Website Picture_Xiaolin Tian-p Xiaolin Tian, Ph.D.
 Assistant Professor – Research of Cell Biology and Anatomy and Neuroscience

Neuroscience Center of Excellence
School of Medicine, LSU Health

2020 Gravier Street, Suite D
New Orleans, LA 70112

Office: (504) 559-0912
Lab: (504) 568-2057
Fax: (504) 599-0891

 xtian@lsuhsc.edu

 

Degrees     

2000 – 2006:  Ph.D. in Developmental Biology,
Washington University in St. Louis, School of Medicine, USA

1992 – 1996:  B.S. in Biochemistry,
East China University of Science and Technology
Shanghai, China.                         

Short Bio

Feb, 2016 – Present
Assistant Professor-Research
Neuroscience Center of Excellence & Department of Cell Biology and Anatomy
Louisiana State University Health

Jan, 2009 – Jan, 2016
Postdoctoral Researcher,
Neuroscience Center of Excellence,
Louisiana State University Health

Jun. 2007 – Dec. 2008
Postdoctoral Researcher,
Department of Pathology and Immunology,
Washington University in St. Louis, School of Medicine

Research Interests

My research focuses on understanding how specific neurons and neural circuits regulate systemic aging. We recently identified a role of a small population of dopaminergic neurons in regulating longevity in fruit fly. Characterization of the aging-related dopaminergic circuits holds the key to understanding how brain orchestrates aging and lifespan control.

In addition to studying the link between the high-order brain circuits and aging, I am also interested in the cellular degradation pathways that promote cellular homeostasis. Malfunction in the clearance mechanisms contributes to a range of human diseases including neural developmental and neurodegenerative disorders. Our recent studies demonstrated that, Mask, a putative scaffolding protein with RNA binding capacity, play essential functions in the cell through its regulation on lysosome function and autophagic activity, as well as microtubule dynamics. Overexpressing Mask in specific neurons is beneficial to aging and neurodegeneration. Future studies will focus on unravelling the conserved mechanisms through which Mask confers beneficial effects in post mitotic neurons.

Keywords

Aging, Dopaminergic neurons, Neural Development, Neurodegeneration, Autophagy, Lysosomal Function, Microtubule Dynamics

Selected publications

  1. Xiaolin Tian*. Dopaminergic Neurons Regulate Aging and Longevity in Flies. BioRxiv Preprint (2020).
    (* Corresponding author)

  2. Mingwei Zhu, Daniel Martinez, Jessie J. Guidry, Niles Majeste, Hui Mao, Sarah Yanofsky, Xiaolin Tian* and Chunlai Wu.
    Mask, the Drosophila Ankyrin Repeat and KH domain-containing protein, regulates microtubule dynamics)
    * Corresponding author under Revision. (PLOS Genet, BioRxiv Preprint (2020).
    PLOS Genet, under Revision. (* Corresponding author)

  3. Mingwei Zhu, Sheng Zhang, Xiaolin Tian* and Chunlai Wu*. Mask mitigates MAPT- and FUS-induced degeneration by
    enhancing autophagy through lysosomal acidification
    . Autophagy (2017)1:1-15. (* Corresponding author)

  4. Xiaolin Tian and Chunlai Wu. Active zone stability: insight from fly neuromuscular junction.
    Neural Regeneration Research (2015) 10:677-678.

  5. Mingwei Zhu, Xia Li, Xiaolin Tian* and Chunlai Wu*.  Mask loss-of-function rescues mitochondrial impairment and muscle
    degeneration of Drosophila pink1 and parkin mutants
    . Human Molecular Genetics . (2015) 24(11):3272-85.
    (* Corresponding author)

  6. Xiaolin Tian , Mingwei Zhu, Long Li and Chunlai Wu. Identifying protein-protein interaction in Drosophila Adult heads by tandem
    affinity purification (TAP)
    . The Journal of Visualized Experiments (JOVE) (2013)82, e50968.

  7. Xiaolin Tian and Chunlai Wu. The role of ubiquitin-mediated pathways in presynaptic development and axonal
    regeneration: insights from fly and worm
    . The Journal of Physiology (2013) 591(Pt 13):3133-43.
    (* Corresponding author)

  8. Xiaolin Tian , Jing Li, Vera Valakh, Aaron DiAntonio and Chunlai Wu. Drosophila Rae1 controls the abundance of
    the ubiquitin ligase Highwire in post-mitotic neurons
    . Nature Neuroscience (2011)14:1267-1275.
    Featured Article (October, 2011).

  9. Xiaolin Tian, Ramon U. Jin, Andrew J. Bredemeyer, Edward J. Oates, Katarzyna M. Błażewska,
    Charles E. McKenna, and Jason C. Mills. RAB26 and RAB3D are direct transcriptional targets of
    MIST1 that regulate exocrine granule maturation
    . Molecular and Cellular Biology (2010) 30(5):1269-84.

  10. Xiaolin Tian , Dave Hansen, Tim Schedl and James B. Skeath. Epsin potentiates Notch pathway activity in Drosophila and C. elegans .
    Development (2004) 131(23): 5807-15.

Complete List of Published Work in MyBibliography:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection