School of Medicine


Hari K. Koul, PhD, Professor and Interim Head

Prostate-Derived ETS Factor (PDEF) Modulates Yes Associated Protein 1 (YAP1) in Prostate Cancer Cells: A Potential Cross-Talk between PDEF and Hippo Signaling.

Jaiswal PK, Mohajan S, Koul S, Wang F, Shi R, Koul HK.

Pharmaceuticals (Basel). 2019 Dec 10;12(4):181. doi: 10.3390/ph12040181.

PMID: 31835563 Free PMC article.


Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?

Jaiswal PK, Koul S, Palanisamy N, Koul HK.

Cancer Cell Int. 2019 Aug 31;19:224. doi: 10.1186/s12935-019-0947-2. eCollection 2019.

PMID: 31496918 Free PMC article.


Protocadherin 7 is overexpressed in castration resistant prostate cancer and promotes aberrant MEK and AKT signaling.

Shishodia G, Koul S, Koul HK.

Prostate. 2019 Nov;79(15):1739-1751. doi: 10.1002/pros.23898. Epub 2019 Aug 26.

PMID: 31449679


The TLK1-Nek1 axis promotes prostate cancer progression.

Singh V, Jaiswal PK, Ghosh I, Koul HK, Yu X, De Benedetti A.

Cancer Lett. 2019 Jul 1;453:131-141. doi: 10.1016/j.canlet.2019.03.041. Epub 2019 Mar 27.

PMID: 30928383 Free article.


Reactive oxygen species and cancer: A complex interaction.

Saikolappan S, Kumar B, Shishodia G, Koul S, Koul HK.

Cancer Lett. 2019 Jun 28;452:132-143. doi: 10.1016/j.canlet.2019.03.020. Epub 2019 Mar 21.

PMID: 30905813 Review.


Targeting the TLK1/NEK1 DDR axis with Thioridazine suppresses outgrowth of androgen independent prostate tumors.

Singh V, Jaiswal PK, Ghosh I, Koul HK, Yu X, De Benedetti A.

Int J Cancer. 2019 Aug 15;145(4):1055-1067. doi: 10.1002/ijc.32200. Epub 2019 Feb 25.

PMID: 30737777 Free PMC article.


Prostate-Derived Ets Factor (PDEF) Inhibits Metastasis by Inducing Epithelial/Luminal Phenotype in Prostate Cancer Cells.

Wang F, Koul S, Shanmugam PST, Dong Q, Koul HK.

Mol Cancer Res. 2018 Sep;16(9):1430-1440. doi: 10.1158/1541-7786.MCR-18-0010. Epub 2018 May 30.

PMID: 29848555 Free article.


Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.

Jaiswal PK, Koul S, Shanmugam PST, Koul HK.

Sci Rep. 2018 May 10;8(1):7459. doi: 10.1038/s41598-018-25798-7.

PMID: 29748619 Free PMC article.


Tetrandrine inhibits deregulated cell cycle in pancreatic cancer cells: Differential regulation of p21Cip1/Waf1, p27Kip1 and cyclin D1.

Singh K, Dong Q, TimiriShanmugam PS, Koul S, Koul HK.

Cancer Lett. 2018 Jul 1;425:164-173. doi: 10.1016/j.canlet.2018.03.042. Epub 2018 Mar 30.

PMID: 29605511


Tetrandrine (TET) Induces Death Receptors Apo Trail R1 (DR4) and Apo Trail R2 (DR5) and Sensitizes Prostate Cancer Cells to TRAIL-Induced Apoptosis.

Shishodia G, Koul S, Dong Q, Koul HK.

Mol Cancer Ther. 2018 Jun;17(6):1217-1228. doi: 10.1158/1535-7163.MCT-17-1157. Epub 2018 Mar 16.

PMID: 29549167 Free article.


Androgen receptor (AR) cistrome in prostate differentiation and cancer progression.

Wang F, Koul HK.

Am J Clin Exp Urol. 2017 Nov 9;5(3):18-24. eCollection 2017.

PMID: 29181434


Suresh Alahari, PhD, FAAS, Professor

SARS-CoV infection crosstalk with human host cell noncoding-RNA machinery: An in-silico approach

Hassan Yousefi, Arash Poursheikhani, Zahra Bahmanpour, Mousa Vatanmakanian, Mohammad Taheri, Ladan Mashouri, Suresh K Alahari

Biomed Pharmacother. 2020 Oct;130:110548.

doi: 10.1016/j.biopha.2020.110548. Epub 2020 Jul 28.


Understanding the role of integrins in breast cancer invasion, metastasis, angiogenesis, and drug resistance.

Yousefi H, Vatanmakanian M, Mahdiannasser M, Mashouri L, Alahari NV, Monjezi MR, Ilbeigi S, Alahari SK.

Oncogene. 2021 Jan 8. doi: 10.1038/s41388-020-01588-2. Online ahead of print.

PMID: 33420366 Review.


Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action.

Yousefi H, Mashouri L, Okpechi SC, Alahari N, Alahari SK.

Biochem Pharmacol. 2021 Jan;183:114296. doi: 10.1016/j.bcp.2020.114296. Epub 2020 Oct 22.

PMID: 33191206 Free PMC article. Review.


Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers.

Dong S, Alahari SK.

Anticancer Drugs. 2020 Apr;31(4):359-367. doi: 10.1097/CAD.0000000000000880.

PMID: 31917699


Long noncoding RNAs and exosomal lncRNAs: classification, and mechanisms in breast cancer metastasis and drug resistance.

Yousefi H, Maheronnaghsh M, Molaei F, Mashouri L, Reza Aref A, Momeny M, Alahari SK.

Oncogene. 2020 Jan;39(5):953-974. doi: 10.1038/s41388-019-1040-y. Epub 2019 Oct 10.

PMID: 31601996 Review.


Knockout model reveals the role of Nischarin in mammary gland development, breast tumorigenesis and response to metformin treatment.

Dong S, Ruiz-Calderon B, Rathinam R, Eastlack S, Maziveyi M, Alahari SK.

Int J Cancer. 2020 May 1;146(9):2576-2587. doi: 10.1002/ijc.32690. Epub 2019 Oct 31.

PMID: 31525254


The Non-Coding RNA Journal Club: Highlights on Recent Papers-7.

Xiao H, Shiu PKT, Gabryleska M, Conn SJ, Dey A, Chakrabarti K, Regouc M, Pichler M, Ørom UAV, Santulli G, Nishiwada S, Goel A, Nagarajan V, Timmons L, Alahari SK, Laprovitera N, Ferracin M, Hu P, Jin H.

Noncoding RNA. 2019 Jun 11;5(2):40. doi: 10.3390/ncrna5020040.

PMID: 31212658 Free PMC article.


Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance.

Mashouri L, Yousefi H, Aref AR, Ahadi AM, Molaei F, Alahari SK.

Mol Cancer. 2019 Apr 2;18(1):75. doi: 10.1186/s12943-019-0991-5.

PMID: 30940145 Free PMC article. Review.


Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth.

Maziveyi M, Dong S, Baranwal S, Mehrnezhad A, Rathinam R, Huckaba TM, Mercante DE, Park K, Alahari SK.

Cancer Res. 2019 May 1;79(9):2152-2166. doi: 10.1158/0008-5472.CAN-18-0842. Epub 2019 Jan 11.

PMID: 30635277 Free PMC article.


Development of insulin resistance in Nischarin mutant female mice.

Dong S, Blüher M, Zhang Y, Wu H, Alahari SK.

Int J Obes (Lond). 2019 May;43(5):1046-1057. doi: 10.1038/s41366-018-0241-8. Epub 2018 Dec 13.

PMID: 30546133


Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer.

Eastlack SC, Dong S, Ivan C, Alahari SK.

Mol Cancer. 2018 Jul 16;17(1):100. doi: 10.1186/s12943-018-0851-8.

PMID: 30012170 Free PMC article.


Expression of long noncoding RNA MALAT1 correlates with increased levels of Nischarin and inhibits oncogenic cell functions in breast cancer.

Eastlack SC, Dong S, Mo YY, Alahari SK.

PLoS One. 2018 Jun 18;13(6):e0198945. doi: 10.1371/journal.pone.0198945. eCollection 2018.

PMID: 29912916 Free PMC article.


Nischarin regulates focal adhesion and Invadopodia formation in breast cancer cells.

Maziveyi M, Dong S, Baranwal S, Alahari SK.

Mol Cancer. 2018 Feb 7;17(1):21. doi: 10.1186/s12943-018-0764-6.

PMID: 29415725 Free PMC article.


Measurement of cell traction force with a thin film PDMS cantilever.

Holley MT, YekrangSafakar A, Maziveyi M, Alahari SK, Park K.

Biomed Microdevices. 2017 Nov 4;19(4):97. doi: 10.1007/s10544-017-0239-3.

PMID: 29103075


Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.

Dong S, Baranwal S, Garcia A, Serrano-Gomez SJ, Eastlack S, Iwakuma T, Mercante D, Mauvais-Jarvis F, Alahari SK.

J Biol Chem. 2017 Oct 13;292(41):16833-16846. doi: 10.1074/jbc.M117.784256. Epub 2017 Aug 24.

PMID: 28842496


Shymal Desai, PhD, Associate Professor

SUMOylation of mitofusins: a potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressors.

Kim C, Juncker M, Reed R, Haas A, Guidry J, Matunis M, Yang, WC, Schwartzenburg J, *Desai SD.

BBA-Molecular Biology of Disease 2021; DOI# 10.1016/j.bbadis.2021.166104


ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in ataxia telangiectasia cells.

Juncker M, Kim C, Reed R, Haas A, Schwartzenburg J, *Desai SD.

BBA-Molecular Biology of Disease 2021; DOI# 10.1016/j.bbadis.2021.166102


Evidence for the Deregulation of Protein Turnover Pathways in Atm-Deficient Mouse Cerebellum: An Organotypic Study.

Kim CD, Reed RE, Juncker MA, Fang Z, Desai SD.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):578-584. doi: 10.1093/jnen/nlx038.

PMID: 28535250


ISG15: A double edged sword in cancer.

Desai SD.

Oncoimmunology. 2015 Jun 1;4(12):e1052935. doi: 10.1080/2162402X.2015.1052935. eCollection 2015 Dec.


Jessie Guidry, Instructor

Transcriptome analysis reveals sexual disparities in gene expression in rat brain microvessels.

Chandra PK, Cikic S, Baddoo M, Rutkai I, Guidry JJ, Flemington EK, Katakam PVG, Busija DW.

Journal of Cerebral Blood Flow & Metabolism . (2021) March 9th, 2021.

DOI: 10.1177/0271678X21999553


Disruption of the putative ribosome-binding motif of a scaffold protein impairs cytochrome c oxidase subunit expression in Leishmania major.

D Cardenas, C Sylvester, B Cao, C Nation, J Pizzaro, H Lu, J Guidry, B Kelly

mSphere . 2019 Mar 6;4(2).

PMID: 30842271


Mobilization of Iron Stored in Bacterioferritin Is Required for Metabolic Homeostasis in Pseudomonas aeruginosa.

Punchi Hewage A, Fontenot L, Guidry J, Weldeghiorghis T, Mehta A, Donnarumma F, Rivera M.

Pathogens. (2020) 9, 980. November. Doi:10.3390/pathogens9120980.


Oxidation of Cytochrome 605 Is the Rate-Limiting Step when Ferrimicrobium acidiphilum Respires Aerobically on Soluble Iron.

Blake RC 2nd, Guidry JJ, Anthony MD, Ban B, Smith KA, Walton NN, Painter RG.

Appl Environ Microbiol. 2020 Oct 28;86(22):e01906-20. doi: 10.1128/AEM.01906-20. Print 2020 Oct 28.

PMID: 32917753


Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights.

Harman JC, Guidry JJ, Gidday JM.

Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):15. doi: 10.1167/iovs.61.11.15.

PMID: 32910134 Free PMC article.


The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein.

Ogunlade B, Guidry JJ, Mukerjee S, Sriramula S, Lazartigues E, Filipeanu CM.

Cell Mol Neurobiol. 2020 Aug 31:1-9. doi: 10.1007/s10571-020-00951-x. Online ahead of print.

PMID: 32865675 Free PMC article.


A comprehensive analysis of sialolith proteins and the clinical implications.

Busso CS, Guidry JJ, Gonzalez JJ, Zorba V, Son LS, Winsauer PJ, Walvekar RR.

Clin Proteomics. 2020 Mar 31;17:12. doi: 10.1186/s12014-020-09275-w. eCollection 2020.

PMID: 32265614 Free PMC article.


Sexual differences in mitochondrial and related proteins in rat cerebral microvessels: A proteomic approach.

Cikic S, Chandra PK, Harman JC, Rutkai I, Katakam PV, Guidry JJ, Gidday JM, Busija DW.

J Cereb Blood Flow Metab. 2020 Apr 2:271678X20915127. doi: 10.1177/0271678X20915127. Online ahead of print.

PMID: 32241204


Differential Protein Expression Profiles of Bronchoalveolar Lavage Fluid Following Lipopolysaccharide-Induced Direct and Indirect Lung Injury in Mice.

Yue X, Guidry JJ.

Int J Mol Sci. 2019 Jul 11;20(14):3401. doi: 10.3390/ijms20143401.

PMID: 31373289 Free PMC article.


Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation.

Pascale CL, Martinez AN, Carr C, Sawyer DM, Ribeiro-Alves M, Chen M, O'Donnell DB, Guidry JJ, Amenta PS, Dumont AS.

J Cereb Blood Flow Metab. 2020 May;40(5):1077-1089. doi: 10.1177/0271678X19858888. Epub 2019 Jun 20.

PMID: 31220996


5'-Iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth.

Chen C, Breslin MB, Guidry JJ, Lan MS.

J Biol Chem. 2019 Apr 5;294(14):5456-5465. doi: 10.1074/jbc.RA118.006761. Epub 2019 Feb 12.

PMID: 30755485 Free PMC article.


Comprehensive characterization of the adult ND4 Swiss Webster mouse retina: Using discovery-based mass spectrometry to decipher the total proteome and phosphoproteome.

Harman JC, Guidry JJ, Gidday JM.

Mol Vis. 2018 Dec 31;24:875-889. eCollection 2018.

PMID: 30713425 Free PMC article.


Arthur L. Haas, PhD, Professor

ISG15 attenuates post-translational modifications of mitofusins and congression of damaged mitochondria in ataxia telagiectasia cells.

Juncker, M., Kim, C., Reed, R., Haas, A.L., Schwartzenburg, J., Desai, S.D.

Biochem. Biophys. Acta-Mol. Basis Disease 1867, 166101 (2021)


SUMOylation of mitofusins: a potential mechanism for perinuclear mitochondrial congression in cells treated with mitochondrial stressors.

Kim, C., Juncker, M., Reed, R., Haas, A., Guidry, J., Matunis, M., Yang, W.C., Schwartzenburg, J., and Desai, S.

Biochem. Biophys. Acta-Mol. Basis Disease 1867, 166104 (2021)


Oligomerization of the HECT ubiquitin ligase NEDD4-2/NEDD4L is essential for polyubiquitin chain assembly.

Todaro DR, Augustus-Wallace AC, Klein JM, Haas AL.

J Biol Chem. 2018 Nov 23;293(47):18192-18206. doi: 10.1074/jbc.RA118.003716. Epub 2018 Oct 4.

PMID: 30287686


The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.

Todaro DR, Augustus-Wallace AC, Klein JM, Haas AL.

J Biol Chem. 2017 Nov 24;292(47):19521-19536. doi: 10.1074/jbc.M117.817882. Epub 2017 Sep 28.

PMID: 28972136 Free PMC article.


In silico modeling of the cryptic E2∼ubiquitin-binding site of E6-associated protein (E6AP)/UBE3A reveals the mechanism of polyubiquitin chain assembly.

Ronchi VP, Kim ED, Summa CM, Klein JM, Haas AL.

J Biol Chem. 2017 Nov 3;292(44):18006-18023. doi: 10.1074/jbc.M117.813477. Epub 2017 Sep 18.

PMID: 28924046


Sunyoung Kim, PhD, Professor

Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly.

Kim CD, Kim ED, Liu L, Buckley RS, Parameswaran S, Kim S, Wojcik EJ.

Sci Rep. 2019 Dec 27;9(1):19900. doi: 10.1038/s41598-019-56173-9.

PMID: 31882607 Free PMC article.


Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.

Heath M, Buckley R, Gerber Z, Davis P, Linneman L, Gong Q, Barkemeyer B, Fang Z, Good M, Penn D, Kim S.

JAMA Netw Open. 2019 Nov 1;2(11):e1914996. doi: 10.1001/jamanetworkopen.2019.14996.

PMID: 31702803


Rinku Majumder, PhD, Associate Professor

Protein S: function, regulation, and clinical perspectives.

Majumder R, Nguyen T

Curr Opin Hematol 2021 Jul 1. doi: 10.1097/MOH.0000000000000663.

Online ahead of print.PMID: 34224431


Phosphatidylserine and Phosphatidylethanolamine Regulate the Structure and Function of FVIIa and Its Interaction with Soluble Tissue Factor

Tanusree Sengupta, Tilen Koklic, Barry R Lentz and Rinku Majumder,

Bioscience Reports (in press)  DOI: 10.1042/BSR20204077


Modulation of protein S and growth arrest specific 6 protein signaling inhibits pancreatic cancer cell survival and proliferation.

Pilli VS, Datta A, Dorsey A, Liu B, Majumder R.

Oncol Rep. 2020 Oct;44(4):1322-1332. doi: 10.3892/or.2020.7689. Epub 2020 Jul 15.

PMID: 32945517 Free PMC article.


COVID-19: a probable role of the anticoagulant Protein S in managing COVID-19-associated coagulopathy.

Chatterjee S, Sengupta T, Majumder S, Majumder R.

Aging (Albany NY). 2020 Aug 19;12(16):15954-15961. doi: 10.18632/aging.103869. Epub 2020 Aug 19.

PMID: 32826388 Free PMC article.


Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis.

Holly SP, Gera N, Wang P, Wilson A, Guan Z, Lin L, Cooley B, Alfar HR, Patil RG, Piatt R, Leisner TM, Bergmeier W, Majumder R, Parise LV.

Blood Adv. 2019 Nov 26;3(22):3818-3828. doi: 10.1182/bloodadvances.2018030767.

PMID: 31770438 Free PMC article.


Protein S in preventing thrombosis.

Fricke DR, Chatterjee S, Majumder R.

Aging (Albany NY). 2019 Jan 25;11(3):847-848. doi: 10.18632/aging.101798.

PMID: 30683834


Padua FIXa resistance to Protein S and a potential therapy for hyperactive FIXa.

Plautz WE, Chattopadhyay R, Goldfeld EI, Samelson-Jones BJ, Pilli VS, Campello E, Datta A, Arruda VR, Simioni P, Majumder R.

Thromb Res. 2018 Oct;170:133-141. doi: 10.1016/j.thromres.2018.08.018. Epub 2018 Aug 27.

PMID: 30189336


Protein S: a Multifunctional Anticoagulant.

Dorsey A, Pilli VS, Fried H, Majumder R.

Biomed Res Clin Pract. 2017 Dec;2(5):10.15761/BRCP.1000151. doi: 10.15761/BRCP.1000151. Epub 2017 Nov 20.

PMID: 30148214 Free PMC article. No abstract available.


Hypoxia downregulates protein S expression.

Pilli VS, Datta A, Afreen S, Catalano D, Szabo G, Majumder R.

Blood. 2018 Jul 26;132(4):452-455. doi: 10.1182/blood-2018-04-841585. Epub 2018 May 21.

PMID: 29784640 Free PMC article.


Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis.

Plautz WE, Sekhar Pilli VS, Cooley BC, Chattopadhyay R, Westmark PR, Getz T, Paul D, Bergmeier W, Sheehan JP, Majumder R.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):816-828. doi: 10.1161/ATVBAHA.117.310588. Epub 2018 Feb 1.

PMID: 29419409 Free PMC article.


Edward Wojcik, PhD, Associate Professor

Small molecule allosteric uncoupling of microtubule depolymerase activity from motility in human Kinesin-5 during mitotic spindle assembly.

Kim CD, Kim ED, Liu L, Buckley RS, Parameswaran S, Kim S, Wojcik EJ.

Sci Rep. 2019 Dec 27;9(1):19900. doi: 10.1038/s41598-019-56173-9.

PMID: 31882607 Free PMC article.


Disruption of the Putative Ribosome-Binding Motif of a Scaffold Protein Impairs Cytochrome c Oxidase Subunit Expression in Leishmania major.

Cardenas D, Sylvester C, Cao B, Nation CS, Pizarro JC, Lu H, Guidry J, Wojcik EJ, Kelly BL.

mSphere. 2019 Mar 6;4(2):e00644-18. doi: 10.1128/mSphere.00644-18.

PMID: 30842271 Free PMC article.


Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia.

Jennings S, Chenevert M, Liu L, Mottamal M, Wojcik EJ, Huckaba TM.

PLoS One. 2017 Jul 5;12(7):e0180353. doi: 10.1371/journal.pone.0180353. eCollection 2017.

PMID: 28678816


David Worthylake, PhD, Associate Professor

Ubiquitination of the scaffold protein IQGAP1 diminishes its interaction with and activation of the Rho GTPase CDC42.

Gorisse L, Li Z, Wagner CD, Worthylake DK, Zappacosta F, Hedman AC, Annan RS, Sacks DB.

J Biol Chem. 2020 Apr 10;295(15):4822-4835. doi: 10.1074/jbc.RA119.011491. Epub 2020 Feb 24.

PMID: 32094223


Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope.

Sadraeian M, Guimarães FEG, Araújo APU, Worthylake DK, LeCour LJ, Pincus SH.

Sci Rep. 2017 Aug 8;7(1):7579. doi: 10.1038/s41598-017-08037-3.

PMID: 28790381 Free PMC article.


Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160.

Pincus SH, Song K, Maresh GA, Frank A, Worthylake D, Chung HK, Polacino P, Hamer DH, Coyne CP, Rosenblum MG, Marks JW, Chen G, Weiss D, Ghetie V, Vitetta ES, Robinson JE, Hu SL.

J Virol. 2017 Jan 18;91(3):e01360-16. doi: 10.1128/JVI.01360-16. Print 2017 Feb 1.

PMID: 27795412 Free PMC article.