song hong new for web 031213

Song Hong, Ph.D.

Professor of Research, Neuroscience, Biochemistry, Cell and Molecular Biology, and Ophthalmology

Neuroscience Center of Excellence
School of Medicine, LSU Health
8th floor, Room 8A7
2020 Gravier St., Suite D
New Orleans, LA 70112

Phone: (504) 599-0335 (O);



1996-2001: Postdoctoral training - Cornell University,
New York

1996: PhD - The University of Georgia




2023-Present: Professor, Neuroscience, Biochemistry, Cell & Molecular Biology, and Ophthalmology.
Neuroscience Center of Excellence and Dept of Ophthamology
LSU Health Sciences Center, New Orleans, LA

2012-2023: Associate Professor, Neuroscience, Biochemistry, Cell & Molecular Biology, and Ophthalmology.
Neuroscience Center of Excellence and Dept of Ophthamology
LSU Health Sciences Center, New Orleans, LA

2018-present: Adjunct faculty, Diabetes Research, Tulane Medical School, Tulane University

2006-2012: Assistant Professor of Neuroscience, Biochemistry, Cell and Molecular Biology, and Ophthalmology.
Neuroscience Center of Excellence and Dept of Ophthalmology
LSU Health Sciences Center, New Orleans, LA 

2004-2006: Instructor (a junior faculty rank), Harvard Medical School, Boston, MA

2001-2004: Research fellow, Harvard Medical School, Boston, MA

Clinical Interests

Current Research:

1) Our major objective is to elucidate new mechanisms and explore the therapeutic potential of endogenous reparative linflammation-resolving lipid mediators in diabetes and aging-impaired wound healing and in the regenerative functions of cells, angiogenesis, severe burns, and Alzheimer’s diseases. Our studies include the biochemical metabolic pathways and signaling of lipid mediators in diabetic wounds and burn injury.  My work also includes the development of therapeutic leads and biomarkers for these disorders. We intend to decipher the roles of novel lipid mediators in the key cellular and molecular processes including inflammation, neurodegeneration, neurogenesis, innervation, phagocytosis/efferocytosis, microgliosis, astrogliosis, blood brainbarrier, vascularization/angiogenesis, epithelialization, and fibrosis. 2) We are also developing novel hydrogels, nanoparticles, and microparticles for wound healing and nerve regeneration. 3) We have been studying specialized pro-resolving and neuroprotective lipid mediators in Alzheimer's disease.


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Research Interests


Wound healing, chronic wounds impaired by diabetes and aging, diabetic neurophathy, nerve regeneration and degeneration, Alzheimer's disease, neuron outgrowth, resolution of chronic inflammation, pro-healing lipid autacoids, pro-resolving reparative lipid mediators, mediator-lipidomic pathways, vasculogenesis, angiogenesis, fibrosis, phagocytosis, efferocytosis, wound healing, wound breaking strength, scarring, diabetic nephropathy, renal acute injury, leukocytes, neurons, microglial cells, astrocytes, spinal cord, dorsal root ganglions, macrophages, monocytes, dendritic cells, neutrophils, mesenchymal stem cells, adipose stem cells, platelets, endothelial cells, epithelial cells, T-cells, hydrogels, nanoparticles, and microparticles.


Research Interests and Goals:

Our long term goals are: 1) To delineate the actions, roles, and mechanisms of lipid mediators and mediator-lipidomic pathways that regulate wound healing and other reparative processes impaired by diabetes and aging as well as the pathogenesis of Alzheimer's disease. 2) To study the machanisms of these lipid mediators in other diabetic complications (neuropathy, nephropathy, and retinopathy) and Alzheimer's disease. 3) To provide new targets for better treatment of diabetic complications and Alzheimer's disease.

Our short-term goals are: 1) To elucidate the mechanism of action of endogenous reparative pro-reoslving lipid mediators in curbing the pathogesis of Alzheimer's disease and diabetic impairments of wound healing, in promoting re-innervation, vascularization, and integraty of blood brain barrier.  We will also determine lipid-mediator based signatures of human non-healing chronic wounds. 2) To study the interaction of lipid mediators and stem cells or leukocytes in chronic wounds. 3) To study lipid mediators in ocular diseases.

Teaching Activities

  1. NEURO 203 - Investigavtive Neuroscience

  2. NCE 290 - Special Topics

  3. NEURO 250 - Molecular Neurobiology
  4. CSI 100 and CSI 200 – School of Medicine House Mentorship Program


Committees & Administrative Responsibilities

  • LSUHSC Research Advisory Committee
  • LSUHSC Sabbatical Committee
  • LSUHSC Graduate Advisory Committee
  • LSUHSC Communication Committee


  • Current Editorial Board Membership
    • International Journal of Stem cell research & Therapy
    • Prostaglandins, Leukotrienes, Essential Fatty Acids
    • International Journal of Surgery Research & Practice
    • International Journal of Hematology Research
    • SM Journal of Orthopedics
    • Annals of Diabetes, Metabolic Disorders & Control
    • The Open Biomarkers Journal
    • Current Regenerative Medicine (CRM)
    • Bioengineering 

Selected Publications

Key Peer-reviewed Publications
(Selected from 67 peer-reviewed publications)

1. Lu Y, Tian H, Peng H, Bazan NG, Hong S. Novel lipid mediator 7S,14R-docosahexaenoic acid: biogenesis and harnessing mesenchymal stem cells to ameliorate diabetic mellitus and retinal pericyte loss. Frontiers Cell Dev Biol. 12 Epub 12 March 2024. doi: 10.3389/fcell.2024.1380059

2. Thamizhchelvan AM, Masoud A-R, Su S, Peng H, Kobayashi Y, Wang Y, Archer N, Hong S. Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria. International Journal of Molecular Sciences. 2024;25(5):2792. doi:

3. Baravkar, S.B.; Lu, Y.; Masoud, A. R.; Zhao, Q.;, He, J.; Hong, S., Development of a Novel Covalently Bonded Conjugate of Caprylic Acid Tripeptide (Isoleucine–Leucine–Aspartic Acid) for Wound-Compatible and Injectable Hydrogel to Accelerate Healing. biomolecules. 2024, 14(1), 94. doi: 10.3390/biom14010094. PMID: 38254694; PMCID: PMC10813153. 

4. Hong, S.; Nagayach, A., Lu Y.; Peng, H.; Duong, Q.A.; Pham, N.B.; Vuong, C.A.; Bazan, N.G., A high fat, sugar, and salt Western diet induces motor-muscular and sensory dysfunctions and neurodegeneration in mice during aging: Ameliorative action of metformin. CNS Neurosci Ther. 2021 Dec;27(12):1458-1471. doi: 10.1111/cns.13726. PMID: 34510763; PMCID: PMC8611779.

5. Ogawa N, Sone S, Hong S., Lu Y, Kobayashi Y. Synthesis of Two Stereoisomers of Potentially Bioactive 13,19,20-Trihydroxy Derivative of Docosahexaenoic Acid. Synlett. 2020 Oct;31(17):1735-1739. doi: 10.1055/s-0040-1706415. PMID: 35023886; PMCID: PMC8752060.

6. Hong, S.*, Lu, Y., Morita, M., Saito, S., Kobayashi, Y., Jun, B., Bazan, N.G., Xu, X., Wang, Y.,   Stereoselective Synthesis of Maresin-Like Lipid Mediators. Synlett. 2019, 30 (03) 343-347 DOI: 10.1055/s-0037-1612011. PMID: 31086432; PMCID: PMC6510270

7. Alapure, B.V., Lu, Y., He, M., Chu, C.C., Peng, H., Muhale, F., Brewerton, Y.L., Bunnell, B., Hong, S.*, Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan. Stem cells and development.  2018,27(23):1605-1620. PMID: 30215325   PMCID:PMC6276600

8. Alapure, B. V.; Lu, Y.; Peng, H.; Hong, S.*, Surgical denervation of specific cutaneous nerves impedes excisional wound healing of small animal ear pinnae. Mol Neurobiol, 2018, 55(2): 1236-1243. PMCID: PMC5577384  PMID: 28110472.

9. Nishimura, K.; Sakaguchi, T.; Nanba, Y.; Suganuma, Y.; Morita, M.; Hong, S.; Lu, Y.; Jun, B.; Bazan, N. G.; Arita, M.; Kobayashi, Y., Stereoselective Total Synthesis of Macrophage-Produced Prohealing 14,21-Dihydroxy Docosahexaenoic Acids. The Journal of organic chemistry. 2018; 83(1):154-166. PMID: 29224348 PMCID: PMC8607632.

10. Bazan, H. A.; Lu, Y.; Jun, B.; Fang, Z.; Woods, T. C.; Hong, S.*, Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease. Prostaglandins, leukotrienes, and essential fatty acids. 2017; 125:43-47. PMID: 28987721 PMCID: PMC5909403.

11. Hong, S. *; Tian, H.; Lu, Y.; Laborde, J. M.; Muhale, F. A.; Wang, Q.; Alapure, B. V.; Serhan, C. N.; Bazan, N. G., Neuroprotectin/Protectin D1: Endogenous Biosynthesis and Actions on Diabetic Macrophages in Promoting Wound Healing and Innervation Impaired by Diabetes. Am J Physiol Cell Physiol, 2014, 307, (11): C1058-67. PMCID: PMC4254953. PMID: 25273880.

12. Hong, S.*; Lu, Y.; Tian, H.; Alapure, B. V.; Wang, Q.; Bonnell, B.; Laborde, J. M., Leukocytes and Platelets Produce Novel Maresin-like Docosanoids Structure, Biosynthesis, and Effect on Diabetes-impaired Macrophage Reparative Function. Chemistry & Biology (Cell at Cell Press), 2014, 21, (10): 1318-29. PMCID: PMC4224612. PMID:25200603.

13. Hong, S.*; Alapure, B. V.; Lu, Y.; Tian, H.; Wang, Q., 12/15-Lipoxygenase deficiency reduces densities of mesenchymal stem cells in the dermis of wounded and unwounded skin. Br J Dermatol, 2014, 171, (1), 30-8. PMCID:PMC4114990. PMID: 24593251.

14. Hong, S*.; Alapure, B. V.; Lu, Y.; Tian, H.; Wang, Q., Immunohistological localization of endogenous unlabeled stem cells in wounded skin. J Histochem Cytochem, 2014, 62, (4), 276-85. PMCID: PMC3966289. PMID: 24399040.

15. Hong, S.*; Lu, Y., Omega-3 fatty acid-derived resolvins and protectins in inflammation resolution and leukocyte functions: targeting novel lipid mediator pathways in mitigation of acute kidney injury. Front Immunol,2013, 4, 13. PMCID:PMC3558681. PMID: 23386851.

16. Tian, H.; Lu, Y.; Shah, S. P.; Wang, Q.; Hong, S.*, 14S,21R-dihydroxy-docosahexaenoic Acid Treatment Enhances Mesenchymal Stem Cell Amelioration of Renal Ischemia/Reperfusion Injury. Stem Cells Dev, 2012, 21, (7), 1187-99. PMCID:PMC3328765. PMID: 21846180.

17. Bazan, N. G.; Eady, T. N.; Khoutorova, L.; Atkins, K. D.; Hong, S.; Lu, Y.; Zhang, C.; Jun, B.; Obenaus, A.; Fredman, G.; Zhu, M.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Belayev, L., Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol,2012, 236, (1), 122-30. PMCID: PMC3409566. PMID: 22542947.

18. Belayev, L.; Khoutorova, L.; Atkins, K. D.; Eady, T. N.; Hong, S.; Lu, Y.; Obenaus, A.; Bazan, N. G., Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke. Transl Stroke Res,2011, 2(1), 33-41. PMCID: PMC3037476. PMID: 21423332.

19. Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Autacoid 14S,21R-dihydroxy-docosahexaenoic acid counteracts diabetic impairment of macrophage prohealing functions. Am J Pathol, 2011, 179, (4), 1780-91.PMCID:PMC3181353. PMID: 21839062.

20.  Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, 14S,21R-Dihydroxydocosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds. J Biol Chem, 2011, 286, (6), 4443-53. PMCID:PMC3039401. PMID: 21112969.

21.  Tian, H.; Lu, Y.; Shah, S. P.; Hong, S.*, Novel 14S,21-dihydroxy-docosahexaenoic acid rescues wound healing and associated angiogenesis impaired by acute ethanol intoxication/exposure. J Cell Biochem, 2010, 111, (2), 266-73. PMCID:PMC3308707. PMID: 20506249.

22.  Lu, Y.; Tian, H.; Hong, S.*, Novel 14,21-dihydroxy-docosahexaenoic acids: structures, formation pathways, and enhancement of wound healing. J Lipid Res2010, 51, (5), 923-32. PMCID:PMC2853460. PMID:19965612.

23.  Marcheselli, V. L.; Mukherjee, P. K.; Arita, M.; Hong, S.; Antony, R.; Sheets, K.; Winkler, J. W.; Petasis, N. A.; Serhan, C. N.; Bazan, N. G., Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids, 2010, 82, (1), 27-34. PMCID:PMC2822836.PMID: 19931440,

24.  Tian, H.; Lu, Y.; Sherwood, A. M.; Hongqian, D.; Hong, S.*, Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. Invest Ophthalmol Vis Sci, 2009, 50, (8), 3613-20. PMID:19443724.

25. Bazan, H. A.; Lu, Y.; Thoppil, D.; Fitzgerald, T. N.; Hong, S.; Dardik, A., Diminished omega-3 fatty acids are associated with carotid plaques from neurologically symptomatic patients: implications for carotid interventions. Vascul Pharmacol, 2009, 51, (5-6), 331-336. PMCID: PMC2786054. PMID: 19733689.

26.  Hong, S.; Porter, T. F.; Lu, Y.; Oh, S. F.; Pillai, P. S.; Serhan, C. N., Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol, 2008, 180, (5), 3512-9. PMID:18292578.

27.  Bazan, N. G.; Marcheselli, V. L.; Lu, Y.; Hong, S.; Jackson, F., Lipidomic Approaches to Neuroprotection Signaling in the Retinal Pigment Epithelium. In Signal Transduction in the Retina, Fliesler, S. J.; Kisselev, O. G., Eds. CRC Press: 2007; pp 345-374.

28.  Hong, S.; Lu, Y.; Yang, R.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom, 2007, 18, (1), 128-44. PMCID:PMC2763184. PMID:17055291.

29.  Lu, Y.*; Hong, S.*; Yang, R.; Uddin, J.; Gotlinger, K. H.; Petasis, N. A.; Serhan, C. N., Identification of endogenous resolvin E1 and other lipid mediators derived from eicosapentaenoic acid via electrospray low-energy tandem mass spectrometry: spectra and fragmentation mechanisms. Rapid Commun Mass Spectrom, 2007, 21, (1), 7-22.  PMID:17131464.(*Share 1st authorship).

30.  Connor, K. M.; SanGiovanni, J. P.; Lofqvist, C.; Aderman, C. M.; Chen, J.; Higuchi, A.; Hong, S.; Pravda, E. A.; Majchrzak, S.; Carper, D.; Hellstrom, A.; Kang, J. X.; Chew, E. Y.; Salem, N., Jr.; Serhan, C. N.; Smith, L. E., Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med, 2007, 13, (7), 868-73. PMID:17589522.

31.  Lu, Y.*; Hong, S.*; Gotlinger, K.; Serhan, C. N., Lipid mediator informatics and proteomics in inflammation resolution. ScientificWorldJournal, 2006, 6, 589-614. PMID: 16752008. (*Share 1st authorship)

32.  Serhan, C. N.; Gotlinger, K.; Hong, S.; Lu, Y.; Siegelman, J.; Baer, T.; Yang, R.; Colgan, S. P.; Petasis, N. A., Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. J Immunol, 2006, 176, (3), 1848-59. PMID: 16424216.

33.  Duffield, J. S. *; Hong, S. *; Vaidya, V. S.; Lu, Y.; Fredman, G.; Serhan, C. N.; Bonventre, J. V., Resolvin D series and protectin D1 mitigate acute kidney injury.J  Immunol, 2006, 177, (9), 5902-11, PMID: 17056514. PMID: 17056514. (*Share 1st authorship)

34.  Hong, S.; Tjonahen, E.; Morgan, E. L.; Lu, Y.; Serhan, C. N.; Rowley, A. F., Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat, 2005, 78, (1-4), 107-16. PMID: 16303609.

35.  Lu, Y.*; Hong, S.*; Tjonahen, E.; Serhan, C. N., Mediator-lipidomics: databases and search algorithms for PUFA-derived mediators. J Lipid Res, 2005, 46, (4), 790-802. PMID:15722568. (*Share 1st authorship)

36.  Arita, M.; Bianchini, F.; Aliberti, J.; Sher, A.; Chiang, N.; Hong, S.; Yang, R.; Petasis, N. A.; Serhan, C. N., Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med, 2005, 201, (5), 713-22. PMCID:PMC2212834. PMID:15753205.

37.  Ariel, A.; Li, P. L.; Wang, W.; Tang, W. X.; Fredman, G.; Hong, S.; Gotlinger, K. H.; Serhan, C. N., The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem, 2005, 280, (52), 43079-86. PMID:16216871.

38. Vance, R. E.; Hong, S.; Gronert, K.; Serhan, C. N.; Mekalanos, J. J., The opportunistic pathogen Pseudomonas aeruginosa carries a secretable arachidonate 15-lipoxygenase. Proc Natl Acad Sci U S A, 2004, 101, (7), 2135-9. 17. PMCID:PMC357064. PMID:14766977.

39.  Marcheselli, V. L.*; Hong, S.*; Lukiw, W. J.; Tian, X. H.; Gronert, K.; Musto, A.; Hardy, M.; Gimenez, J. M.; Chiang, N.; Serhan, C. N.; Bazan, N. G., Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem, 2003, 278, (44), 43807-17. PMID:12923200. (*Share 1st authorship)

40. Hong, S.; Gronert, K.; Devchand, P. R.; Moussignac, R. L.; Serhan, C. N., Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J Biol Chem, 2003, 278, (17), 14677-87. PMID:12590139.

41.  Serhan, C. N.; Hong, S.; Gronert, K.; Colgan, S. P.; Devchand, P. R.; Mirick, G.; Moussignac, R. L., Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med, 2002, 196, (8), 1025-37. PMCID:PMC2194036. PMID:12391014.