Francesca Peruzzi, PhD

Associate Professor of Medicine

Section of Hematology/Oncology and Stanley S. Scott Cancer Center
1700 Tulane Avenue, Room 711
New Orleans, LA 70112
tel: (504) 210-2978
fperuz@lsuhsc.edu

Degrees

PhD in Biological Science - 1992
University of Sienna
Sienna, Italy

PhD in Molecular and Quantitative Diagnostic Pathology - 2006
University of Sienna
Sienna, Italy

Postdoctoral Fellowship in Microbiology and Immunology – 1997
Temple University School of Medicine
Philadelphia, PA

Postdoctoral Fellowship in Cell Biology – 1994
University of Camerino
Camerino, Italy.

Bio

Dr. Peruzzi joined the faculty of LSU School of Medicine in 2010 following seven years on faculty at Temple University School of Medicine in Philadelphia, PA. Before that, she worked as a Research Associate in the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia. She is a member of the International Society for Neurovirology and the Society for Neuroscience.

Selected Publications

Gualco E, Peruzzi F, Sweet T, Khalili K, Reiss K, Del Valle L. IGF-IR– dependent activation of Survinvin supports proliferation and prevents apoptosis of neuronal progenitors expressing viral oncoprotein, JCV T-antigen (submitted).

Gualco E, Wang JY, Del Valle L, Urbanska K, Peruzzi F, Khalili K, Amini S, Reiss K. IGF-IR in neuroprotection and brain tumors. Front Biosci. 2009 Jan 1;14:352-75

Passiatore G, Rom S, Eletto D, and Peruzzi F. HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity. BBA Molecular Cell Research, Oct 31, 2008. Epub ahead of print.

Darbinian N, Darbynian A, Czernik M, Peruzzi F, Khalili K, Reiss K, Gordon J, Amini S. HIV-1 Tat inhibits NGF-Induced Egr-1 transcriptional activity and consequent p35 expression in neural cells. J Cell Physiol. 2008 Feb 4

Wang JY, Gualco E, Peruzzi F, Sawaya BE, Passiatore G, Marcinkiewicz C, Staniszewska I, Ferrante P, Amini S, Khalili K, Reiss K. Interaction between serine phosphorylated IRS-1 and beta1-integrin affects stability of neuronal processes. J. Neurosci. Res. 2007 Aug 15; 85(11):2360-73.

Rubin R, Arzumanyan A, Soliera AR, Ross B, Peruzzi F, Prisco M. Insulin receptor substrate (IRS) -1 regulates murine embryonic stem (mES) cells self-renewal. J Cell Physiol. 2007 213(2):445-53.

Darbinian-Sarkissian N, Czernik M, Peruzzi F, Gordon J, Rappaport J, Reiss K, Khalili K, Amini S. Dysregulation of NGF-signaling and Egr-1 expression by Tat in neuronal cell culture. J. Cell Physiol. June 1, 2006.

Peruzzi F. The multiple functions of HIV-1 Tat: proliferation versus apoptosis. Frontiers in Biosciences, 2006 Jan 1; 11: 708-717.

Wang JY, Grabacka M, Marcinkiewicz C, Staniszewska I, Peruzzi F, Khalili K, Amini S, and Reiss K. The involvement of α1β1 integrin in IGF-I-mediated protection of PC12 neuronal processes from TNFα-induced injury. J. Neurosci. Res. 2006 Jan 1; 83(1):7-18.

Center of Excellence

Stanley S. Scott Cancer Center