Lan Michael

Michael S. Lan, PhD

Professor of Pediatrics and Genetics
Louisiana State University Health Sciences Center, New Orleans

Children’s Hospital Professorship of Pediatric Research

mlan@lsuhsc.edu

Degrees

1976 - B.S. in Chemistry, SooChow University, Taiwan, R.O.C.
​1980 - M.S. in Molecular Biology, Tsing Hua University, Taiwan, R.O.C.
1986 - Ph.D. in Microbiology and Immunology, Duke University, Durham, NC USA

Research Interests

- Transcription factors in neuroendocrine differentiation
- Insulin gene regulation and tolerance induction via INS-VNTR and AIRE in human thymic epithelial cells
- Role of islet transcription factor in endocrine pancreas development
- Mechanisms of neuroendocrine transformation and therapeutic study

Selected Publications

Zhang, T., Chen, C., Breslin, M.B., Song, K., and Lan, M.S.: Extra-nuclear activity of INSM1 transcription factor enhances insulin receptor signaling pathway and Nkx6.1 expression through RACK1 interaction. Cell Signal., 26: 740-747, 2014. PMC3927318

 

Lan, M.S., Chen, C., Saunee, N.A., Zhang, T., and Breslin, M.B.: Expression of biologically active TAT-fused recombinant islet transcription factors. Life Sciences, 114: 45-50, 2014.

 

Chen, C., Breslin, M.B., and Lan, M.S.: INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma. Oncotarget, 6: 36700-36712, 2015. PMC4742205

 

Tseng, A.W., Akerstrom, V., Chen, C., Breslin, M.B., and Lan, M.S.: Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase. Int. J. Oncol., 48: 173-180, 2016.

 

Sparks, A.E., Chen, C., Breslin, M.B., and Lan, M.S.: Functional domains of autoimmune regulator, AIRE, modulate INS-VNTR transcription in human thymic epithelial cells. J. Biol. Chem., 291: 11313-11322 2016.

 

Tseng, A.W., Chen, C., Breslin, M.B., and Lan, M.S.: Tumor-specific promoter driven therapy for insulinoma. Cell. Oncol., 39: 279-286, 2016.

 

Chen, C., Breslin, M.B., and Lan, M.S.: Ectopic expression of a small cell lung carcinoma transcription factor, INSM1, impairs alveologenesis in lung development. BMC Pulmonary Medicine, 16: 49-58, 2016. PMC4830008

Additional Info Publications at PubMed