Quicklinks▼
Careers
Citrix Storefront
Contact
Departments & Centers
Donate
Emergency Preparedness
Find Employees
LSU Health New Orleans
Intranet
Moodle
myLSUHSC
Office 365
Office 365 Mail
Patient Care
Remote VPN
Self Service
LSU Health New Orleans
Doan H. Nguyen, PhD
Director, Microarray and Genome Bioinformatics Center, Gene Therapy Program
Instructor, Department of Genetics and Ophthalmology
Director, Microarray and Genome Bioinformatics Center, Gene Therapy Program
Instructor, Department of Genetics and Ophthalmology
533 Bolivar St., Rm 539 CSRB
New Orleans, LA 70112
Phone: (504) 568-4552
Fax: (504) 568-8500
dnguye@lsuhsc.edu
Degrees
BS Biology - 1989
University of Illinois-Urbana Champaign
PhD Department of Cell Biology and Anatomy - 1997
LSU Health Sciences Center, New Orleans
Bio
He received his PhD in Cell Biology and Anatomy from LSUHSC in New Orleans where he also did a post-doctoral fellowship in the Department of Ophthalmology. In 2002, he became a Research Instructor in the Department of Ophthalmology.
In 2007, he joined the Department of Genetics as an Instructor and Director of the Microarray and Genome Bioinformatics Center, LSU Gene Therapy Program.
The major research focus of this laboratory is aging of the lacrimal gland using the Fischer 344 rat model of aging. The lacrimal gland is a major contributor of proteins and fluid to the water layer of the tear film. The tear film is critical to the optical quality of the cornea and, therefore, vision. It helps maintain the cellular structure of the ocular surface, as well as protects the cornea from pathogens. Lacrimal gland secretion is under neural control and the neural circuit that links the cornea to the gland is important for the maintenance of lacrimal gland structure and function. With age, corneal sensation is decreased, hence the neural input to stimulating secretion from the gland is affected leading to changes in lacrimal gland function which affect the integrity of the ocular surface.
Doans laboratory developed a rat dry eye model by disrupting the parasympathetic stimulation of secretion. The model exhibited many symptoms associated with dry eye syndrome.
Gene2Function: we are developing a web service for the mapping of genes to public databases. Users also have the option to upload and share their own database with colleagues, as well as map-enabling their database. Also in the pipeline is the ability to extract, format, and download literature information from the input gene list from microarray experiments.
This research is supported by grants from the NIH NCCR and the Louisiana Biological Research Network (LBRN) entitled LACRIMAL GLAND BIOINFORMATICS: A Neural Connection of Dry Eye and Aging
Research Interests
- Bioinformatics
- DNA microarray
- Aging and dry eye
Selected Publications
Nguyen DH, Valadamu V, Toshida H, Beuerman RW, Loss of parasympathetic innervation leads to sustained expression of pro-inflammatory genes in the rat lacrimal gland, Auton Neurosci 124(1-2): 81-9, 2006.
Nguyen DH, Beuerman RW, Meneray MA, Toshida H, Sensory denervation modulates eIF-2 kinase expression in the rabbit lacrimal gland, Curr Eye Res 31(4): 287-95, 2006.