Tadahide Izumi, PhD

Associate Professor of Otorhinolaryngology
Member, LSU Stanley S. Scott Cancer Center

533 Bolivar Street, 5th floor
New Orleans, LA 70112
Phone: (504) 568-4785
Fax: (504) 568-4460

tizumi@lsuhsc.edu

Degrees

BS Biology - 1987
Kyoto University, Kyoto, Japan

MS Radiation Biology - 1989
Kyoto University, Kyoto, Japan

PhD Radiation Biology - 1993
Kyoto University, Kyoto, Japan

Bio

Dr. Izumi received both a Bachelor of Science and a Masters of Science degree in biology from the Kyoto University in Koyto, Japan. He earned a Doctor of Philosophy degree in Radiation Biology also at the Kyoto University. Dr. Izumi's post-doctoral research was conducted in the Sealy Center for Molecular Science at the University of Texas Medical Branch. He joined the faculty at the Sealy Center for Molecular Science as an Assistant Professor in the Department of Human Biological Chemistry & Genetics. Dr. Izumi was the recipient of the Japan Ministry of Education Fellowship and seed money Fund from Sealy Center on Aging. He is presently as Assistant Professor in the School of medicine and a member of the Stanley S. Scott Cancer Center. Dr. Izumi's research interests include DNA damage and mutagenesis, specifically those generated by reactive oxygen species; mechanisms of cellular defense and DNA repair against the DNA damage in human cells and other organisms. He is currently the recipient of an NIH RO1 grant for 2003-2007 on - Repair of Oxidative DNA damage in mammalian cells.

Selected Publications

Mantha AK, Oezguen N, Bhakat KK, Izumi T, Braun W, Mitra S. Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1. J Mol Biol. 379:28-37, 2008.

Oezguen N, Schein CH, Peddi SR, Power TD, Izumi T, Braun W. A "moving metal mechanism" for substrate cleavage by DNA repair endonuclease APE-1. Proteins 68:313-323, 2007.

Peddi SR, Chattopadhyay R, Naidu CV, Izumi T. The Human Apurinic/Apyrimidinic Endonuclease-1 Suppresses Activation of Poly(ADP-ribose) Polymerase-1 Induced by DNA Single Strand Breaks. Toxicology 224:44-55, 2006.

Izumi T, Brown DB, Naidu CV, Bhakat KK, Macinnes MA, Saito H, Chen DJ, Mitra S. Two essential but distinct functions of the mammalian AP endonuclease 1. Proc. Natl. Acad. Sci. USA 102:5739-5743, 2005.

Balazs R, Izumi T and Mitra S, The Major Role of Human AP-endonuclease Homologue Apn2 in Repair of Abasic Sites in Schizosaccharomyces pombe., Nucleic Acids Res 32: 1-12, 2004.

Izumi T, Schein CH, Oezguen N, Feng Y and Braun W, Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1)., Biochemistry 43: 684-689, 2004.

Bhakat K, Izumi T, Yang S, Hazra T and Mitra S, Role of acetylated human AP-endonuclease (APE1/Ref1) in regulation of the parathyroid hormone gene., EMBO J 22: 6299-6309, 2003.

Izumi T, Wiederhold LR, Roy G, Roy R, Jaiswal A, Bhakat KK, Mitra S and Hazra TK, Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage., Toxicology 193: 43-65, 2003.

Hazra TK, Izumi T, Kow YW and Mitra S, The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications., Carcinogenesis 24:155-157, 2003.

Additional Info

Curriculum Vitae