Gregory Bagby, PhD

Emeritus Professor of Physiology


PhD - 1976
Washington State University

Research Interests

Interaction between chronic alcohol consumption on the progression of simian immunodeficiency virus infection.
Impact of infection and alcohol on stem cell biology and the hematopoietic response.
Alcohol immunosuppression of cytokine production and action, and neutrophil migration.
Role of cytokines in pulmonary and systemic host defense. Selected cytokine transcytosis from the intrapulmonary compartment to the blood: Mechanism and Consequence

Selected Publications

Simon L, Lecapitaine N, Berner P, Vande Stouwe C, Mussell JC, Allerton TD, Primeaux SD, Dufour J, Nelson S, Bagby GJ, Cefalu W, Molina PE.Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. Am J Physiol Regul Integr Comp Physiol. 2014 Mar 26. [Epub ahead of print]

Melvan JN, Mooney J, Bagby GJ, Hunt JP, Batson R, Greiffenstein P. Drug and alcohol use complicate traumatic peripheral vascular injury. J Trauma Acute Care Surg. 2013 Aug;75(2):258-65. doi: 10.1097/TA.0b013e31829246e1.

Pahar B, Amedee AM, Thomas J, Dufour JP, Zhang P, Nelson S, Veazey RS, Bagby GJ.Effects of alcohol consumption on antigen-specific cellular and humoral immune responses to SIV in rhesus macaques. J Acquir Immune Defic Syndr. 2013 Dec 1;64(4):332-41. doi: 10.1097/QAI.0b013e31829f6dca.

Nelson S, Happel KI, Zhang P, Myers L, Dufour JP, Bagby GJ. Effect of bacterial pneumonia on lung simian immunodeficiency virus (SIV) replication in alcohol consuming SIV-infected rhesus macaques. Alcohol Clin Exp Res. 2013 Jun;37(6):969-77. doi: 10.1111/acer.12070. Epub 2013 Feb 15.

Melvan JN, Siggins RW, Stanford WL, Porretta C, Nelson S, Bagby GJ, Zhang P. Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem cell antigen-1/ERK pathway. J Immunol. 2012 Feb 15;188(4):1961-9. doi: 10.4049/jimmunol.1102395. Epub 2012 Jan 11.

LeCapitaine NJ, Wang ZQ, Dufour JP, Potter BJ, Bagby GJ, Nelson S, Cefalu WT, Molina PE. Disrupted anabolic and catabolic processes may contribute to alcohol-accentuated SAIDS-associated wasting. J Infect Dis. 2011 Oct 15;204(8):1246-55. doi: 10.1093/infdis/jir508.

Zamjahn JB, Quinton LJ, Mack JC, Frevert CW, Nelson S, Bagby GJ.Differential flux of macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant from the lung after intrapulmonary delivery.Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L568-74. doi: 10.1152/ajplung.00340.2010. Epub 2011 Jul 8.

Melvan JN, Siggins RW, Bagby GJ, Stanford WL, Welsh DA, Nelson S, Zhang P.  Suppression of the stem cell antigen-1 response and granulocyte lineage expansion by alcohol during septicemia. Crit Care Med. 2011 Sep;39(9):2121-30. doi: 10.1097/CCM.0b013e31821e89dc.

Huff NK, Spencer ND, Gimble JM, Bagby GJ, Nelson S, Lopez MJ. Impaired expansion and multipotentiality of adult stromal cells in a rat chronic alcohol abuse model. Alcohol. 2011 Jun;45(4):393-402. doi: 10.1016/j.alcohol.2010.12.005. Epub 2011 Mar 4.

Raasch CE, Zhang P, Siggins RW III, LaMotte LR, Nelson S, Bagby GJ, Acute alcohol intoxication impairs the hematopoietic precursor cell response to pneumococcal pneumonia, Alcohol Clin Exp Res 2010 Dec;34(12):2035-43. doi: 10.1111/j.1530-0277.2010.01291.x.

Thomas JS, Lacour N, Kozlowski PA, Nelson S, Bagby GJ, Amedee AM.Characterization of SIV in the oral cavity and in vitro inhibition of SIV by rhesus macaque saliva. AIDS Res Hum Retroviruses. 2010 Aug;26(8):901-11. doi: 10.1089/aid.2009.0235.

Siggins RW, Melvan JN, Welsh DA, Bagby GJ, Nelson S, Zhang P.Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling. J Immunol. 2011 Apr 1;186(7):4306-13. doi: 10.4049/jimmunol.1002885. Epub 2011 Feb 28.

Gomez M, Raju SV, Viswanathan A, Painter RG, Bonvillain R, Byrne P, Nguyen DH, Bagby GJ, Kolls JK, Nelson S, Wang G, Ethanol unregulates glucocorticoid-induced leucine zipper expression and modulates cellular inflammatory responses in lung epithelial cells, J Immunol 39:1597-1607, 2010.

Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S, The systemic and pulmonary lipopolysaccharide binding protein response to intratracheal lipopolysaccharide., Shock 31:212-217, 2009.

Siggins, RW, Bagby GJ, Molina P, Dufour J, Nelson S and Zhang P, Alcohol exposure impairs myeloid dendritic cell function in rhesus macaques, Alcohol Clin Exp Res 33:1524-1531, 2009.

Reutershan J, Harry B, Chang D, Bagby GJ, Ley K., DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines., Eur J Immunol 39:1597-1607, 2009.

Zhang P, Welsh DA, Siggins RW 2nd, Bagby GJ, Raasch CE, Happel KI, Nelson S., Acute alcohol intoxication inhibits the lineage-c-kit+Sca-1+ cell response to Escherichia coli bacteremia, J Immunol 182:1568-76, 2009.

Walker JE Jr, Odden AR, Jeyaseelan S, Bagby GJ, Nelson S, Happel KI, Ethanol exposure impairs LPS-induced pulmonary LIX expression: alveolar epithelial cell dysfunction as a consequence of acute intoxication, Alcohol Clin Exp Res 33:357-365, 2009.

Molina PE, Lang CH, McNurlan M, Bagby GJ, Nelson S., Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting., Alcohol Clin Exp Res 32:138-147, 2008.

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