Selected Publications

Maziveyi M, Dong S, Baranwal S, Mehrnezhad A, Rathinam R, Huckaba TM, Mercante DE, Park K, Alahari SK. Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and tumor growth. Cancer Res. 2019 Jan 11. pii: canres.0842.2018. doi: 10.1158/0008-5472.CAN-18-0842. [Epub ahead of print] PMID:30635277

Dong S, Blüher M, Zhang Y, Wu H, Alahari SK  Development of insulin resistance in Nischarin mutant female mice. Int J Obes (Lond). 2018 Dec 13. doi: 10.1038/s41366-018-0241-8. [Epub ahead of print] PMID: 30546133

Eastlack SC, Dong S, Mo YY, Alahari SK. Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer. PLoS One. 2018 Jun 18;13(6):e0198945. doi: 10.1371/journal.pone.0198945. eCollection 2018. PMID: 29912916

Maziveyi M, Dong S, Baranwal S, Alahari SK. Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells. Mol Cancer. 2018 Feb 7;17(1):21. doi: 10.1186/s12943-018-0764-6. PMID: 29415725

Holley MT, YekrangSafakar A, Maziveyi M, Alahari SK, Park K. Measurement of cell traction force with a thin film PDMS cantilever. Biomed Microdevices. 2017 Nov 4;19(4):97. doi: 10.1007/s10544-017-0239-3. PMID: 29103075

Dong S, Baranwal S, Garcia A, Serrano-Gomez SJ, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK. Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase. J Biol Chem. 2017 Oct 13;292(41):16833-16846. doi: 10.1074/jbc.M117.784256. Epub 2017 Aug 24. PMID: 28842496

Maziveyi M, Alahari SK. Cell matrix adhesions in cancer: The proteins that form the glue. Oncotarget. 2017 Jul 18;8(29):48471-48487. doi: 10.18632/oncotarget.17265. Review. PMID: 28476046

O'Bryan S, Dong S, Mathis JM, Alahari SK. The roles of oncogenic miRNAs and their therapeutic importance in breast cancer. Eur J Cancer. 2017 Feb;72:1-11. doi: 10.1016/j.ejca.2016.11.004. Epub 2016 Dec 18. Review. PMID:27997852

Serrano-Gomez SJ, Maziveyi M, Alahari SK. Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 2016 Feb 24;15:18. doi: 10.1186/s12943-016-0502-x. Review. PMID: 26905733

Maziveyi M, Alahari SK. Breast Cancer Tumor Suppressors: A Special Emphasis on Novel Protein Nischarin. Cancer Res. 2015 Oct 15;75(20):4252-9. doi: 10.1158/0008-5472.CAN-15-1395. Epub 2015 Sep 21. Review.

Eastlack, S., Dong, S., Ivan, C., Alahari, S.K., Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer (2018) Molecular Cancer, 17:100

Kim, H., Abd Elmageed, Z.Y., Ju, J., Naura, A. S., Abdel-Mageed A.B., Varughese, S., Paul, D., Alahari, S.K., Catling, A., Kim, J.G., and Boulares, H. Pdzk1 is a novel factor in breast cancer that is regulated by IGF-1R and promotes estrogen-mediated growth (2013) Molecular Medicine, (EPub ahead of print)

Jain, P., Baranwal, S., Dong, S., Struckoff, A., Worthylake, R., and Alahari, S.K.,  Integrin-binding protein Nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells (2013) Journal of Biological Chemistry, 31: 15495- 15509.

Kuijil, C*., Pilli, M*., Alahari, S.K.,*., (*equal contribution)., Janssen, H., Khoo, P., Ervin, K. E, Celero, M., Jonnalagadda, S., Scheller, RH., Neefjes, J., Junutula, J. Rac and Rab GTPases dual effector Nischarin facilitates survival of intracellular bacteria (2013) EMBO Journal , 32: 713-727.

Jin, L., Yu, Q., Wesseley, O., Marcusson, E., and Alahari, S.K., Her2 oncogene regulates the expression of miR-27b and 23b, which repress Nischarin to control tumor growth (2013) Cancer Research, 73: 2884-2896.

Alahari, S.K., Regulation of metastasis by microRNAs, a book chapter published in microRNA in cancer, Springer, 2012.

Jain, P., Worthylake, R. A., and Alahari, S.K.,. Quantitative analysis of random migration of cells using time-lapse video microscopy (2011). Journal of Visualized Experiments, 13: e3585.

Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer. Somesh Baranwal, Yanfang Wang, Rajamani Rathinam, Jason Lee, Lianjin Jin, Robin McGoey, Yuliya Pylayeva, Filippo Giancotti, Gerard C. Blobe and Alahari SK.JNCI J Natl Cancer Inst (2011) doi: 10.1093/jnci/djr350 First published online: September 14, 2011

Role of Rho GTPases and their regulators in cancer progression. Rathinam R, Berrier A, Alahari SK. Front Biosci. 2011 Jun 1;17:2561-71.PMID:21622195 [PubMed - in process] Related citations

Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis. Baranwal S, Alahari SK.Curr Drug Targets. 2011 Jul 1;12(8):1194-201.PMID:21561416[PubMed - in process]Related citations

Integrin subunits alpha5 and alpha6 regulate cell cycle by modulating the chk1 and Rb/E2F pathways to affect breast cancer metastasis. Yanfang Wang, Sylvia Shenouda, Somesh Baranwal, Rajamani Rathinam, Prachi Jain, Lili Bao, Siddhartha Hazari, Srikanta Dash and Alahari SK. Molecular Cancer, 2011 (IN PRESS).

Breast cancer stem cells: A new challenge for breast cancer treatment Jain P, Alahari SK Frontiers in Bioscience 16, 1824-1832, (1 January, 2011)

Integrin mediated function of Rab GTPases in cancer progression Subramani D and Alahari SKMolecular Cancer 2010, 9:312 (9 December 2010)

miRNA control of tumor cell invasion and metastasis.Baranwal S, Alahari SK. Int J Cancer. Oct 29. (2010)

Important role of integrins in the cancer biology. Rathinam R, Alahari SK.Cancer Metastasis Rev. Jan 30 .(2010)

Stromal cells and integrins: conforming to the needs of the tumor microenvironment. Alphonso A, Alahari SK.Neoplasia.Dec;11(12):1264-71. (2009)

MicroRNA function in cancer; Oncogene or a tumor suppressor. Shenouda, S.K. and Alahari S KCancer and Metastasis reviews. (In Press) (2009)

ST14 (suppression of tumorigenicity 14) gene is a target for miR-27b, and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation. Wang Y, Rathinam R, Walch A, Alahari SK. J Biol Chem. (2009)

Molecular mechanisms controlling E-cadherin expression in breast cancer Baranwal, S and Alahari S KBiochemical and Biophysical Research Communications. 384: 6-11B 2009 Jun 19;384(1):6-11. (2009)

Ding Y, Milosavljevic T, Alahari S K . Nischarin inhibits LIM Kinase to regulate Cofilin phosphorylation and Cell Invasion. Mol Cell Biol. Mar 10 (2008)

Alahari S K, Reddig, P., Juliano, R.L. The integrin binding protein Nischarin regulates cell migration by inhibiting PAK. EMBO J, 23: 2777-2788 (2004)

Juliano, R.L., Reddig, P.J., Alahari S K, Edin, M.L., Howe, A.K., and Aplin, A.E., Integrin Regulation of Cell Signaling and Motility.Biochem., Society Transactions 32: 443-446 (2004)

Alahari S K and H. Nasrallah : A Membrane proximal region of alpha-5 integrin is essential for its interaction with Nischarin. Biochemical Journal 15: 449-457 (2004)

Alahari S K: Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK. Exp. Cell Res. 288: 415-424 (2002)

Alahari SK, Reddig, P., Juliano, R.L. Biological aspects of signal transduction by cell adhesion receptors. Int. J. Cytology 220: 145-174 (2002)

Alahari S K,: Mapping of the gene for Nischarin, a novel integrin binding protein, to chromosome 3 by fluorescence in situ hybridization). Intl. J. Human Genetics 1: 271-274 (2001)

Alahari S K, Lee, J.L., and Juliano, R.L.: NISCHARIN, a novel protein that interacts with integrin alpha-5 subunit, and inhibits cell migration. J. Cell Biology 151: 1141-1154 (2000)

Methods for study of integrin regulation of receptor tyrosine kinase and G protein coupled receptor signaling to MAP kinases. Methods In Enzymology 333:151-163 (2001)

Shock, D.D., Naik, U.P., Brittain, J.E., Alahari, S K., Sondek, J., and Parise, L.V.: Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton Biochemical Journal 342: 729-735 (1999)

DeLong, R.K., Hoon, Y., Alahari S K, Fisher, M., Short, S.M., Kole, R and Juliano, R. L.: Novel cationic amphiphiles as delivery reagents for antisense oligonucleotides. Nucleic Acids Research 27:3334-3341.(1999)

Hughes, J. A., Astriab,A., Yoo, H., Alahari S K, Liang, E., Sergueev, D., Shaw, B. and Juliano, R.L.: In Vitro Transport and delivery of oligonucleotides. Methods in Enzymology 313:343-359. (1999)

Juliano, R.L., Alahari S K, Yoo, H., Kole, R., and Cho, M. Antisense Pharmacodynamics: Critical issues in the transport & delivery of antisense oligonucleotides. Pharmaceutical Research 16: 494-502.(1999)

Alahari S K, Delong, R., Fisher, M.H., Dean, N. M. Viliet, P and Juliano, R.L. Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression. J.Pharm.Exp. Therapeutics 286:419-428 (1998)

Howe.A., Aplin, A., Alahari S K, and Juliano, R.L.. Integrin signaling and cell growth Control.Current Opinion in Cell Biology 10: 220-231 (1998)

Aplin, A., Howe, A., Alahari, S K, and Juliano, R.L. Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, IG-CAMS and selectins. Pharmacological Reviews 50: 197-263 (1998)

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