2014%2011:57:05%20AM

Jason Gardner, Ph.D.

Associate Professor

1901 Perdido Street
New Orleans, LA 70112
Phone: 504 568-7252
Fax: 568-6158

jgardn@lsuhsc.edu

Degrees

Ph.D. Biomedical Engineering
Louisiana Tech University, Ruston

Research Interests My major research focus is the pathogenesis of heart failure.
Of particular interest are the mechanisms responsible for adverse cardiac extracellular matrix (ECM) remodeling associated with the progression of congestive heart failure.
Current topics of study include:
the role of lysyl oxidase, a collagen crosslinking enzyme, and related peptides in myocardial ECM remodeling,
the cardioprotective effects of estrogenic pathways, including soybean- and plant-derived compounds, and
the cardiac effects of inhaled particulate matter and cigarette smoke.
My laboratory utilizes rodent models of cardiac disease, including models of pressure and volume overload.
We also use primary adult cell culture to examine specific pathways involved in the remodeling process.
Selected Publications

Molina, P.E., J.D. Gardner, F.M. Souza-Smith, and A.M. Whitaker. Alcohol Abuse: Critical Pathophysiological Processes and Contribution to Disease Burden. Physiology (Bethesda), 29(3): 203-15, 2014.

Siddesha, JM., A.J. Valente, S.S. Sakamuri, J.D. Gardner, P. Delafontaine, M. Noda, B. Chandrasekar. Acetylsalicylic Acid Inhibits IL-18-Induced Cardiac Fibroblast Migration through the Induction of RECK. J Cell Physiol., 229(7):845-55, 2014.

El Hajj, E.C., M.C. El Hajj, T.G. Voloshenyuk, A.J. Mouton, E. Khoutorova, P.E. Molina, N.W. Gilpin, and J.D. Gardner. Alcohol Modulation of MMP and TIMP Expression in the Heart Favors Collagen Accumulation, Alcoholism: Clinical and Experimental Research, 38(2): 448-56, 2014.

Bradley, J.M., K.A. Cryar, M.C. El Hajj, E.C. El Hajj, and J.D. Gardner. Exposure to Diesel Exhaust Particulates Induces Cardiac Dysfunction and Remodeling. Journal of Applied Physiology, 115(7):1099-106, 2013.

Bradley, J.M., J.B. Nguyen, A.C. Fournett, and J.D. Gardner. Cigarette smoke exacerbates ventricular remodeling and dysfunction in the volume overloaded heart, Microscopy and Microanalysis, 18(1):91-8, 2012.

Valente A.J., T. Yoshida, J.D. Gardner, N. Somanna, P. Delafontaine, and B. Chandrasekar. Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1, Cell Signal., 24(2):560-8, 2012.

Nagalla K.T., M. Gole, M.A. Claudino, J.D. Gardner, and D.B. Murray.  Alteration in myocardial prostaglandin D synthase expression in pressure overload-induced left ventricular remodeling in rats, Exp Biol Med, 237(1):24-30, 2012.

Voloshenyuk T.G., A.D. Hart, E. Khoutorova, J.D. Gardner. TNF-α increases cardiac fibroblast lysyl oxidase expression through TGF-β and PI3Kinase signaling pathways, Biochem Biophys Res Commun, 413(2):370-5, 2011.

Voloshenyuk T.G., E.S. Landesman, E. Khoutorova, A.D. Hart, and J.D. Gardner. Induction of Cardiac Fibroblast Lysyl Oxidase by TGF-b1 Requires PI3K/Akt, Smad3, and MAPK Signaling, Cytokine, 55(1):90-7, 2011.

Voloshenyuk, T.G. and J.D. Gardner. Estrogen Improves TIMP-MMP Balance and Collagen Distribution in Volume-overloaded Hearts of Ovariectomized Females., AJP: Reg., Integ. and Comp., 299(2):R683-93, 2010.

Gardner, J.D., D.B. Murray, T.G. Voloshenyuk, G.L. Brower, J.M. Bradley, and J.S. Janicki.  Estrogen Attenuates Chronic Volume Overload Induced Structural and Functional Remodeling in Male Rat Hearts, AJP: Heart and Circ, 298(2):H497-504, 2010.

Gardner, J.D., G.L. Brower, T.G. Voloshenyuk, J.S. Janicki., Cardioprotection in female rats subjected to chronic volume overload: synergistic interaction of estrogen and phytoestrogens., AJP: Heart and Circ. 294(1):H198-204, 2008.

Murray, D.B., J.D. Gardner, G.L. Brower, J.S. Janicki., Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats., AJP: Heart and Circ. 294(3):H1251-7, 2008.

Levick, S.P., J.D. Gardner, M. Holland, M. Hauer-Jensen, J.S. Janicki, G.L. Brower., Protection from adverse myocardial remodeling secondary to chronic volume overload in mast cell deficient rats., JMCC 45(1):56-61, 2008.

Murray, D.B., J.D. Gardner, S.P. Levick, G.L. Brower, L.G. Morgan, J.S. Janicki., Response of cardiac mast cells to atrial natriuretic peptide., AJP: Heart and Circ. 293(2):H1216-22, 2007.

Csiszar, A., N. Labinskyy, K.E. Smith, A. Rivera, E.N. Bakker, H. Jo, J. Gardner, Z. Orosz, Z. Ungvari., Downregulation of bone morphogenetic protein 4 expression in coronary arterial endothelial cells: role of shear stress and the cAMP/protein kinase A pathway., Arterioscler Thromb Vasc Biol. 27(4):776-82, 2007.

Janicki J.S., G.L. Brower, J.D. Gardner, M.F. Forman, J.A. Stewart Jr, D.B. Murray, A.L. Chancey., Cardiac mast cell regulation of matrix metalloproteinase-related ventricular remodeling in chronic pressure or volume overload., Cardiovasc Res. 69(3):657-65, 2006.

Gardner, J.D., G.L. Brower and J.S. Janicki., Effects of dietary phytoestrogens on cardiac remodeling secondary to chronic volume overload in female rats., J. Appl. Physiol. 99(4):1378-83, 2005.

Additional Info

Curriculum Vitae