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Administration Basic Sciences Clinical Sciences Centers of Excellence

 

Nicholas Warren Gilpin, Ph.D.

Assistant Professor of Physiology

1901 Perdido Street
Box P7-3, Room 7258
New Orleans, LA 70112
 
Phone: (504) 568-6171

Fax: (504) 568-6158

ngilpi@lsuhsc.edu

Lab Website
 

Degrees

B.A.    Psychology    05/2000    UT-Austin

M.S.    Psychology    08/2003    Purdue Univ.

Ph.D.   Psychology    05/2006    Purdue Univ.

Research Interests

My lab utilizes animal models to identify the underlying neurobiological mechanisms of alcohol dependence and stress disorders. We work to understand the neurophar-macology of drug reinforcement in the drug-dependent organism, and we are also interested in examining the neurobiological mechanisms of co-dependence on more than one drug. To answer these questions, we use techniques that include operant drug self-administration, acoustic startle reflex, tests of pain and mechanosensitivity, tests of anxiety-like behavior and locomotor activity, alcohol and nicotine vapor inhalation for induction of physical dependence, behavioral pharmacology, immunohistochemistry, and Western blots.

Teaching Activities

Physiological Psychology/Behavioral Neuroscience, Animal

Learning, Motivation, Psychopharmacology, Statistics

Selected Publications
  1. Gilpin NW, Karanikas CA, Richardson HN. (2012) Adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats . PLoS One. 2012;7(2):e31466.

  2. Gilpin, N.W., Roberto, M. (2011) Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. Neuroscience & Biobehavioral Reviews.

  3. Gilpin, N.W.(2011) Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): Effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors. Alcohol.

  4. Gilpin, N.W. , Misra, K., Herman, M.A., Cruz, M.T., Koob, G.F., Roberto, M. (2011) Neuropeptide Y opposes alcohol effects on GABA release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry, 69, 1091-9.

  5. Gilpin, N.W., Koob, G.F. (2010) The β-adrenoceptor antagonist propranolol blocks dependence-induced increases in alcohol drinking. Psychopharmacology, 212, 431-9.

  6. Roberto M., Cruz M.T., Gilpin N.W., Sabino V., Schweitzer P., Cottone P., Madamba S.M., Stouffer D., Zorrilla E.P., Koob G.F., Siggins G.R., Parsons L.H. (2010) Neuroadaptation of CRF & GABA function in the amygdala: key mediator of alcohol dependence. Biological Psychiatry, 67, 831-9.

  7. Gilpin, N.W., Smith, A., Cole, M., Weiss, F., Koob, G.F., Richardson, H.N. (2009) Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats.Alcoholism: Clinical and Experimental Research, 33, 2113-23.

  8. Gilpin, N.W., Richardson, H.N., Lumeng, L., Koob, G.F. (2008). Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcoholism: Clinical and Experimental Research, 32, 1688-96.

  9. Roberto, M., Gilpin, N.W., O’Dell, L.E., Morse, A.C., Siggins, G.R., Koob, G.F. (2008). Cellular and behavioral rationale for gabapentin treatment of alcohol dependence. Journal of Neuroscience, 28, 5762-71.

  10. Gilpin, N.W., Misra K., Koob G.F. (2008). Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology, Biochemistry & Behavior, 90, 475-80.
Additional Info

Curriculum Vitae  
 

PubMed Link