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Diptasri Mandal, PhD

Associate Professor of Genetics

533 Bolivar Street
New Orleans, LA 70112
Phone: (504) 568- 6156
Fax: (504) 568-8500

dmanda@lsuhsc.edu

Familial Lung Cancer Study
Genetic Studies of Prostate Cancer
African American Family Study
General Population Family Study
 

Degrees

BSc Zoology - 1984
Calcutta University, Calcutta, India

MSc Zoology with specialization in Entomology - 1986
Burdwan University, Burdwan, India

MS Biology - 1991
University of Louisiana, Monroe, LA

PhD Human Genetics, Biometry minor - 1996
Louisiana State University Health Sciences Center (Advisor: Dr. Joan Bailey-Wilson)

Bio

 

Dr. Diptasri M. Mandal is an Associate Professor in the Department of Genetics at Louisiana State University Health Sciences Center. She received her PhD. in Human Genetics from the Department of Biometry and Genetics at LSU Health Sciences Center in 1996. She joined the Department of Medicine in 1997, and in June 2000 moved to the Department of Genetics.

The major focus of her research is genetic studies of complex human traits and diseases, especially cancer. Studies are underway to identify disease susceptible loci for hereditary prostate cancer and lung cancer using linkage and association analyses. She is an active member of International Consortium of Prostate Cancer Genetics (ICPCG) and Genetic Epidemiology of Lung Cancer Consortium (GELCC).


Her research also includes methodological studies of genetic analysis of complex traits using computer simulations to evaluate the performance of various linkage methods under realistic situations.

Research Interests

Genetic studies of complex traits/diseases such as prostate cancer, lung cancer, breast cancer, and endometriosis

Statistical genetic analysis methods through computer simulation

Teaching Activities

Course Director: Genetic Epidemiology and Population Genetics (Genet 236)
Lecturer: Control of Gene Expression (INTER 123), Cancer Molecular Genetics and Applications (Genet 245), and Cancer Epidemiology (Epid 6222)

 

Committees & Administrative Responsibilities

Departmental Committees

2002-present. Chair, Graduate Admission Committee

2009-2013. Chair, Promotion & Tenure Committee

2009-present. Chair. Graduate Student Oversight Committee

2010-present. Chair. Curriculum Committee

School  of Medicine Committees

2001-present. Member, Graduate Advisory Council

2003-present, Member, Council of Professional Conduct

2006-present. Chair, Curriculum Committee, Graduate School

2014-present. Senator, School of Graduate Studies

2014-present. Member, Graduate Advisory Council Research Committee

Professional Society Committee

2003-present. Ethical Legal Social Issues (ELSI) Committee, International Genetic Epidemiologic Society

 

Administrative Responsibilities

2000-present. Graduate Student Coordinator, Department of Genetics

Selected Publications

D.M. Mandal, A.F.Wilson, R.C. Elston, K. Weissbecker, B. J. Keats, J. E. Bailey-Wilson. Effect of misspecification of allele frequencies on the Type I error of model-free linkage analysis. Human Heredity. 2000. 50:126-132.

D. M. Mandal, A. F. Wilson and J. E. Bailey-Wilson. Effects of Misspecification of Allele Frequencies on the Power of Haseman-Elston Sib-pair Linkage Method for Quantitative Traits. American Journal of Medical Genetics. 2001.103:308-313.

J. E. Bailey-Wilson, C. I. Amos, S. Pinney, G. M. Petersen, M. de Andrade, J. S. Wiest, P. Fain, A. G. Schwartz, M. You, W. Franklin, C. Klein, A. Gazdar, H. Rothschild, D. M. Mandal, T. Coons, J. Slusser, J. Lee, C. Gaba, E. Kupert, A. Perez, X. Zhou, D. Zeng, Q. Liu, D. Seminara, J. Minna, M. Anderson. A major lung cancer susceptibility locus maps to chromosome 6q23-25. American Journal of Human Genetics. 2004. 75:460-484.

M. Wang, H. Vikis, Y. Wang, D. Jia, D. Wang, L. J. Bierut, J. E. Bailey-Wilson, C. I. Amos, S. M. Pinney, G. P. Peterson, M. de Andrade, P. Yang, J. S. Wiest, P. R. Fain, A. G. Schwartz, A. Gazdar, J. Minna, C. Gaba, H. Rothschild, D. M. Mandal, E. Kupert, D. Seminara, Y. Liu, J. Clark, M. Watson, A. Viswanathan, R. Govindan, M. W. Anderson, M. You. Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1. Cancer Research. 2007. 67:93-99.

D. M. Mandal, O. Sartor, S.L. Halton, D.E. Mercante, J.E. Bailey-Wilson, W. Rayford. Identification of Prostate Cancer Cases in Louisiana and a Comparison of Prostate Cancer Specific Clinical Data on African-American and Caucasian Males with and without Family History. Prostate Cancer and Prostatic Diseases. 2008. 11:274-279.

P. Liu, H.G. Vikis, D. Wang, Y. Lu, Y. Wang, A.G. Schwartz, S.M. Pinney, P. Yang, M. de Andrade, G.M. Petersen, J.S. Wiest, P.R. Fain, A. Gazdar, C. Gaba, H. Rothschild,  D.M. Mandal, T. Coons, J. Lee, E. Kupert, D. Seminara, J. Minna, J.E. Bailey-Wilson, M.R. Spitz, T. Eisen, R.S. Houlston, C.I. Amos, M.W. Anderson, M. You. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst. 2008. 100:1326-30.

M. You, D. Wang, P. Liu, H. Vikis, M. James, Y. Lu, Y. Wang, M. Wang, D. Jia, Y. Liu, L.J. Bierut, P. Yang, Z. Sun, Y. Wu, W. Zheng, X. Shu, J. Long, Y. Gao, Y. Xiang, W. Chow, N. Rothman, S.M. Pinney, G.M. Petersen, M. de Andrade, J.S. Wiest, P.R. Fain, A.G. Schwartz, A. Gazdar, C. Gaba, H. Rothschild, D. M. Mandal , J. Lee, E. Kupert, D. Seminara, J. Minna, J.E. Bailey-Wilson, C. I. Amos, and M.W. Anderson. RGS17 is a candidate for the lung cancer susceptibility locus on chromosome 6q23-25. Clinical Cancer Research.2009. 15:2666-74.

C.I. Amos, S.M. Pinney, Y. Li, E. Kupert, J. Lee, M.A. de Andrade, P. Yang, A.G. Schwartz, P.R. Fain, A. Gazdar, J. Minna, J.S. Wiest, D. Zeng, H. Rothschild, D. M. Mandal, M. You, T. Coons, C. Gaba, J.E. Bailey-Wilson, M.W. Anderson. A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers. Cancer Research. 2010. 70:2359-67.

E.M. Ledet, O. Sartor, W. Rayford, J.E. Bailey-Wilson, D.M. Mandal. Suggestive evidence of linkage identified at chromosomes 12q24 and 2p16 in African American prostate cancer families from Louisiana. Prostate. 2012. 72:938-47.

E.M. Ledet, X. Hu, O. Sartor, W. Rayford, M. Li, D. M. Mandal. Characterization of germline copy number variation in high-risk African American families with prostate cancer. Prostate. 2013. 73:614-23. 

C. L. Simpson, A. J. Goldenberg, R. Culverhouse, D. Daley, R. P. Igo, Jr., G. P. Jarvik, D. M. Mandal, D. Mascalzoni, C. G. Montgomery, B. Pierce, R. Plaetke, S. Shete, K. A. B. Goddard and C. M. Stein. Practical Barriers and Ethical Challenges in Genetic Data Sharing. Int. J. Environ. Res. Public Health. 2014. 11: 8383-8398.

Additional Info

Diptasri Mandal, PhD, Biosketch