Chuan-dong Geng Ph.D.

Research Assistant Professor

Department of Biochemistry & Molecular Biology 533 Bolivar Street Clinical Sciences Research Building Room 4B2 New Orleans, LA 70112 Phone: 504-568-7435 cgeng@lsuhsc.edu

Degrees

PhD Biochemistry and Molecular Biology Shanghai Institute of Biochemistry, Shanghai, Peoples Republic of China

Bio

Chuan-dong Geng received his doctoral degree from Shanghai Institute of Biochemistry (Shanghai, PRC) in 1999. Since then he has held the post of Postdoctoral Research Associate in the laboratory of Professor Wayne V. Vedeckis in Department of Biochemistry and Molecular Biology, at Louisiana State University Health Sciences Center, New Orleans, Louisiana. In 2005 Dr. Geng was promoted to Research Assistant Professor. His research focus is glucocorticoid induced apoptosis of B-cell acute lymphoblastic leukemia.

Research Interests

The glucocorticoid induced apoptosis of B-cell acute lymphoblastic leukemia

Selected Publications

Geng CD, Vedeckis WV.A New, Lineage Specific, Autoup-Regulation Mechanism for Human Glucocorticoid Receptor Gene Expression in 697 Pre-B-Acute Lymphoblastic Leukemia Cells.Mol Endocrinol. 2010 Nov 17. [Epub ahead of print]

Geng CD, Vedeckis WV. Use of Recombinant Cell-Permeable Small Peptides To Modulate Glucocorticoid Sensitivity of Acute Lymphoblastic Leukemia Cells.Biochemistry. Oct 19;49(41):8892-901; (2010) Open PDF of this articl

Geng CD, Schwartz JR, Vedeckis WV. A Conserved Molecular Mechanism Is Responsible For The Auto-Upregulation Of Glucocorticoid Receptor Gene Promoters. Mol Endocrinol. Oct 22; (2008)

Geng, C.-D. and Vedeckis W.V. C-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. J. Biol. Chem. 280: 43264-43271 (2005)

Geng, C.-D., Pedersen, K.B., Nunez, B.S. and Vedeckis, W.V. Human glucocorticoid receptor alpha transcript splice variants with exon 2 deletions: evidence for tissue- and cell type-specific functions. Biochemistry, 44: 7395-405 (2005)

Nunez, B.S., Geng, C.-D., Pedersen, K.B., Millro-Macklin, C.D. and Vedeckis, W.V. Interaction between the interferon signaling pathway and the human glucocorticoid receptor gene 1A promoter. Endocrinology, 146: 1449-1457 (2005)

Garg, R., Geng, C.-D., Miller, J.L., Callens, S., Tang, X., Appel, B. and Xu, B. Molecular cloning and characterization of the catalytic domain of zebrafish homologue of the ataxia-telangiectasia mutated gene. Mol. Cancer Res., 2: 348-353 (2004)

Pedersen, K.B., Geng, C.-D. and Vedeckis, W.V. Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line. Biochemistry, 43:10851-10858 (2004)

Breslin MB, Geng, C.-D. Vedeckis WV. Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol.Aug;15(8):1381-95 (2001)

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