Luis Del Valle, MD

Associate Professor of Pathology


1901 Perdido Street, Box P5-1
New Orleans, LA 70112 

Stanley S. Scott Cancer Center
1700 Tulane Avenue

LCRC, Suite 612
New Orleans, LA 70112



M.D. - Universidad Nacional Autonoma de México, México D.F. México





Residency: Pathology, Hospital General de México & Universidad Nacional Autónoma de México, México D.F. México

Post-doctoral Fellowship: Neuropathology, Thomas Jefferson University, Philadelphia, Pennsylvania USA

Post-doctoral Fellowship: Neurovirology, Temple University School of Medicine, Philadelphia, Pennsylvania USA

Clinical Interests



Research Interests


Polyomaviruses (JCV, Merkel Cell Polyomavirus),
Progressive Multifocal Leukoencephalopathy,
Glial Brain Tumors,
Viral Oncogenesis
DNA Damage and Repair mechanisms

Teaching Activities

Pathology 200 Course (LSU School of Medicine)
   Neuropathology I: Introduction to Neuropathology
   Neuropathology IV: Cerebro-Vascular diseases
   Neuropathology V: Demyelinating diseases
   Neuropathology VI: Neuro-Degenerative diseases
   Neuropathology VII: Brain Tumors

Pathology Residents

Selected Publications


10209983.         Khalili K, Krynska B, Del Valle L, Katsetos CD, and Croul S. (1999).  Medulloblastomas and the human neurotropic polyomavirus JC virus.  Lancet; 353 (9159): 1152-1153

10500209.         Krynska B, Del Valle L, Croul S, Gordon J, Katsetos CD, Carbone M, Giordano A, and Khalili K. (1999).  Detection of human neurotropic JC virus DNA sequences and expression of the viral oncogenic protein in pediatric medulloblastomas.  Proceedings of the National Academy of Sciences USA; 96 (20): 11,519-11,524

10602409.         Bonvetch R, Croul S, Richardson MW, Lorenzana C, Del Valle L, Alexander GM, Amini S, Morgello S, Khalili K, and Rappaport J. (1999). Role of HIV-1 Tat and CC chemokine MIP-1 a in the pathogenesis of HIV associated Central Nervous System disorders.  Journal of NeuroVirology; 5 (6): 685-694

10878711.          Del Valle L, Croul S, Morgello S, Amini S, Rappaport J, and Khalili K. (2000).  Detection of HIV-1 Tat and JCV capsid protein, VP1, in AIDS brain with Progressive Multifocal Leukoencephalopathy.  Journal of Neurovirology; 6 (3): 221-228

10936089.         Krynska B, Del Valle L, Gordon J, Otte J, Croul S, and Khalili K. (2000). Identification of a novel p53 mutation in JCV-induced mouse Medulloblastoma.  Virology; 274 (1): 65-74

11039901.         Gordon J, Del Valle L, Otte J, and Khalili K. (2000). Pituitary neoplasia induced by expression of human neurotropic Polyomavirus, JCV, early genome in transgenic mice.  Oncogene; 19 (42): 4840-4846

11117551.          Del Valle L, Azizi A, Krynska B, Enam S, Croul S, and Khalili K. (2000).  Reactivation of human neurotropic JC virus expressing oncogenic protein, in a recurrent Glioblastoma multiforme.  Annals of Neurology; 48 (6): 932-936

11358858.          Del Valle L, Gordon J, Assimakopoulou M, Katsetos CD, Geedes J, Varakis JN, Croul S, and Khalili K. (2001).  Detection of JC virus DNA sequences and expression of the viral regulatory protein T-Antigen in tumors of the central nervous system.  Cancer Research; 61 (10): 4287-4293

11577176.          Del Valle L, Behring J, Lorenzana C, Giordano A, Khalili K, and Croul S. (2001).  Expression of a polyoma virus oncoprotein and tumor suppressor proteins in medulloblastomas.  Journal of Clinical Pathology; Molecular Pathology; 54 (5): 331-337

11854388.          Del Valle L, Gordon J, Enam S, Delbue S, Croul S, Abraham S, Radhakrishnan S, Assimakopoulou M, Katsetos CD, and Khalili K. (2002).  Expression of human neurotropic polyomavirus JCV late gene product Agnoprotein in human medulloblastoma.  Journal of the National Cancer Institute; 94 (4): 267-273

11877394.         Lassak A, Del Valle L, Peruzzi F, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen.  Journal of Biological Chemistry; 277 (19): 17,231-17,238

11914404.          Del Valle L, Delbue S, Gordon J, Enam S, Croul S, Ferrante P, and Khalili K. (2002).  Expression of JC virus T-Antigen in a multiple sclerosis patient with a Glioblastoma multiforme.  Neurology; 58 (6): 895-900

12060623.          Del Valle L, Enam S, Lassak A, Wang JY, Croul S, Khalili K, and Reiss K. (2002).  Insulin-like Growth Factor 1 receptor activity in human medulloblastomas.  Clinical Cancer Research; 8 (6): 1822-1830

12429619.          Del Valle L, Enam S, Lara C, Ortiz-Hidalgo C, Katsetos CD, and Khalili K. (2002).  Detection of JC polyomavirus DNA sequences and cellular localization of T-Antigen and Agnoprotein in oligodendrogliomas.  Clinical Cancer Research; 8 (11): 3332-3340

12471454.         Katsetos CD, Del Valle L, Legido A, deChadarévian JP, Geddes JF, and Mörk SJ. (2003).  On the neuroblastic nature of cerebellar Medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak.  Acta Neuropathologica (Berlin); 105 (1): 1-13

14987161.         Enam S, Sweet T, Amini S, Khalili K, and Del Valle L. (2004).  Evidence for involvement of transforming growth factor beta1 signaling pathway in activation of JC virus in human immunodeficiency virus 1-associated Progressive Multifocal Leukoencephalopathy.  Archives of Pathology and Laboratory Medicine; 128 (3): 282-291

15016869.          Del Valle L, Enam S, Lara C, Miklossy J, Khalili K, and Gordon J. (2004).  Primary central nervous system lymphoma expressing the human neurotropic polyomavirus, JC virus genome.  Journal of Virology; 78 (7): 3462-3469

15133494.         Shollar D, Del Valle L, Khalili K, and Gordon J. (2004).  JCV T-antigen interacts with the neurofibromatosis type 2 gene product in a transgenic mouse model of malignant peripheral nerve sheath tumor.  Oncogene; 23 (32): 5459-5467

15195141.         Rao G, Pedone CA, Del Valle L, Reiss K, Holland EC, and Fults DW. (2004).  Sonic hedgehog and Insulin-like Growth Factor signaling synergize to induce Medulloblastoma formation from nestin-expressing neural progenitors in mice.  Oncogene; 23 (36): 6156-6162

15965906.         Trojanek J, Ho T, Del Valle L, Wang JY, Darbinyan A, Nowicki M, Croul S, Skorski T, Khalili K, and Reiss K. (2006).  T-antigen from human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.  Journal of Cell Physiology; 206 (1): 35-46

16146764.          Del Valle L, and Piña-Oviedo S. (2005).  HIV disorders of the brain; pathology and pathogenesis.  Frontiers in Bioscience; 11: 718-732

16557392.         Piña-Oviedo S, Enam S, De León-Bojorque B, Cuesta-Mejías T, Ortiz-Hidalgo C, White M, Khalili K, and Del Valle L. (2006).  Glioblastoma multiforme with small cell neuronal-like component: association with human neurotropic JC virus.  Acta Neuropathologica (Berl); 111 (4): 388-396

16611822.         Aprea S, Del Valle L, Mameli G, Sawaya BE, Khalili K, and Peruzzi F. (2006).  Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal dependent-degradation of microtubule-associated protein 2 and neuronal damage.  Journal of Neuroscience; 26 (15): 4054-4062

17368705.         Darbinyan A, White MK, Akan S, Radhakrishnan S, Del Valle L, Amini S, and Khalili K. (2007). Alterations of DNA damage repair pathways resulting from JCV infection.  Virology; 364 (1): 73-86

17392168.         Piña-Oviedo S, Urbanska K, Radhakrishnan S, Sweet T, Reiss K, Khalili K, and Del Valle L. (2007). Effects of JC Virus Infection on Anti-Apoptotic Protein Survivin in Progressive Multifocal Leukoencephalopathy.  American Journal of Pathology; 170 (4): 1291-1304

17851187.         Woodruff-Pak DS, Agelan A, and Del Valle L. (2007).  A rabbit model of Alzheimer’s disease: valid at neuropathological, cognitive, and therapeutic levels.  Journal of Alzheimer’s Disease; 11 (3): 371-383

18688812.         Perez-Liz G, Del Valle L, Gentilella A, Croul S, and Khalili K. (2008). Detection of JC Virus DNA fragments but not proteins in normal brain tissue.  Annals of Neurology; 64 (4): 379-387

18786633.          Del Valle L, Schwartzman RJ, and Alexander G. (2009). Spinal cord histopathological alterations in a patient with longstanding Complex Regional Pain Syndrome.  Brain, Behavior, and Immunity; 23 (1): 85-91

19117011.         Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, Del Valle L, Khalili K and Reiss K. (2009). Estrogen Receptor b-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in Medulloblastoma.  Journal of Cellular Physiology; 219 (2): 392-401

19204000.         Deshmane SL, Mukerjee R, Fan S, Del Valle L, Michiels C, Sweet T, Rom I, Khalili K, Rappaport J, Amini S, and Sawaya BE. (2009). Activation of the oxidative stress pathway by HIV-1 Vpr leads to induction of Hypoxia Inducible Factor 1 alpha expression.  Journal of Biological Chemistry; 284 (17): 11,364-11,373

19335536.         Piña-Oviedo S, Del Valle L, Baquera-Heredia J, and Ortiz-Hidalgo C. (2009). Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineural cell origin.  Journal of the Peripheral Nervous System; 14 (1): 22-26

19360424.         Piña-Oviedo S, Khalili K, and Del Valle L. (2009). Hypoxia Inducible Factor-1 alpha activation of the JCV promoter: role in the pathogenesis of Progressive Multifocal Leukoencephalopathy.  Acta Neuropathologica (Berl); 118 (2): 235-247

19775291.         Riolfi M, Ferla R, Del Valle L, Piña-Oviedo S, Scolaro L, Micciolo R, Guidi M, Terrasi M, Cetto GL, and Surmacz E. (2010).  Leptin and its Receptor are overexpressed in Brain Tumors and correlate with the degree of malignancy.  Brain Pathology; 20 (2): 481-489

19834489.         Gualco E, Urbanska K, Perez-Liz G, Sweet T, Peruzzi F, Reiss K, and Del Valle L. (2010). IGF-1R dependent activation of Survivin is required for T-Antigen mediated protection from apoptosis and proliferation of neural progenitors.  Cell Death & Differentiation; 17 (3): 439-451

20181935.         Rom I, Rom S, Passiatore G, Pacifici M, Radhakrishnan S, Del Valle L, Piña-Oviedo S, Khalili K, Eletto D, and Peruzzi F. (2010). CCL8/MCP2 is a target for mir-146a in HIV-1 infected human microglial cells. FASEB Journal; 24 (7): 2292-2300

20190567.          Del Valle L, Piña-Oviedo S, Perez-Liz G, Augelli BJ, Azizi A, Khalili K, Gordon J, and Krynska B. (2010). Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics.  Cancer Biology & Therapy; 9 (4): 286-297

20336718.          Del Valle L, and Khalili K. (2010). Detection of JC virus proteins, T-Antigen and Agnoprotein in human tumor tissue arrays.  Journal of Medical Virology; 82 (5): 806-811

20631174.         Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, and Persidsky Y. (2010). Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: Implications for HIV-1 Encephalitis.  Journal of Neuroscience; 30 (28): 9454-9464

21088492.         Mukerjee R, Claudio PP, Chang JR, Del Valle L, and Sawaya BE. (2010). Transcriptional regulation of HIV-1 gene expression by p53.  Cell Cycle; 9 (22): 4569-4578

21115295.         Langford D, Baron D, Joy J, Del Valle L, and Shack J. (2011). Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation.  Psychoneuroendocrinology; 36 (5): 710-719

21561597.         Festa M, Del Valle L, Khalili K, Franco R, Scognamiglio G, Graziano V, De Laurenzi V, Turco MC, and Rosati A. (2011). BAG3 protein is overexpressed in human Glioblastoma and is a potential target for therapy.  American Journal of Pathology; 178 (6): 2504-2512

21745501.         Rom S, Pacifici M, Pasiatore G, Aprea S, Waligorska A, Del Valle L, and Peruzzi F. (2011). HIV-Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction. BBA: Molecular Cell Research; 1813 (10): 1836-1844

21816823.         Mukerjee R, Chang JR, Del Valle L, Bagashev A, Gayed MM, Lyde RB, Hawkins BJ, Brailoiu E, Cohen E, Power C, Azizi AS, Gelman BB, and Sawaya BE. (2011). Deregulation of microRNAs by HIV-1 Vpr leads to the development of neurocognitive disorders.  Journal of Biological Chemistry; 286 (40): 34,976-34,985

21956116.         Chang R, Mukerjee R, Del Valle L, Bagashev A, Hawkins BJ, and Sawaya BE. (2011).  HIV-1 Tat promotes neuronal dysfunction through disruption of microRNAs.  Journal of Biological Chemistry; 286 (47): 41,125-41,134

22454254.         Reiss K, Del Valle L, Lassak A, and Trojanek J. (2012). Nuclear IRS-1 and Cancer. Journal of Cellular Physiology; 227 (8): 2992-3000

23260029.         Dela Cruz FN, Giannitti F, Li L, Woods LW, Del Valle L, Delwart E, and Pesavento PA. (2013).  Novel Polyomavirus associated with Brain Tumors in Free-Ranging Raccoons, Western United States.  Emerging Infectious Diseases; 19 (1): 77-84

22926702.         Morrow K, Hernandez CP, Raber P, Del Valle L, Wilk AM, Majumdar S, Wyczechowska DD, Velasco C, Cole J, Reiss K, and Rodriguez PC. (2013). Anti-leukemic mechanisms of Pegylated Arginase in acute lymphoblastic T cell leukemia.  Leukemia; 27 (3): 569-577

23319800.         Guo G, Marrero L, Rodriguez P, Del Valle L, Ochoa A, and Cui Y. (2013). Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid-like stromal network.  Cancer Research; 73 (6): 1668-1675

23868972.         Struckoff AP, Rana MK, Kher SS, Burow ME, Hagan JL, Del Valle L, and Worthylake RA. (2013). PDZ-RhoGEF (PRG) is essential for CXCR4-driven Breast tumor cell motility through spatial regulation of RhoA.  Journal of Cell Science; 126 (19): 4514-4526

24830414.         Sierra RA, Thevenot P, Raber PL, Cui Y, Parsons C, Ochoa AC, Trillo-Tinoco J, Del Valle L, and Rodriguez PC. (2014). Rescue of Notch-1 signaling in antigen specific CD8+ T cells overcomes tumor-induced T cell suppression and enhances immunotherapy in cancer.  Cancer Immunology Research; 2 (8): 800-811

25229241.         Ripple M, Parker Struckhoff A, Trillo-Tinoco J, Li L, Margolin DA, McGoey R, and Del Valle L. (2014). Activation of c-Myc and Cyclin D1 by JCV T-Antigen and b-Catenin in Colon Cancer.  PLoS One; 9 (9): e106257

25238096.         Thevenot PT, Sierra RA, Raber PL, Al-Khami AA, Trillo-Tinoco J, Zarrei P, Ochoa AC, Cui Y, Del Valle L, and Rodriguez PC. (2014). The stress-response sensor Chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors.  Immunity; 41 (3): 389-401

26025381.         Hossain F, Al-Khami AA, Wyczechowska D, Hernandez C, Zheng L, Reiss K, Del Valle L, Trillo-Tinoco J, Rodriguez PC, and Ochoa AC. (2015). Inhibition of fatty acid oxidation modulates immunosuppressive functions of Myeloid-Derived Suppressor Cells and enhances cancer therapies.  Cancer Immunology Research; 3 (11): 1236-1247

26531163.         Dai L, Trillo-Tinoco J, Cao Y, Bonstaff KP, Doyle L, Del Valle L, Whitby D, Parsons CH, Reiss K, Zabaleta J, and Qin Z. (2015) Targeting HGF/c-MET induces cell cycle arrest, DNA damage and apoptosis for primary effusion lymphoma.  Blood; 126 (26): 2821-2831

26534959.         Kadri F, Pacifici M, Wilk A, Parker Struckhoff A, Del Valle L, Hauser KF, Knapp PE, Parsons C, Jeansonne D, Lassak A, and Peruzzi F. (2015). HIV-Tat inhibits SC35-mediated Tau exon 10 inclusion through upregulation of DYRK1A Kinase.  Journal of Biological Chemistry; 290 (52): 30,931-30,946

26639196.         Garai J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, and Zabaleta J. (2016). The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in the development of mucous metaplasia in mice.  Cancer Letters; 371 (1): 90-98

26859574.         Dai L, Qiao J, Nguyen D, Struckhoff AP, Doyle L, Bonstaff K, Del Valle L, Parsons C, Toole BP, Renne R, and Qin Z. (2016). Role of heme oxygenase-1 in the pathogenesis and tumorigenicity of Kaposi's sarcoma-associated herpesvirus.  Oncotarget; 7 (9): 10,459-10,471

27548814.         Maggi EC, Trillo-Tinoco J, Parker Struckhoff A, Vijayaraghavan J, Del Valle L, and Crabtree JS. (2016). Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype.  Oncogenesis; 5 (8): e257

27538487.         Bonsignore L, Passelli K, Pelzer C, Perroud M, Konrad A, Thurau M, Stürzl M, Dai L, Trillo-Tinoco J, Del Valle L, Qin Z, and Thome M. (2017). A role for MALT1 activity in Kaposi's sarcoma-associated herpesvirus latency and growth of primary effusion lymphoma.  Leukemia; 31 (3): 614-624

28456994.         Al-Khami AA, Ghonim MA, Del Valle L, Ibba SV, Zheng L, Pyakurel K, Okpechi SC, Garay J, Wyczechowska D, Sanchez-Pino MD, Rodriguez PC, Boulares AH, and Ochoa AC. (2017). Fueling the mechanisms of Asthma: increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.  Clinical & Experimental Allergy; 47 (9): 1170-1184

29123954.         Al-Khami AA, Zheng L, Del Valle L, Hossain F, Wyczechowska D, Zabaleta J, Sanchez MD, Dean MJ, Rodriguez PC, and Ochoa AC. (2017). Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells.  OncoImmunology; 6, (10): e1344804

29483302.         Lassak A, Dean M, Wyczechowska D, Wilk A, Marrero L, Trillo-Tinoco J, Boulares AH, Sarkaria JN, Del Valle L, Peruzzi F, and Ochoa A, and Reiss K. (2018). Molecular and structural traits of Insulin Receptor Substrate 1/LC3 nuclear structures and their role in autophagy control and tumor cell survival.  Molecular and Cellular Biology; 38 (10): e00608-17

29736315.         Dai L, Qiao J, Del Valle L, and Qin Z. (2018). KSHV co-infection regulates HPV16+ cervical cancer cells pathogenesis in vitro and in vivoAmerican Journal of Cancer Research; 8 (4): 708-714

29743595.         Dai L, Del Valle L, Miley W, Whitby D, Ochoa AC, Flemington EK, and Qin Z. (2018). Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s Sarcoma development.  Oncogene; 37 (33): 4534-4545

30564555.         Hossain F, Sorrentino C, Ucar DA, Peng Y, Matossian M, Wyczechowska D, Crabtree J, Zabaleta J, Morello S, Del Valle L, Burow M, Collins-Burow B, Pannuti A, Minter LM, Golde TE, Osborne BA and Miele L. (2018). Notch signaling regulates mitochondrial metabolism and NF-kB activity in triple-negative breast cancer cells via IKKa-dependent non-canonical pathways.  Frontiers in Oncology; 8: 575

31118047.         Sabol RA, Bowles AC, Côté A, Wise R, O’Donnell B, Matossian MD, Hossain FM, Burks HE, Del Valle L, Miele L, Collins-Burow BM, Burow ME, and Bunell BA. (2019). Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models.  Breast Cancer Research; 21 (1); 67

31078963.         Stalinska J, Zimolag E, Panovich NA, Zapata A, Lassak A, Rak M, Dean M, Ucar-Bilyeu DA, Wyczechowska D, Culicchia F, Marrero L, Del Valle L, Sarkaria JN, Peruzzi F, Jusic BS, and Reiss K. (2019). Chemically modified variants of Fenofibrate with high anti-Glioblastoma efficacy.  Translational Oncology; 12 (7): 895-907

31440465.         Del Valle L, and Piña-Oviedo S. (2019). Human Polyomavirus JCPyV and its role in Progressive Multifocal Leukoencephalopathy and Oncogenesis.  Frontiers in Oncology; 9: 711

32850332.         Hoang VT, Matossian MD, Ucar DA, Elliot S, La J, Wright MK, Burks HE, Perles A, Hossain F, King CT, Browning VE, Bursavich J, Fang F, Del Valle L, Bhatt AB, Cavanaugh JE, Flaherty PT, Anbalagan M, Rowan BG, Bratton MR, Nephew KP, Miele L, Collins-Burow BM, Martin EC, and Burow ME. (2020). ERK5 is required for tumor growth and maintenance through regulation of the extracellular matrix in Triple Negative Breast Cancer.  Frontiers in Oncology; 10: 1164

32518949.         Chen J, Goyal N, Dai L, Lin Z, Del Valle L, Zabaleta J, Liu J, Post S, Foroozesh M, and Qin Z. (2020). Developing new Ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated Lymphoma.  Blood; E-Pub June 9th 2020