School of Medicine

Older News from the Lazartigues lab:

2020

• Ms Tamara Morris has been accepted into the LSUHSC-NO Interdisciplinary graduate program. (3/2020)
• From our collaboration with Drs. Yue and Gardner (LSUHSC-NO Physiology), Dr. Jiaxi Xu and Ms. Tamara Morris manuscript entitled "Effects of chronic nicotine inhalation on systemic and pulmonary blood pressure and right ventricular remodeling in mice" was accepted for publication in Hypertension. See LSU website-related release here. (2/2020)
• Dr. Mona Elgazzaz was selected to receive the Mead Johnson Research Award from the APS Endocrinology and Metabolism section. (1/2020)
• Dr. Lazartigues and his colleague Dr. Catalin Filipeanu (Howard University) were awarded a new 4-year R01 from NHLBI to study ACE2 downregulation in hypertension (1/2020).

2019

• Drs. Snigdha Mukerjee and Jiaxi Xu manuscript entitled "ACE2 and ADAM17 interaction regulates the activity of pre-sympathetic neurons" was accepted for publication in Hypertension. (9/2019)
• Dr. Snigdha Mukerjee successfully defended her dissertation. She accepted a postdoctoral position at Vanderbilt University, Nashville, TN.(6/2019)
• Drs. Jiaxi Xu and Ms. Snigdha Mukerjee manuscript entitled "Activation of ADAM17 on glutametergic neurons selectively promotes sympatho-excitation" was accepted for publication in Hypertension. (3/2019) This paper was featured on the Hypertension Trending Topics for April 2019. 
• Dr. Jiaxi Xu was awarded a 3-year Career Development Award from the American Heart Association to study the role of Angiotensin receptors in cognitive impairment (03/2019).
• Dr. Jiaxi Xu and Ms. Snigdha Mukerjee were both selected to receive the Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award from the American Physiological Society. Ms. Mukerjee was also selected to receive a Poster Trainee Award from the APS Central Nervous System section. They will receive their awards at the Experimental Biology meeting to be held in Orlando in April. (2/2019)

2018

• Ms. Snigdha Mukerjee's manuscript entitled "Next generation tools to study in vivo autonomic regulation" was accepted for publication in the Neuroscience Bulletin. (12/2018)
• Drs. Tyler Basting, Jiaxi Xu and Ms. Snigdha Mukerjee's manuscript entitled Glutamatergic neurons of the paraventricular nucleus are critical contributors to the development of neurogenic hypertension was accepted for publication in the Journal of Physiology. (8/2018) This article was also featured in a "Perspective" in the December issue of J. Physiol.
• Dr. Tyler Basting was awarded a 2-year Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32). (6/2018)
• Ms. Alynne Carvalho-Galvão's manuscript entitled Central administration of TRV027 improves baroreflex sensitivity and vascular reactivity in spontaneously hypertensive rats was accepted for publication in Clinical Sciences. (6/2018) 
• Dr. Jiaxi Xu's  manuscript entitled Excessive Glutamate Stimulation Impairs ACE2 Activity Through ADAM17-Mediated Shedding in Cultured Cortical Neurons was accepted for publication in Cellular and Molecular Neurobiology. (5/2018)
• Dr. Lazartigues and his colleague Dr. Catalin Filipeanu (Howard Univ.) received a 4-year Merit Award (I01 BX004294) from the U.S. Department of Veterans Affairs. (5/2018)
• Mr. Robert Fuchs received the American Physiological Society Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award (Experimental Biology meeting, San Diego, CA, April 21-25th, 2018).
• Dr. Jiaxi Xu was distinguished with the American Physiological Society Michael J. Brody Young Investigator Award from the NCAR section (Experimental Biology meeting, San Diego, CA, April 21-25th, 2018).
• Ms. Snigdha Mukerjee was distinguished with the American Physiological Society Outstanding Graduate Student Award from the NCAR section (Experimental Biology meeting, San Diego, CA, April 21-25th, 2018).
• Dr. Jiaxi Xu received the Gordon Research Seminar Best Oral Presentation Award  (Angiotensin Gordon Research Conference, Ventura, CA, February 18-23rd, 2018).
• Ms. Snigdha Mukerjee's editorial entitled Sympathetic nerve activity and neuro-inflammation: Who is in the driver's seat? was accepted for publication in Acta Physiologica. (2/2018)

2017

• Dr. Srinivas Sriramula's manuscript entitled Kinin B1 receptor promotes neurogenic hypertension through activation of centrally-mediated mechanisms was accepted for publication in Hypertension. (9/2017)
• Dr. Srinivas Sriramula accepted a position of Assistant Professor in the Department of Pharmacology at East Carolina University (8/2017).
• Dr. Jiaxi Xu and Dr. Srinivas Sriramula manuscript entitled Clinical Relevance and Role of Neuronal AT₁ Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension was accepted for publication in Circulation Research. (5/2017)
• Ms. Snigdha Mukerjee's manuscript entitled Perinatal exposure to Western diet programs autonomic dysfunction in the male offspring was accepted for publication in Cellular and Molecular Neurobiology. (5/2017)
• Dr. Kim Pedersen and Dr. Harshita Chodavarapu's manuscript entitled Forkhead box transcription factors of the FOXA class are required for basal transcription of ACE2 was accepted for publication in The Journal of the Endocrine Society. (4/2017)
• Dr. Harshita Chodavarapu successfully defended her dissertation. She accepted a postdoctoral position in the Diabetes and Research Institute at Cedars Sinai, CA. (3/2017)
• Dr. Tyler Basting's manuscript entitled DOCA-Salt hypertension: An update was acceppted for publication in Current Hypertension Reports. (3/2017)
• Dr. Srinivas Sriramula and Dr Kim Pedersen's manuscript entitled Determining the Enzymatic Activity of Angiotensin-Converting Enzyme 2 (ACE2) in Brain Tissue and Cerebrospinal Fluid Using a Quenched Fluorescent Substrate was accepted for publication in Methods in Molecular Biology.(2/2017)
• Ms. Harshita Chodavarapu has been selected to receive the American Physiological Society Endocrinology & Metabolism Research Recognition Award,  (Experimental Biology meeting, Chicago, IL, April 22-26th, 2017).
• Dr. Jiaxi Xu has been selected to receive the American Physiological Society VWR-sponsored Experimental Biology Trainee Award  (Experimental Biology meeting, Chicago, IL, April 22-26th, 2017).
• Ms. Snigdha Mukerjee has been selected to receive the American Physiological Society Attoquant-sponsored Experimental Biology Trainee Award from the NCAR section (Experimental Biology meeting, Chicago, IL, April 22-26th, 2017).

2016

• Dr. Lazartigues and his colleagues Drs. Yue and Gardner (Physiology), were awarded a multiple PI R01 (1R01HL135635) entitled "Chronic nicotine inhalation increases susceptibility to cardiovascular and pulmonary diseases through inhibition of local compensatory mechanisms" (12/2016). 
• Ms. Harshita Chodavarapu and Dr. Kavaljit Chhabra's manuscript entitled High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice was accepted for publication in the American Journal of Physiology, Regulatory, Integrative and Comparative Physiology. (10/2016)
• Dr. Jiaxi Xu and Ms. Snigdha Mukerjee's manuscript entitled A disintegrin and metalloprotease 17 in the cardiovascular and central nervous systems was accepted for publication in Frontiers in Physiology. (10/2016).
• Dr. Srinivas Sriramula made an oral presentation entitled œKnockdown of Bradykinin B1 Receptor Reduces Neuro-inflammation and Prevents the Development of Salt-Sensitive Hypertension (Experimental Biology meeting, San Diego, CA, April 2-6th, 2016).
• Dr. Jiaxi Xu made an oral presentation entitled Neuronal activation of ADAM17 by AT1A receptors contributes to neurogenic hypertension. Dr. Xu received the Postdoctoral and Early Career Research Recognition Award from the American Physiological Society Neural Control and Autonomic Regulation section (Experimental Biology meeting, San Diego, CA, April 2-6th, 2016).
• Ms. Snigdha Mukerjee made an oral presentation entitled ACE2 Deletion is Associated with Increased ADAM17 and Reduced Inhibitory Currents to Pre-sympathetic Hypothalamic Neurons. Ms. Mukerjee received the Predoctoral Research Distinction Award from the American Physiological Society Water & Electrolyte section (Experimental Biology meeting, San Diego, CA, April 2-6th, 2016).
• Dr. Jiaxi Xu made an oral presentation entitled ADAM17 in Neurogenic Hypertension: Function and Regulation. Dr. Xu received the Gordon Research Conference Poster Award (Angiotensin Gordon Research Conference, Il Ciocco, Italy, February 21-26th, 2016).

2015

• Ms. Snigdha Mukerjee made an oral presentation entitled ACE2 modulates the excitability of pre-sympathetic neurons in the paraventricular nucleus (X International Symposium on Vasoactive Peptides, Lagoa dos Ingleses, Minas Gerais, Brazil, October 29-31^st 2015:).
• Dr. Jiaxi Xu was awarded a 2-year Post-doctoral fellowship from the American Heart Association Greater SouthEast Affiliate to study the role of ADAM17 and AT1 receptors in neurogenic hypertension (July 2015).
• Dr. Srinivas Sriramula was awarded a 3-year Scientist Development Grant from the American Heart Association Greater SouthEast Affiliate to study the role of bradykinin receptors in neurogenic hypertension (July 2015).