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Current Ongoing Projects

1. Development of novel radiolabeled peptides for intraoperative tumor localization, scintigraphy, and in situ radiotherapy.
2. Development of in vitro models of human angiogenesis.
3. Alterations in gene expression during the transformation of human blood vessels from the quiescent to proliferative phenotype.
4. A clinical trial of a new somatostalin analog, SOM-230, for the treatment of Carcinoid Syndrome.
5. Development of lipophilic somatostatin analogs for
   in situ radiotherapy.
6. Development of hydrophilic somatostatin analogs for
   in situ radiotherapy.
7. Development of in vitro / in vitro modeling techniques for the administration of radiolabeled peptides.
8. A clinical trial of thalidomide as an anti-tumor agent in patients with carcinoid tumors.

Eugene A. Woltering, MD
Head of Surgical Research
ewolte@lsuhsc.edu

 

Patents

U.S. Patent Number 5,590,656 Issued January 7, 1997: "Application of Peptide/Cell Receptor Kinetics Utilizing Radiolabeled Somatostatin Congeners in the in situ, in vivo Detection and Differentiation of Neoplastic Tissue." Inventors: Thomas M. O'Dorisio, MD, M. Sue O'Dorisio, MD, PhD, Edward Martin, MD, and Eugene A. Woltering, MD

U.S. Patent Number 5,597,894 Issued January 28, 1997, "Multi-Tyrosinated Somatostatin Analogs." Inventors: David H. Coy, PhD, William A. Murphey, PhD, Eugene A. Woltering, MD, M. Sue O'Dorisio, MD, PhD, Thomas M. O'Dorisio, MD

U.S. Patent Number 6,180,082, Issued January 30, 2001: Method to Enhance Tissue Accumulation of Radiolabeled Compounds. Inventors: Eugene A. Woltering, MD and Gregory D. Espenan, M.S.

U.S. Patent Number 6,465,613, Issued October 15, 2002: Hydrophilic Somatostatin Analogs. Inventors: David H. Coy, PhD., William A. Murphy, PhD, Eugene Woltering, MD, Joseph A. Fuselier, MBA, and George J. Drouant.

 

Patent Applications

Application for U.S. Patent, "Three-Dimensional ex vivo Angiogenesis System". Applicants: Eugene A. Woltering, MD, and Seza Gulec, MD SN 09/866,296

Application for U.S. Patent, "Inhibition of Angiogenesis and Destruction of Angiogenic Vessels with Extracts of Noni Juice (Morinda Citrifolia)." Applicants: Eugene A. Woltering, MD, Conrad A. Hornick, PhD, Amy E. Myers SN 60/316,529

Application for U.S. Patent, "Use of Epothilones in Hyperarathyroidism. Applicant: Eugene A. Woltering, MD SN 60/418,592