School of Medicine

Selected Publications

Suresh Alahari, PhD, FAAS, Professor

SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach

Hassan Yousefi, Arash Poursheikhani, Zahra Bahmanpour, Mousa Vatanmakanian, Mohammad Taheri, Ladan Mashouri, Suresh K Alahari

Biomed Pharmacother. 2020 Oct;130:110548.

doi: 10.1016/j.biopha.2020.110548. Epub 2020 Jul 28.

Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance.

Yousefi H, Vatanmakanian M, Mahdiannasser M, Mashouri L, Alahari NV, Monjezi MR, Ilbeigi S, Alahari SK.

Oncogene. 2021 Jan 8. doi: 10.1038/s41388-020-01588-2. Online ahead of print.

PMID: 33420366 Review.

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action.

Yousefi H, Mashouri L, Okpechi SC, Alahari N, Alahari SK.

Biochem Pharmacol. 2021 Jan;183:114296. doi: 10.1016/j.bcp.2020.114296. Epub 2020 Oct 22.

PMID: 33191206 Free PMC article. Review.

Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers.

Dong S, Alahari SK.

Anticancer Drugs. 2020 Apr;31(4):359-367. doi: 10.1097/CAD.0000000000000880.

PMID: 31917699

Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance.

Yousefi H, Maheronnaghsh M, Molaei F, Mashouri L, Reza Aref A, Momeny M, Alahari SK.

Oncogene. 2020 Jan;39(5):953-974. doi: 10.1038/s41388-019-1040-y. Epub 2019 Oct 10.

PMID: 31601996 Review.

Knockout model reveals the role of Nischarin in mammary gland development, breast tumorigenesis and response to metformin treatment.

Dong S, Ruiz-Calderon B, Rathinam R, Eastlack S, Maziveyi M, Alahari SK.

Int J Cancer. 2020 May 1;146(9):2576-2587. doi: 10.1002/ijc.32690. Epub 2019 Oct 31.

PMID: 31525254

The Non-Coding RNA Journal Club: Highlights on Recent Papers-7.

Xiao H, Shiu PKT, Gabryleska M, Conn SJ, Dey A, Chakrabarti K, Regouc M, Pichler M, Ørom UAV, Santulli G, Nishiwada S, Goel A, Nagarajan V, Timmons L, Alahari SK, Laprovitera N, Ferracin M, Hu P, Jin H.

Noncoding RNA. 2019 Jun 11;5(2):40. doi: 10.3390/ncrna5020040.

PMID: 31212658 Free PMC article.

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance.

Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK.

Mol Cancer. 2019 Apr 2;18(1):75. doi: 10.1186/s12943-019-0991-5.

PMID: 30940145 Free PMC article. Review.

Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.

Maziveyi M, Dong S, Baranwal S, Mehrnezhad A, Rathinam R, Huckaba TM, Mercante DE, Park K, Alahari SK.

Cancer Res. 2019 May 1;79(9):2152-2166. doi: 10.1158/0008-5472.CAN-18-0842. Epub 2019 Jan 11.

PMID: 30635277 Free PMC article.

Development of insulin resistance in Nischarin mutant female mice.

Dong S, Blüher M, Zhang Y, Wu H, Alahari SK.

Int J Obes (Lond). 2019 May;43(5):1046-1057. doi: 10.1038/s41366-018-0241-8. Epub 2018 Dec 13.

PMID: 30546133

Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.

Eastlack SC, Dong S, Ivan C, Alahari SK.

Mol Cancer. 2018 Jul 16;17(1):100. doi: 10.1186/s12943-018-0851-8.

PMID: 30012170 Free PMC article.

Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.

Eastlack SC, Dong S, Mo YY, Alahari SK.

PLoS One. 2018 Jun 18;13(6):e0198945. doi: 10.1371/journal.pone.0198945. eCollection 2018.

PMID: 29912916 Free PMC article.

Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells.

Maziveyi M, Dong S, Baranwal S, Alahari SK.

Mol Cancer. 2018 Feb 7;17(1):21. doi: 10.1186/s12943-018-0764-6.

PMID: 29415725 Free PMC article.

Measurement of cell traction force with a thin film PDMS cantilever.

Holley MT, YekrangSafakar A, Maziveyi M, Alahari SK, Park K.

Biomed Microdevices. 2017 Nov 4;19(4):97. doi: 10.1007/s10544-017-0239-3.

PMID: 29103075

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications.

Serrano-Gomez SJ, Maziveyi M, Alahari SK.

Mol Cancer. 2016 Feb 24;15:18. doi: 10.1186/s12943-016-0502-x.

PMID: 26905733 Free PMC article. Review.

Breast Cancer Tumor Suppressors: A Special Emphasis on Novel Protein Nischarin.

Maziveyi M, Alahari SK.

Cancer Res. 2015 Oct 15;75(20):4252-9. doi: 10.1158/0008-5472.CAN-15-1395. Epub 2015 Sep 21.

PMID: 26392073 Review.

Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells.

Jain P, Baranwal S, Dong S, Struckhoff AP, Worthylake RA, Alahari SK.

J Biol Chem. 2013 May 31;288(22):15495-509. doi: 10.1074/jbc.M112.418103. Epub 2013 Apr 9.

PMID: 23572524 Free PMC article.

Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.

Kuijl C, Pilli M, Alahari SK, Janssen H, Khoo PS, Ervin KE, Calero M, Jonnalagadda S, Scheller RH, Neefjes J, Junutula JR.

EMBO J. 2013 Mar 6;32(5):713-27. doi: 10.1038/emboj.2013.10. Epub 2013 Feb 5.

PMID: 23386062 Free PMC article.

Prooncogenic factors miR-23b and miR-27b are regulated by Her2/Neu, EGF, and TNF-α in breast cancer.

Jin L, Wessely O, Marcusson EG, Ivan C, Calin GA, Alahari SK.

Cancer Res. 2013 May 1;73(9):2884-96. doi: 10.1158/0008-5472.CAN-12-2162. Epub 2013 Jan 21.

PMID: 23338610 Free PMC article.

Molecular characterization of the tumor-suppressive function of nischarin in breast cancer.

Baranwal S, Wang Y, Rathinam R, Lee J, Jin L, McGoey R, Pylayeva Y, Giancotti F, Blobe GC, Alahari SK.

J Natl Cancer Inst. 2011 Oct 19;103(20):1513-28. doi: 10.1093/jnci/djr350. Epub 2011 Sep 14.

PMID: 21917605 Free PMC article.

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis.

Wang Y, Shenouda S, Baranwal S, Rathinam R, Jain P, Bao L, Hazari S, Dash S, Alahari SK.

Mol Cancer. 2011 Jul 13;10:84. doi: 10.1186/1476-4598-10-84.

PMID: 21752283 Free PMC article.

ST14 (suppression of tumorigenicity 14) gene is a target for miR-27b, and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation.

Wang Y, Rathinam R, Walch A, Alahari SK.

J Biol Chem. 2009 Aug 21;284(34):23094-106. doi: 10.1074/jbc.M109.012617. Epub 2009 Jun 22.

PMID: 19546220 Free PMC article.

Molecular mechanisms controlling E-cadherin expression in breast cancer.

Baranwal S, Alahari SK.

Biochem Biophys Res Commun. 2009 Jun 19;384(1):6-11. doi: 10.1016/j.bbrc.2009.04.051. Epub 2009 Apr 18.

PMID: 19379710 Free PMC article. Review.

Nischarin inhibits LIM kinase to regulate cofilin phosphorylation and cell invasion.

Ding Y, Milosavljevic T, Alahari SK.

Mol Cell Biol. 2008 Jun;28(11):3742-56. doi: 10.1128/MCB.01832-07. Epub 2008 Mar 10.

PMID: 18332102 Free PMC article.

The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK.

Alahari SK, Reddig PJ, Juliano RL.

EMBO J. 2004 Jul 21;23(14):2777-88. doi: 10.1038/sj.emboj.7600291. Epub 2004 Jul 1.

PMID: 15229651 Free PMC article.

A membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin.

Alahari SK, Nasrallah H.

Biochem J. 2004 Jan 15;377(Pt 2):449-57. doi: 10.1042/BJ20030411.

PMID: 14535848 Free PMC article.

In a previous study [Alahari, Lee and Juliano (2000) J. Cell Biol. 151, 1141-1154], we have identified a novel protein, nischarin, that specifically interacts with the cytoplasmic tail of the alpha5 integrin subunit. ...

Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK.

Alahari SK.

Exp Cell Res. 2003 Aug 15;288(2):415-24. doi: 10.1016/s0014-4827(03)00233-7.

PMID: 12915132

Biological aspects of signal transduction by cell adhesion receptors.

Alahari SK, Reddig PJ, Juliano RL.

Int Rev Cytol. 2002;220:145-84. doi: 10.1016/s0074-7696(02)20005-4.

PMID: 12224548 Review.

Nischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migration.

Alahari SK, Lee JW, Juliano RL.

J Cell Biol. 2000 Dec 11;151(6):1141-54. doi: 10.1083/jcb.151.6.1141.

PMID: 11121431 Free PMC article.

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