - Harvard Medical School (1970: Ph.D. - Medical School, U. Tucuman, Argentina)
1968-1970: Assistant Professor of Biochemistry, University of Toronto, Canada, and Assistant Director, Neurochemistry, Clarke Institute of Psychology
1970-1981: Professor of Biological Chemistry and Director, Institute of Biochemistry. Investigator, U. Nac. del Sur CONICET, Argentina
1981: Professor of Ophthalmology, Biochemistry, Molecular Biology, and Neurology, LSU Health Sciences Center, School of Medicine, New Orleans
1988-present: Director, LSU Neuroscience Center of Excellence, New Orleans
- Member, National Institute of Health, Biology and Disease of the Posterior Eye Study Section, Center for Scientific Review, Bethesda, MD, July 1, 2010 - June 30, 2014
- Reviewer, National Institutes of Health, National Institute of General Medical Sciences, Bethesda, MD, 2007
- Reviewer, National Institutes of Health, Special Emphasis Panel/Scientific Review Group 2007-05, ZRG1, MDCN-B, Mitochondrial and Cerebral Ischemia, Center for Scientific Review, Bethesda, MD, 2007
- Reviewer, US Amy Medical Research and Material Command (USAMRMC), American Institute of Biological Sciences, Scientific Peer Advisory and Review Services, Reston, VA, 2007
- Reviewer, Alzheimer’s Association Grant Reviews, Chicago, IL, 2007, 2010
- Reviewer, Molecular and Integrative Signal Transduction (MIST) Study Section, Bethesda, MD, 2007
- Reviewer, National Center for Research Resources, Institutional Clinical Translational Science Award (CTSA) Center Special Emphasis Review Panel, 2008
- Reviewer, National Institute of Health, Biophysical and Physiological Neuroscience ZRG1 F03B (2), Washington, DC, 2009
- Reviewer, National Institute of Health, Center for Scientific Review, Special Emphasis Panel, Challenge Grant ZRG1 CBN 58, 2009
- National Institute of Health, S10 Shared Instrumentation and Microscopy Review, Center for Scientific Review, Chicago, IL, November 12-13, 2009
- National Institute of Health, Center for Scientific Review, Brain Disorders and Clinical Neuroscience Integrated Review Group, Clinical Neuroplasticity and Neurotransmitters Study Section (CNNT), San Francisco, CA, February 11-12, 2010
Awarded International Gradle Medal
Healthcare Journal of New Orleans
Bazan Awarded International Gradle Medal. Dr Nicolas Bazan Nicolas G. Bazan, MD, PhD,
Professor and Director of the Neuroscience Center of Excellence at LSU Health
LSU professor gets medal for teaching
Bazan awarded Gradle Medal/Baton Rouge Advocate, February 21, 2016
Dr. Nicolas G. Bazan, professor and director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine,
has been presented the 2016 Gradle Medal for Teaching by the Pan-American Association of Ophthalmology.
Baton Rouge Advocate, February 21, 2016
ANA Onsite Program Addendum October 15, 2013
The Art of Science
The Constellation of Events at the Onset of Dementia: An Artistic Perspective
Una Vida: A Fable of Music and the Mind
The Medal Professor Miroslaw M. Mossakowski Award to Nicolas G. Bazan, M.D., Ph.D.
October 2013 in Warsaw, Poland
Dr. Nicolas Bazan honored at ISN and ASN conference in Cancun, Mexico held April 17-19, 2013
- Research to Prevent Blindness, Incorporated, NY
- International Research Scholar, Research to Prevent Blindness, Incorporated, NY, 1977
- William & Mary Greve International Scholar, 1983-84
- Elected to Council ISN, 1979‑83
- Elected to Council ASN, 1988‑90
- Gold Medal, Fondazione Giovanni Lorenzini, Milan, Italy, 1981
- Honorary Professor, Universidad de Tucuman, Argentina, 1987‑
- Javits Neuroscience Award NINDS, 1989‑1996
- Citation Classic, Current Content/ Life Sciences 30:10(July 29), 1991
- Elected Member, Academy of Medical Sciences, Cordoba, Argentina, 1991-
- Merck Lecture in Pharmacology, McGill University, Canada, 1992
- Elected Member, Royal Academy of Sciences, Spain, 1993, 1996
- 11th William Harvey Lecture, London, 1994
- Role Model Awardee, Young Leadership Council of New Orleans, 1994
- Caputto Gold Medal, Argentine Neurochemical Society, 1994
- Boyd Professor, Louisiana State University Medical Center, 1994
- Welcome Professorship and Lecture (Burroughs Welcome Fund/FASEB) at University of North Carolina, 1996
- Merit Award, Distinguished Argentine Abroad, National Research Council of Argentina, Presented by the President of Argentina, 1996
- Annual John Dorsey Lecture, Wayne State University, Detroit, Michigan, 1996
- Guest of Honor, Inaugural Symposium, Frontiers in Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden, 1996
- William H. Bell Lectureship, Oklahoma Medical Research Foundation, Oklahoma City, OK, 1997
- Robert Schwab Lecturer, 13th Ann. American Academy of Clinical Neurophysiology, 1998
- Mayerson-Di Luzio Lecture, Tulane University School of Medicine, Dept. Physiology, 1998
- Loris & David Rich Lecture in Visual Science, University of Alabama, Birmingham, AL, 1999
- President, American Society for Neurochemistry, 1999-2001
- Elected Fellow, Medical Society of Ireland, The Royal College of Physicians of Ireland, Dublin, 1999-
- Doctor Honoris Causa, Universidad de Nacional de Tucuman, Argentina, 1999
- Endre A. Balazs Prize, International Society of Eye Research, 2000
- Citybusiness 2002 Innovator of the Year Award New Orleans, LA, 2002
- The Alzheimer’s Association Greater New Orleans Chapter Award, NOLA, 2002
- Career Service Awards, 20 years, LSUHSC, NOLA, 2003
- Family Services of Greater New Orleans (Ten Outstanding Persons) Award, 2003
- First Leon S. Wolfe Lecture, Montreal Neurological Institute, Montreal, Canada, 2003
- Association for Research in Vision and Ophthalmology, Proctor Medal and Lecture (highest honor of this Association), 2007
- Association for Research in Vision and Ophthalmology Fellow, 2009
- Chevreul Medal, Paris, France, 2011
- Translational Research Initiative in Ophthalmology (TRIO) 2012 Program PDF
- 2nd Annual Gladstone/DZNE Workshop 2012 Program PDF
- GOED Exchange 2012 Program PDF
Editorial Boards (selected)
- Journal of Neurochemistry, 1981‑1989
- Journal of Lipid Mediators, 1988‑1993
- Journal of Cerebral Blood Flow and Metabolism, 1988‑1996
- Molecular Neurobiology (Editor-in-Chief and Founder), 1987‑
- Journal of Molecular Neuroscience, 1989‑1990
- Journal of Nutritional Biochemistry, 1990‑2001
- Journal of Clinical Neuroscience, 1993-1999
- Receptors and Signal Transduction, 1996-1998
- Journal of Biological Chemistry, 1997-2002
- Proc Soc Exp Biol & Med, 2000-2004
- Current Neurovascular Research, 2004-
- Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition, At Large Editor, 2005-
- Cell Death & Differentiation (Nature journal), 2007-
- Journal of Neurodegeneration and Regeneration, 2008-
- Cell Death & Disease (Nature journal), 2010-
Barry James Marshall, MD, Nobel Laureate in Physiology or Medicine, 2005
and Nicolas G. Bazan at the ARVO 2014 meeting in Orlando, Florida.
A major goal of the N. Bazan laboratory is to understand the principles underlying endogenous responses of the central nervous system to injury and neurodegeneration. For this purpose, a convergence of approaches, including cellular and molecular, are used, complemented by cell cultures (e.g. hippocampal neurons) and experimental models of neurological (epilepsy, stroke, Alzheimer’s disease) and retinal diseases (age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy). His laboratory is interested in the significance of the selective enrichment in omega-3 essential fatty acids (docosahexaenoyl–DHA–chains of membrane phospholipids, 22C and 6 double bonds) in the nervous system (e.g. photoreceptors, synaptic membranes).
While studying mechanisms of cell survival in neurodegenerations, he and his colleagues discovered a docosanoid synthesized from DHA by a 15-lipoxygenase, which was named neuroprotectin D1 – (NPD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,-13E,15E,19Z hexaenoic acid).
This mediator is a docosanoid because it is derived from a 22C precursor (DHA), unlike eicosanoids, which are derived from the 20C arachidonic acid family member of essential fatty acids not enriched in the nervous system. NPD1 is promptly made in response to oxidative stress and brain ischemia-reperfusion, and in the presence of neurotrophins. NPD1 is neuroprotective in experimental stroke, oxidative-stressed retinal pigment epithelial (RPE) cells, and in human brain cells exposed to amyloid-β peptide. Thus NPD1 is a protective sentinel, one of the very first defenses activated when cell homeostasis is threatened by neurodegenerations.
Recent studies highlight the specificity and potency of NPD1 spanning beneficial bioactivity during initiation and early progression of neurodegenerations: 1) Photoreceptors renew membrane disks containing the phototransduction apparatus and DHA intermittently via shedding of their tips and phagocytosis by retinal pigment epithelial (RPE) cells. At the same time, new membrane disks are made at the base of the outer segments; their length remains constant and cell integrity is maintained remarkably unchanged throughout many decades. This outcome occurs in spite of the fact that the photoreceptors are in an oxidative stress-prone environment (light, high O2 consumption, high polyunsaturated fatty acid fluxes, etc).
He and his colleagues show that phagocytosis of photoreceptor disks promotes via NPD1 synthesis specific refractoriness to oxidative stress-induced apoptosis in RPE cells, which in turn fosters homeostatic photoreceptor cell integrity. Disruptions of the sentinel role of NPD1 in photoreceptor renewal may participate in macular degeneration and other retinal degenerations leading to blindness.
2) In brain ischemia-reperfusion (experimental stroke), DHA is released and used for NPD1 synthesis, which in turn elicits neuroprotection. Anti-apoptotic BCL-2 family of proteins availability is positively modulated by NPD1, whereas pro-apoptotic BCL-2 proteins are negatively regulated, as is the arrival of leukocytes due
to neurovascular unit breakdown.
3) They also found that NPD1 is drastically reduced in CA1 areas from Alzheimer’s patients. Thus they have explored the significance of NPD1 in cellular models that recapitulate part of the Alzheimer’s pathology. Human neurons and astrocytes challenged by amyloid-β or by overexpressing APPsw (double Swedish mutation) show that NPD1 downregulates amyloidogenic processing of amyloid-β precursor protein, switches off pro-inflammatory gene expression (TNF-α, COX-2 and B-94-TNF-α inducible pro-inflammatory element), and promotes neural cell survival. The apoptotic cascade involves multiple checkpoints. NPD1 regulation targets upstream events of apoptosis as well as neuroinflammatory signaling, in turn promoting homeostatic regulation of cell integrity.
We are investigating the pro-inflammatory mediator, platelet-activating factor (PAF). This mediator also is produced at the synapse and is physiologic as well. However when it accumulates, it triggers cell injury. Our laboratory has developed specific PAF antagonists and is using these tools to explore further its significance. We are also exploring a gene, the inducible prostaglandin synthase (COX-2). We have found that PAF induces this gene. The product of COX-2 accumulates in hippocampus in models of epilepsy, as well as in retina in light-induced photoreceptor degeneration.
The lab is also studying membrane biogenesis, in terms of the supply and trafficking of docosahexaenoic acid, a key building block in synapses and photoreceptors. In our studies of excitable membrane biogenesis, we have discovered that the essential fatty acid, docosahexaenoic acid, which is a major component of photoreceptors, is conserved by means of metabolic loops involving the liver and the interstitial space surrounding photoreceptors. These loops are altered in certain retinal degenerations and, possibly, also in some neurological diseases. The central hypothesis being explored is that lipid messengers mediate critical responses for cell survival. Phospholipases A2-generated messengers modulate both synaptic receptors, as well as downstream signaling through endogenous lipid neuroprotective messengers (e.g. docosanoids). Sites of pharma-cological action, as well as novel drugs acting on these informational pathways, are being identified. The essential docosahexaenoic acid, in addition, is the precursor of neuroprotectin D1 (NPD1).
This new lipid mediator is anti-inflammatory, a potent upregulator of Bcl-2 anti-apoptotic and a downregulator of Bcl-2 pro-apoptotic proteins. Our goal is to determine the crosstalk between synapses and genes, and between neurons and astrocytes, that modulate long-term responses, which could perhaps be pharmacologically manipulated to prevent or repair injury, inflammation and cellular damage occurring in diseases.
neuroprotection and neural/synaptic plasticity; unraveling cell survival signaling in injury and neurodegeneration; stroke; epilepsy; Alzheimer's disease; retinal degenerations; inflammatory response and resolution; omega-3 fatty acids; memory formation; cell signaling for successful aging
2012 ARVO Abstracts
Hill JM, Clement C, Mukherjee PK, Cui J-G, Li Y, Bhattacharjee S, McFerrin HE Jr, Bhattacharjee PS, Zhao Y, Lukiw WJ. Acyclovir attenuates stress-induced miRNA-146a levels in human retinal pigment epithelial (RPE) cells.
Calandria JM, Bazan NG. Ataxin-1 poly-q-induced proteotoxic stress and apoptosis are attenuated by docosahexaenoic acid-derived neuroprotectin D1 in human retinal pigment epithelial cells.
Bazan NG. Choroidal neovascularization: Role of neuroprotectin D1.
Yang Z, Li S, Jin M. Dual pathogenic basis for the retinitis pigmentosa-associated IRBP.
Knott EJ, Gordon WC, Bazan NG. Docosahexaenoic acid is incorporated into ARPE-19 cells and involves modulation of pro- and anti-apoptotic proteins pMAPK, pAKT308, and BIM.
Bazan NG. Mediator lipidomics in the cornea and retina: Targets for modulation of inflammation, neuroprotection and nerve regeneration.
Cortina MS, He J, Russ T, Erickson J, Bazan N, Bazan HE. Corneal nerve damage induces epithelial localization of vesicular glutamate transporter-2 (vglut2).
He J, Bazan HP. Altered corneal nerve architecture in epithelial basement membrane dystrophy.
Russ TC, He J, Bazan NG, Bazan HE. NPD1 and PEDF + DHA enhance neurite outgrowth and projection of trigeminal ganglion neurons towards corneal epithelial cells.
Kenchegowda S, Zang C, Bazan NG, Bazan HE. Increased release of pigment epithelial-derived factor after corneal injury stimulates neuroprotectin D1 synthesis.
Puthula S, Bazan HE, Chandrasekher G. Modulation of cell division cycle protein Cdc42 expression and its ser71 phosphorylation by Erk and PI-3 kinase signaling in corneal epithelial cells.
Lentz JJ, Jodelka FM, Hinrich AJ, McCaffrey KE, Farris HE, Bazan NG, Duelli DM, Rigo F, Hastings ML. Correction of cryptic splicing in Usher syndrome using antisense oligonucleotides.
Bazan NG, Berry KZ, Gordon WC, Knott EJ, Regan CE Jr, Murphy RC, Jun B. Spatial distribution of lipid molecular species in photoreceptors and other cells by maldi imaging mass spectrometry of the human retina.
Sheline C, Bai S. Light-induced retinal damage: Role of dietary zinc and zinc binding proteins.
Lukiw WJ, Bhattacharjee S, Alexandrov PN, Zhao Y, Dua P, Keryanov S. Regulation of complement factor H (CFH; chr 1q32) by multiple micro RNAs (miRNAs) I human brain and retina.
Bhattacharjee S, Hill JM, Pogue AI, Lukiw WJ. Retinal amyloid peptides and complement factor H (CFH) in transgenic models of Alzheimer’s disease (AD).
Li S, Izumi T, Lee J, Zhou Y, Gordon WC, Hill JM, Bazan NG, Miner JH, Jin M. Elongation of very long chain fatty acids protein 1 (ELOVL1) and fatty acid transport protein 4 (FATP4) are inhibitors of RPE65.
Kakazu AH, He J, Russ TC, Bazan HE. Lipoxin A4 (lxa4) decreases platelet-activating factor (PAF) inflammatory response and in turn stimulates corneal wound healing.
Stark DT, Knott EJ, Bazan NG. The morphonuclear analysis imaging method (MAIM): an unbiased approach to quantifying apoptosis in ARPE-19 cells demonstrates NPD1-induced inhibition of cell death.
Mukherjee PK, Litner DE, Alvarez-Builla J, Bazan NG. Interleukin aβ-mediated upregulation of proinflammatory genes are selectively inhibited by a platelet-activating factor antagonist in human retinal pigment epithelial cells.
Gordon WC, Knott EJ, Bazan NG. Docosahexaenoic acid potentiates pigment epithelium derived factor-induced protection in ARPE-19 cells.
Caviness LA, Mukherjee PK, Knott EJ Jr, Bazan NG. Characterization of primary cultures from adult retinal pigment epithelial cells (hrpe) and protection mediated by docosahexaenoic acid (dha).
Jun B, Knott EJ, Zhang C, Bazan NG. The further opening of the DHAS Metabolome in retinal pigment epithelial (RPE) cells: Maresin synthesis diverges from NPD1synthesis by enhanced oxidative stress.
Manalac J, Mukherjee PK, Bazan NG. Pigment epithelial derived factor (PEDF) and docosahexaenoic acid (DHA) induce antioxidant responsive element (ARE) upregulation in retinal pigment (ARPE-19) cells.
Zhou Y, Regan CE Jr, Gordon WC, Bazan NG. The application of ex vivo optical coherence tomography in a rat model of light damage.
Balaszczuk V, Mukherjee PK, Bazan NG. Iduna is a neuroprotectin D1 (npd1) target in retinal pigment epithelial cell survival signaling.
Sheets KG, Gordon WC, Bazan NG. Topical NPD1 promotes microglia ramification in experimental CNV.
Clement C, Thompson HW, Bhattacharjee PS, McFerrin HE Jr, Lukiw WJ, Corbin-Lickfett K, Empig CJ, Schlunegger K, Hill JM. Efficacious clinical outcome of an ophthalmic formation of phosphatidylserine-binding monoclonal antibody in a rabbit model of acute HSV-1 keratitis.
Asatryan A, Calandria JM, Bazan NG. Neuroprotectin D1 is a transcriptional modulator of the Birc3 gene that encodes an inhibitor of apoptosis protein in retinal pigment epithelial cells.
McFerrin HE Jr, Kristie TM, Bloom DC, Clement C, Bhattacharjee PS, Foster T, Lukiw WJ, Thompson HW, Hill JM. A monoamine oxidase inhibitor (tranylcypromine) blocks the shedding of infectious HSV-1 in the rabbit eye model.
Dr. Nicolas G. Bazan with Dr. Amanda Henne
The Oxygen Revolution with Dr. Harch and Dr. Bazan
- YouTube 082311
CIHR Training Program in Neurodegenerative Lipidomics: Ask me about Lipidomics
Dr. Nicolas Bazan - 110809
Retinal Degenerative Diseases 2016, Volume 854 of the series Advances in Experimental Medicine and Biology pp 385-391
Molecular Principles for Decoding Homeostasis Disruptions in the Retinal
Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseas
Hong, S.H. , Khoutorova, L., Bazan, N.G., and Belayev, L; Docosahexaenoic Acid Improves behavior and Attenuates Blood-Brain Barrier Injury Induced by Focal Cerebral Ischemia in Rats.Experimental and Tranlsational Stroke Medicine (2015) 7:3:1-10.
Rice, D.S. Calandria, J.M., Gordon, W.C., Jun, B.K., Zhou, Y.D., Gelfman, C.M., Li, S.H., Jin, M., Knott, E.J., Chang, B., Abuin, A., Issa El-Samman, T., Potter, D., Platt, K.A., and Bazan, N.G. Adiponectin Receptor 1 Conserves Docosahexaenoic Acid and Promotes Photoreceptor Cell Survival, Nature Communications, 2015 1-14
Calandria, J.M., Asatryan, A., Balaszczuk, V., Knott, E.J., Jun, B.K., Mukherjee, P.K., Belayev, L., and Bazan, N.G. NPD1-Mediated Steroselective Regulation of BIRC3 Expression Through cREL is Decisive for Neural Cell Survival, 2015, Cell Death and Differentation, 1-15.
Eady, T.N., Khoutorova, L.,Obenaus, A., Mohd-Yusof, A., Bazan, N.G., Belayev, L. Docosahexaenoic Acid complexed to albumin provides neuroprotection after experimental stroke in aged rats;Neurobiology of Disease; 62:1-7, 2014.
Docosahexaenoic Acid and its derivative Neuroprotectin D1 Display Neuroprotective Properties in the Retina, Brain and Central Nervous System. Makrides M. Ochoa JB, Szajewska H (eds): The Importance of Immunonutrition. Nestlé Nutr Inst Workshop Ser, Vol 77, pp 121-131, (DOI: 10.1159/000351395) Nestec Ltd., Vevey/S.Karger AG., Basel, c 2013.
Erickson, J.D., Bazan, N.G. The Nucleolus Fine-tunes the Orchestration of an Early Neuroprotection Response in Neurodegeneration. Cell Death Differ. 2013.
Sheets, K.G., Jun, B., Zhou, Y., Zhu, M., Petasis, N.A., Gordon, W.C., Bazan, N.G. Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. Mol Vis.2013;19:1747-59.
Songhua Li, Jungsoo Lee, Yongdong Zhou, William C. Gordon, James M. Hill, Nicolas G. Bazan, Jeffrey H. Miner, and Minghao Jin. Fatty Acid Transport Protein 4 (FATP4) Prevents Light-Induced Degeneration of Cone and Rod Photoreceptors by Inhibiting RPE65 Isomerase; The Journal of Neuroscience, 2013, 3178:33(7):3178 –3189.
Lentz, J., Jodelka, F.M., Hinrick, A.J., McCaffrey, K.E., Farris, H.E., Spalitta, M.J., Bazan, N.G., Duelli, D.M., Rigo, F., Hastings, M.L. Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness; Nature Medicine Advance Published Online February 2013 1-8.
Eady, T.N., Khoutorova, L., Atkins, K.D., Bazan, N.G., Belayev, L. Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window.Exp Transl Stroke Med. 2012 Sep 14;4(1):19. doi: 10.1186/2040-7378-4-19.
Eady, T.N., Khoutorova, L., Atkins, K.D., Bazan, N.G., Belayev, L. Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window. Exp Transl Stroke Med. 2012 Sep 14;4(1):19. doi: 10.1186/2040-7378-4-19.
Bazan, N.G. Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. Mol Neurobiol. 2012 Aug;46(1):221-6. doi: 10.1007/s12035-012-8322-5. Epub 2012 Sep 7.
Petasis, N.A., Yang, R., Winkler, J.W., Zhu, M., Uddin, J., Bazan, N.G., Serhan, C.N. Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Lett. 2012 Apr 4;53(14):1695-1698. Epub 2012 Jan 14.
Bazan, N.G., Eady, T.N., Khoutorova, L., Atkins, K.D., Hong S., Lu, Y., Zhang C., Jun, B., Obenaus A., Fredman, G., Zhu, M., Winkler, J.W., Petasis, N.A., Serhan, C.N., Belayev, L. Novel aspirin-triggered Neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol. 2012 Jul; 236(1):122-30. Epub 2012 Apr 19.
Calandria, J.M., Mukherjee, P.K., Vaccari, J., Zhu, M., Petasis, N.A., Bazan, N.G. Ataxin-1 Poly-Q-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotection D1. J Biol Chem. 2012 Jul 6; 287(28):23726-39. Epub 2012 Apr 16.
Petasis, N.A., Yang, R., Winkler, J.W., Zhu, M., Uddin, J., Bazan, N.G., Serhan, C.N. Stereocontrolled total synthesis of Neuroprotectin D1/Protectin D1 and its aspirin-triggered stereoisomer, Tetrahedron Letters 2012 53:1695-1698.
Stark, D.T., Bazan, N.G. Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal COX-2 function, lipid peroxidation, and neuroprotection. J Neurosci. 2011 31:13710-13721.
Zhou, Y., Sheets, K.G., Knott, E.J., Regan, C.E. Jr., Tuo, J., Chan, C.C., Gordon, W.C., Bazan, N.G.
Cellular and 3D Optical Coherence Tomography Assessment During the Initiation and Progression of Retinal Degeneration in the Ccl2/Cx3cr1-deficient Mouse. Exp. Eye Res. 2011 93:636-648.
Cortina, M.S., He, J., Li, N., Bazan, N.G., Bazan, H.E. Recovery of corneal sensitivity, CGRP positive nerves and increased wound healing are induced by PEDF plus DHA after experimental surgery. Arch. Ophthal. 2012 130:76-83; 2011 (online first).
Molina, M.F., Bazan, N.G. The bioactive mediator neuroprotectin D1 derived from docosahexaenoic acid is a homeostatic cell survival sentinel in the nervous system. ASBMB Today July 2011 pp.24-25.
Musto, A.E., Gjorstrup, P., Bazan, N.G. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia. 2011 52:1601-1608.
Mattson, M.P., Bazan, N.G. Apoptosis and Necrosis. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Belayev, L., Lu, Y. M., Bazan, N.G. Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Halabi, A., Ertel, M., Petasis, N.A. Neuroinflammation. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Stark, D.T., Petasis, N.A. Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Molina, M.F., Gordon, W.C. Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's and other Neurodegenerative Diseases. Annual Review of Nutrition 2011 31:321-51.
Stark, D.T., Bazan, N.G. Protectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. Mol Neurobio, (2011) 2:131-8.
Kenchegowda, S., Bazan, N.G., Bazan, H. E. EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.Invest Ophthalmol Vis Sci. (2011) 6:52:2240-9.
He, J., Kakazu, A.H., Bazan, N.G., Bazan, H.E. Aspirin-Triggered Lipoxin A4 (15-epi-LXA4) Increases the Endothelial Viability of Human Corneas Storage in Optisol-GS. J Ocul Pharmacol Ther. 2011 27:235-241.
Zhao, Y., Calon, F., Julien, C., Winkler, J.W., Petasis, N.A., Lukiw, W.J., Bazan, N.G. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PLoS One. (2011) 6:e15816.
Belayev, L., Khoutorova, L., Atkins, K.D., Eady, T.N., Hong, S., Lu, Y., Obenaus, A., Bazan, N.G. Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke. Transl Stroke Res. (2011) 2:33-41.
Knott, E.J., Sheets, K.G., Zhou, Y., Gordon, W.C., Bazan, N.G. Spatial correlation of mouse photoreceptor-RPE thickness between SD-OCT and histology. Exp Eye Res. (2011) 92:155-60.
Lukiw, W.J., Bazan, N.G. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol. 2010 42:10-16
Bazan, N.G., Calandria, J.M., Serhan, C.N. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. (2010) 51:2018-31.
Halapin, N.A., Bazan, N.G. NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling. Neurochem Res. (2010) 35:1944-7.
Cui, J.G., Bazan, N.G. Agrin downregulation induced by nerve injury contributes to neuropathic pain. J. Neurosci. (2010) 30:15286-15297.
He, J., Bazan, N.G., Bazan, H.E. Mapping the entire human corneal nerve architecture. Exp Eye Res. (2010) 91:513-523.
Palacios-Pelaez, R., Lukiw, W.J., Bazan, N.G. Omega-3 essential Fatty acids modulate initiation and progression of neurodegenerative disease. Mol. Neurobiol. (2010) 41:367-374.
Lukiw, W.J., Bazan, N.G. Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis.Mol. Neurobiol. (2010) 42:10-16.
Antony, R., Lukiw, W.J., Bazan, N.G. Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival. J. Biol. Chem. (2010) 285:18301-18308.
Faghiri, Z., Bazan, N.G. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp. Eye Res. (2010) 90:718-725.
Sheets, K.G., Zhou, Y., Ertel, M.K., Knott, E. J., Regan, C. E., Elison, J.R., Gordon, W.C., Gjorstrup, P., N.G. Bazan. Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. Mol Vis. (2010) 16:320-329.
Marcheselli, V.L., Mukherjee, P.K., Arita, M., Hong, S., Antony, R., Sheets, K., Winkler, J.W., Petasis, N.A., Serhan, C.N., Bazan, N.G. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids. (2010) 82:27-34.
Calandria, J.M., Bazan, N.G. Neuroprotectin D1 Modulates the Induction of Pro-Inflammatory Signaling and Promotes Retinal Pigment Epithelial Cell Survival During Oxidative Stress. Adv Exp Med Biol. 664 (2010) 663-670. (Review)
Zhang, C., Bazan, N.G. Lipid-mediated cell signaling protects against injury and neurodegeneration. J Nutr. (2010) 140:858-863. (Review)
Niemoller, T.D., Bazan, N.G. Docosahexaenoic acid neurolipidomics. Prostaglandins Other Lipid Mediat. (2010) 91:85-89. (Review)
Cortina, M.S., He, J., Li, N., Bazan, N.G, Bazan, H.E. Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA. Invest Ophthalmol Vis Sci. (2010) 51:804-810.
Calandria, J.M., Bazan, N.G. Neuroprotectin D1 modulates the induction of pro-inflammatory signaling and promotes retinal pigment epithelial cell survival during oxidative stress. In: Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations. Advances in Experimental Medicine and Biology. Vol. 664. Eds: R. E. Anderson, J. G. Hollyfield, M. M. LaVail. (2010) Ch. 76:663-670.
Calandria, J.M., Marcheselli, V.L., Mukherjee, P.K., Uddin, J., Winkler, J.W., Petasis, N.A., Bazan, N.G. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J Biol Chem. (2009) 284:17877-17882.
Belayev, L., Khoutorova, L., Atkins, K.D., Bazan, N.G. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke. (2009) 40:3121-3126.
Belayev, L., Khoutorova, L., Atkins, K., Cherqui, A., Alvarez-Builla, J., Bazan, N.G. LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat. Brain Res. (2009) 1253:184-190.
Esquenazi, S., He, J., Li, N., Bazan, N.G, Esquenazi, I., Bazan, H.E. A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory mediators in mice exposed to desiccating conditions after PRK. Clin Dev Immunol. (2009) 2009:138513.
Bazan, N.G. Is NF-kappa B from astrocytes a decision maker of neuronal life or death? (Commentary on Dvoriantchikova et al.). Eur J Neurosci. (2009) 30:173-174. Commentary
Bazan, N.G. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids. (2009) 81:205-211. (Review)
Niemoller, T.D., Stark, D.T., Bazan, N.G. Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system. World Rev Nutr Diet. (2009) 99:46-54. (Review)
Bazan, N.G. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. J Lipid Res. (2009) 50:Suppl:S400-S405. (Review)
Bazan, N.G. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids. (2009) 81:205-211.
Bazan, N.G. Cell Signaling by Polyunsaturated Fatty Acids in Epileptogenesis. In: Philip A. Schwartzkroin, editor, Encyclopedia of Basic Epilepsy Research, Vol 2. Oxford: Academic Press; 2009. pp. 703-712.
Bazan, N.G., and Musto A.E. Inositol Lipid Signaling in Synaptic Activity, Neuronal Plasticity and Epileptogenesis. In: Philip A. Schwartzkroin, editor Encyclopedia of Basic Epilepsy Research, Vol 3. Oxford: Academic Press; 2009. pp. 1160-1166.
Belayev, L., Khoutorova, L., Atkins, K., Gordon, W.C., Alvarez-Builla, J., Bazan, N.G. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. (2008) 214:253-258.
Lukiw, W.J., Bazan, N.G. Docosahexaenoic acid and the aging brain. J Nutr. (2008) 138:2510-2514. (Review)
Van Meter, K., Sheps, S., Kriedt, F., Moises, J., Barratt, D., Murphy-Lavoie, H., Harch, P.G., Bazan, N.G. Hyperbaric oxygen improves rate of return of spontaneous circulation after prolonged normothermic porcine cardiopulmonary arrest. Resuscitation (2008) 78:200-214.
Bazan, N.G. Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv Exp Med Biol. (2008) 613:39-44.
Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D., Bazan, N.G. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci USA. (2007) 104:13152-13157.
Mukherjee, P.K., Marcheselli, V.L., de Rivero Vaccari, J.C., Gordon, W.C., Jackson. F.E., Bazan, N.G. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc Natl Acad Sci USA. (2007) 104:13158-13163.
Mukherjee, P.K., Chawla, A., Loayza, M.S., Bazan, N.G. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Prostaglandins Leukot Essent Fatty Acids. (2007) 77:233-238.
Bazan, N.G. Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. Invest Ophthalmol Vis Sci. (2007) 48:4866-4881.
Ryan, S.D., Harris, C.S., Mo, F., Lee, H., Hou, S.T., Bazan, N.G, Haddad, P.S., Arnason, J.T., Bennettm, S.A. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem(2007) 103:88-97.
Esquenazi, S., He, J., Li, N., Bazan, N.G., Esquenazi, I., Bazan, H.E. Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stromal cells in mice with and without dry eye after photorefractive keratectomy. Clin Experiment Ophthalmol. (2007) 35:545-549.
Kolko, M., Prause, J.U., Bazan, N.G., Heegaard, S. Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases, Acta Ophthalmol Scand. (2007) 85:317-323.
Cui, J.G., Zhang, X., Zhao, Y.H., Chen, C., Bazan, N.G. Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. Biochem Biophys Res Commun 350:358-363, 2006. Erratum in: Biochem Biophys Res Commun. (2007) 359:187-188.
Vaccarino, A.L., Paul, D., Mukherjee, P.K., Rodríguez de Turco, E.B., Marcheselli, V.L., Xu, L., Trudell, M.L., Minguez, J.M., Matía, M.P., Sunkel, C., Alvarez-Builla, J., Bazan, N.G. Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs. Bioorg Med Chem. (2007) 15:2206-2215.
Kolko, M., Wang, J., Zhan, C., Poulsen, K.A., Prause, J.U., Nissen, M.H., Heegaard, S., Bazan, N.G. Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci. (2007) 48:1401-1409.
Bazan, N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care. (2007) 10:136-141.
Bazan, N.G. Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv Exp Med Biol. (2006) 572:531-540.
Lukiw, W.J., Bazan, N.G. Survival signalling in Alzheimer's disease. Biochem Soc Trans. (2006) 34:1277-1282.
Cole-Edwards, K.K., Musto, A.E., Bazan, N.G. c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes. J Neurosci(2006) 26:8295-8304.
Bazan, N.G. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol. (2006) 26:901-913.
Lukiw, W.J., Mukherjee, P.K., Cui, J.G., Bazan, N.G. A2E selectively induces COX-2 in ARPE-19 and human neural cells. Curr Eye Res. (2006) 31:259-263.
Kolko, M., Christoffersen, N.R., Barreiro, S.G., Miller, M.L., Pizza, A.J., Bazan, N.G. Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. J Neurosci Res. (2006) 83:874-882.
Musto, A., Bazan, N.G. Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. Epilepsia. (2006) 47:267-276.
He J., Bazan N.G., Bazan H.E. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. (2006) 124:70-78.
Faghiri, Z., Bazan, N.G. Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. Invest Ophthalmol Vis Sci. (2006) 47:397-404.
Esquenazi, S., He, J., Kim, D.B., Bazan, N.G., Bui, V., Bazan, H.E. Wound-healing response and refractive regression after conductive keratoplasty. J Cataract Refract Surg. 32:480-486, 2006.
Chen, C., Hardy, M., Zhang, J., LaHoste, G.J., Bazan, N.G. Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments. Biochem Biophys Res Commun. (2006) 10;340:435-440.
McDermott, C.M., Hardy, M.N., Bazan, N.G., Magee, J.C. Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J Physiol. (2006) 1;570:553-65.
Malcher-Lopes, R., Di, S., Marcheselli, V.S., Weng, F.J., Stuart, C.T., Bazan, N.G., Tasker J.G. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci. (2006) 26:6643-6650.
Ruskin, D.N., Dunn, K.E., Billiot, I., Bazan, N.G., Lahoste, G.J. Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze. Life Sci. (2006) 78:2833-2838.
Esquenazi, S., He, J., Bazan, H.E., Bazan, N.G. Use of autologous serum in corneal epithelial defects post-lamellar surgery. Cornea. (2005) 24:992-997.
Cole-Edwards, K.K., Bazan, N.G. Lipid signaling in experimental epilepsy. Neurochem Res. (2005) 847-853 (Review).
Tian, X., Bazan, N.G. Neuroprotection by platelet-activating factor antagonism. Ann N Y Acad Sci. (2005) 1053:455-456 (Review).
Kolko, M., Christoffersen, N.R., Varoqui, H., Bazan, N.G. Expression and induction of secretory phospholipase A2 group IB in brain. Cell Mol Neurobiol. (2005) 25:1107-1122.
Lukiw, W.J., Pappolla, M., Pelaez, R.P., Bazan, N.G. Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism. Cell Mol Neurobiol(2005) 25:475-483 (Review).
Chen, C., Bazan, N.G. Endogenous PGE 2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol(2005) 93:929-941.
Mattson, M.P., Bazan, N.G. Apoptosis and necrosis., Basic Neurochemistry 7 th edition, G. Siegel, R. W. Albers, S. T. Brady, D. L. Price (eds.), (2005).
Zhu, P., Genc, A., Zhang, X., Zhang, J., Bazan, N.G, Chen, C. Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors. J Neurosci Res (2005) 15;81:817-826.
Bazan, N.G. Synaptic signaling by lipids in the life and death of neurons. Mol Neurobiol(2005) 31:219-230 (Review).
Bazan, N.G. Neuroprotectin D1 (NPD1): A DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol(2005) 15:159-166 (Review).
Bazan, N.G., Marcheselli, V.L., Cole-Edwards, K. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci. (2005) 1053:137-147 (Review).
Chen, C., Bazan, N.G. Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid. Mediat. (2005) 77:65-76 (Review).
Bazan, N.G. Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol. (2005) 32:89-103 (Review).
Sang, N., Zhang, J., Marcheselli, V.L., Bazan, N.G., Chen, C. Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. J Neurosci. (2005) 26;25:9858-9870.
Di, S., Boudaba, C., Popescu, I.R., Weng, F.J., Harris, C., Marcheselli, V.L., Bazan, N.G., Tasker, J.G. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol. (2005) 5;569:751-760.
Lukiw, W.J., Cui, J.G., Musto, A.E., Musto, B.C., Bazan, N.G. Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun. (2005) 9;338:77-81.
Esquenazi, S., He, J., Bazan, N.G., Bazan, H.E. Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy. J Cataract Refract Surg. (2005) 31:1632-1639.
Esquenazi, S., Bazan, H.E., Bui, V., He, J., Kim, D.B., Bazan, N.G. Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. Invest Ophthalmol Vis Sci. (2005) 46:3121-3127.
Di, S., Malcher-Lopes, R., Marcheselli, V.L., Bazan, N.G., Chen, C. Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology. (2005) 146:4292-4301.
Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G.Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res(2005) 81:742-750.
Teather, L.A., Packard, M.G., Smith, D.E., Ellis-Behnke, R.G., Bazan, N.G. Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks. Neurobiol Learn Mem(2005) 84:75-84.
Boedker, M., Boetkjaer, A., Bazan, N.G., Cui, J.G., Zhao, Y., Pelaez, R.P., Lukiw, W.J. Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. Neurosci Lett (2005) 20-27;380:176-180.
Sharma, G.D., Ottino, P., Bazan, N.G., Bazan, H.E. Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J Biol Chem(2005) 4;280:7917-7924.
Lukiw, W.,Cui, J.G., Marcheselli, V., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., Bazan, N.G. A role for docosahexaenoic acid-derived neuroprotection D1 in neural cell survival and Alzheimer’s disease. J Clin Inv. (2005) 115:2774-2783.
Belayev, L., Marcheselli, V.L., Khoutorova, L., Rodriguez de Turco, E.B., Busto, R., Ginsberg, M.D., Bazan, N. G. Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke(2005) 36:118-123.
Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G. Neuroprotectin D1: A docosahexanoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci, USA (2004) 101:8491-8496.
Ottino, P., Finley, J., Rojo, E., Ottlecz, A., Lambrou, G.N., Bazan, H.E., Bazan, N.G. Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells. Involvement of cytosolic phospholipase A(2) activity. Mol Vis (2004) 10:341-350.
Zhu, P., DeCoster, M.A., Bazan, N.G. Interplay among platelet-activating factor, oxidative stress, and group I metabotropic, glutamate receptors modulates neuronal survival. J Neurosci Res (2004) 77:525-531.
Cui, J.G., Kuroda, H., Chandrasekharan, N.V., Pelaez, R.P., Simmons, D.L., Bazan, N.G., Lukiw, W. J. Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem Res(2004) 29:1731-1737.
Rollin, S., Lemieux, C., Maliba, R., Favier, J., Villeneuve, L.R., Allen, B.G., Soker, S., Bazan, N.G., Merhi, Y., Sirois, M.G. VEGF-mediated endothelial P-selectin translocation: Role of VEGF receptors and endogenous PAF synthesis. Blood(2004) 103:3789-3797.
Axelrad, T.W., Deo, D.D., Ottino, P., Van Kirki, J., Bazan, N.G., Bazan, H.E.P., Hunt, J.D. Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration.FASEB J (2004) 18:568-570.
Deo, D.D., Bazan, N.G., Hunt, J.D. Activation of platelet-activating factor (PAF) receptor-coupled Ga q leads to stimulation of Src and focal adhesion kinase (FAK) via two separate pathways in human umbilical vein endothelial cells (HUVEC). J Biol Chem 279:3497-3508, 2004.
Ma, X., Ottino, P., Bazan, H.E., Bazan, N.G. Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. Invest Ophthalmol Vis Sci. (2004)45:2915-2921.
Kolko, M., Christoffersen, N.R., Barreiro, S.G., Bazan, N.G. Expression and location of mRNAs encoding multiple forms of secretory phospholipase A 2 in the rat retina. J Neurosci Res (2004) 77:517-524.
Katsura, K., Rodriguez de Turco, E.B., Siesjö, B.K., Bazan, N.G. Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. Brain Res(2004) 1030:133-140.
Tu, B., Bazan, N.G. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenases-2 expression in neocortex. Exp. Neurol. (2003) 179:167-175.
Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G. DNA repair in photoreceptor survival. Mol Neurobiol(2003) 28:111-122 (Review).
McDermott, C., LaHoste, G.J., Chen, C., Musto, A., Bazan, N.G., Magee, J.C. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci(2003) 23:9687-9695.
Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronert, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G. Novel docosanoids inhibit brain ischema-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem (2003) 278:43807-43817.
Bazan, N.G. Synaptic lipid signaling: Significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res(2003) 44:2221-2233.
Lukiw, W.J., Ottlecz, A., Lambrou, G., Grueninger, M., Finley, J., Thompson, H.W., Bazan, N.G. Coordinate activation of HIF-1 and NF-KappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investi Ophthalmol and Vis Sci(2003) 44:4163-4170.
Chen, C., Bazan, N.G. Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT 2 receptor. NeuroReport(2003) 14:743-747.
Kolko, M., Rodriguez de Turco, E.B., Diemer, N.H., Bazan, N.G. Neuronal damage by secretory phospholipase A2: Modulation of cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. Neurosci Lett(2003) 338:164-168.
Bazan, N.G. and Flower, R.J. Lipid signals in pain control. Nature (2002) 420:135-138. (News and Views).
Bazan, N.G. and Lukiw, W.J. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1 beta and amyloid-beta 42 peptide is potentiated by hypoxia in primary human neural cells. J Biol Chem(2002) 277:30359-30367.
Gordon, W.C., Casey, D.M., Lukiw, W.J., Bazan, N.G. DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci(2002) 43:3511-3521.
Rodriguez de Turco, E.B., Belayev, L., Liu, Y., Busto, R., Parkins, N., Bazan, N.G., Ginsberg, M.D. Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin. J Neurochem(2002) 82:1-10.
DeCoster, M.A., Lambeau, G., Lazdunski, M., Bazan, N.G. Secreted phospholipase A 2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J Neurosci Res (2002) 67:634-645.
Rodriguez de Turco, E.B., Jackson, F.R., DeCoster, M.A., Kolko, M., Bazan, N.G. Glutatmate signaling and secretory phospholipase A 2 modulate the release of arachidonic acid from neuronal membrane. J Neurosi Res(2002) 68:558-567.
Teather, L.A., Packard, M.A., Bazan, N.G. Post-training cyclooxygenase-2 (COX) inhibition impairs memory consolidation. Learning and Memory(2002) 9:41-47.
Deo, D.D., Axelrad, T.W., Robert, E.G., Marcheselli, V.L., Bazan, N.G, Hunt, J.D. Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells: Evidence for a dual kinase mechanism. J Biol Chem (2002) 277:21237-21245.
Parker, M.A., Bazan, H.E.P., Marcheselli, V.L., Rodriguez de Turco, E.B., Bazan, N.G. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J Neurosci Res (2002) 68:39-50.
Chen, C., Magee, J.C., Bazan, N.G. Cyclooxygenase-2 regulates prostaglandin E 2 signaling in hippocampal long- term synaptic plasticity. J Neurophysiol(2002) 87:2851-2857.
Kolko, M., Nielsen, M., Bazan, N.G., Diemer, N. Secretory phospholipase A 2 induces delayed neuronal COX-2 expression as compared to glutamate. J Neurosci Res (2002) 69:169-177.
Bazan, N.G., Tu, B., Rodriguez de Turco, E.B. What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. Prog Brain Res(2002) 135:175-185, (Review).
Rodriguez de Turco, E.B., Tan, W., Tophan, M.K., Sakane, F., Marcheselli, V.L., Chen, C., Taketomi, A., Prescott, S., Bazan, N.G. Diacylglycerol kinase epsilon regulates seizures susceptibility and long term potentiation through inositol lipid signaling. Proc Natl Acad Sci(2001) 98:4740-4745.
Bazan, N.G.COX-2 as a multifunctional neuronal modulator. Nature Medicine(2001) 7:414-415, (News and Views).
Chen, C., Magee, J.C., Marcheselli, V.L., Hardy, M., Bazan, N.G. Attenuated long-term potentiation in hippocampal dentate gyrus neurons of mice deficient in the platelet-activating factor receptor. J Neurophysiol(2001) 85:384-390.
Lukiw, W.J., Carver, L.A., LeBlanc, H.J., Bazan, N.G. Analysis of 1184 gene transcript levels in Alzheimer CA1 hippocampus: synaptic signaling and transcription factor deficits and upregulation of pro-inflammatory pathways. Alzheimer’s Reports(2000) 3:143-149.
Lukiw, W.J., Rogaev, E.I., Bazan, N.G. Potential of transcriptional coordination of nine genes associated with Alzheimer’s disease. Alzheimer’s Reports(2000) 3:231-242.
Ershov, A.V., Bazan, N.G. Photoreceptor phagocytosis selectively activates PPARa expression in retinal pigment epithelial cells. J Neurosci Res(2000) 60:328-337.
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochem. Biophys. Acta 218:1-10, 1970. Selected as "This Week's Citation Classic" (1991).
PDF with links for Dr. Bazan's publications 1963 to 2012
“Neuroprotection: Lipid Signaling in Ischemia-Reperfusion”
Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institute for Neurological Disorders and Stroke,
National Institutes of Health (R01 NS046741)
"Molecular Logic of Neuronal Adaption for Survival"
Principal Investigator: Nicolas G. Bazan, M.D., Ph.D.
Grant: 2011 National Institutes of Health Directors Pioneer Award
Funding Agency: National Institutes of Health
"Neuroprotective Bioactivity of Neuroprotectin D1 with Nanoparticle-Enhanced Delivery in Experimental Retinal Degeneration"
Nicolas G. Bazan, M.D., Ph.D.
Agency: Beckman Initiative for Macular Research; The Arnold and Mabel Beckman Foundation, Doheny Eye Institute (1101)
“Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience”
Principal Investigator: Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institutes of Health, National Center for Research Resources (P20 RR016816)
“NPD1 promotes survival signaling in the Ccl2-/-/Cx3cr1-/- mouse AMD model”
Nicolas G. Bazan, M.D., Ph.D.
Agency: American Health Assistance Foundation
“Mechanism of action of omega-3 fatty acids in brain injury”
Nicolas G. Bazan, M.D., Ph.D. (LSUHSC)
Charles N. Serhan, Ph.D. (Harvard)
Nicos A. Petasis, Ph.D. (USC)
Agency: National Institutes of Health, National Center for Complementary and Alternative Medicine (RC2 AT005909)
“Neuroprotectin D1 slows photoreceptor degeneration”
Nicolas G. Bazan, M.D., Ph.D.
Agency: Foundation Fighting Blindness (TA-NP-0808-0463-LSUNO)
“RPE Messengers, Transcription and Photoreceptor Renewal”
Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institutes of Health, National Eye Institute (R01 EY005121)