MD - 1995 Beijing Medical University
PhD - 2000 Anatomy and Cell Biology, University of Iowa
2001–2003 Postdoctoral Associate, Department of Biology, Massachusetts Institute of Technology (Advisor: Dr. Robert D. Rosenberg)
2003–2005 Postdoctoral Fellow, Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison (Advisor: Dr. Alan C. Rapraeger)
2006–2008 Postdoctoral Fellow, Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center (Advisor: Dr. Joseph A. Lasky)
Research in my laboratory focuses on understanding the pathophysiology and molecular mechanisms of lung diseases. We have long-standing interests in the role of heparan sulfate 6-O-endosulfatases (the Sulfs) in the pathogenesis of idiopathic pulmonary fibrosis and acute lung injury. In addition, in collaboration with Drs. Jason Gardner (Physiology) and Eric Lazartigues (Pharmacology), we are interested in examining the effects of chronic nicotine inhalation on the development of cardiopulmonary diseases with a focus on the renin-angiotensin system. Current active projects include: understand the function of the Sulfs in lung injury, inflammation, repair and regeneration; explore the therapeutic values of recombinant Sulfs and heparin analogs in the treatment of lung injury, inflammation and fibrosis; examine the impact of chronic nicotine inhalation on the development of lung diseases and its associated molecular mechanisms.
Area of Expertise: Pulmonary Physiology
DHY 3202 - General and Oral Physiology
INTER 132/PHTH 7122 - Biological Systems
HLSC 3410/HLSC 6410 – Nursing Pathophysiology
HLSC 2410 – Nursing Human Physiology
DHY 3202 - General and Oral Physiology
DENT 1115 - Human Physiology
Oakes JM, Fuchs RM, Gardner JD, Lazartigues E, Yue X. (2018) Nicotine and the Renin-Angiotensin System. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 8. doi: 10.1152/ajpregu.00099.2018. [Epub ahead of print] PMID: 30088946.
Yue X*, Basting TM, Flanagan TW, Xu J, Lobell TD, Gilpin NW, Gardner JD, and Lazartigues E. (2018) Nicotine Downregulates the Compensatory Angiotensin-Converting Enzyme 2/Angiotensin Type 2 Receptor of the Renin–Angiotensin System. Ann Am Thorac Soc.15(S2):S126-S127. PMID: 29676623 (*Corresponding Author)
Yue X. (2017) Epithelial deletion of Sulf2 exacerbates bleomycin-induced lung injury, inflammation and mortality. Am J Respir Cell Mol Biol. 57(5):560-569. PMID: 2865777; PMCID: PMC5705905
Chodavarapu H, Chhabra KH, Xia H, Shenoy V, Yue X, Lazartigues E. (2016) High-fat diet-induced glucose dysregulation is independent of changes in Islet ACE2 in mice. Am J Physiol Regul Integr Comp Physiol. 311(6):R1223-R1233. PMID: 27806985
Auduong L, Hogan EA, YueX. (2015) Role of Sulf2 in Alveolar Epithelial Injury and Repair. Ann Am Thorac Soc. 12(S1):S73-S74. PMID: 25830846
Lu J, Auduong L, White ES, Yue X. (2014) Upregulation of Heparan Sulfate 6-O-Sulfation in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 50(1):106-14. PMID: 23962103
Yue X*, Lu J, Auduong L, Sides MD, Lasky JA. (2013) Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology 23:709-19. (*Corresponding Author)
Yue X, Shan B and Lasky JA. (2010) TGF-b: Titan of Lung Fibrogenesis. Current Enzyme Inhibition 6(2):67-77.
Yue X, Li X, Nguyen HT, Levy DR, Sullivan DE, and Lasky JA. (2008) TGF-β1 induces heparan sulfate 6-O-endosulfatase 1 expression in vitro and in vivo. J Biol Chem. 283(29):20397-407. PMID: 18503048.
Feng Y, Yue X, Xia H, Bindom SM, Hickman PJ, Filipeanu CM, Wu G and Lazartigues E. (2008) Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation. Circ Res. 102(6):729-36. PMID: 18258853.