2020%208:24:31%20AM

Qiang Shen, MD, PhD

Professor

Department of Genetics
Stanley S. Scott Cancer Center
School of Medicine
Louisiana State University Health Sciences Center
Louisiana Cancer Research Center
1700 Tulane Avenue
New Orleans, LA 70112
Email: qshen@lsuhsc.edu
Office: 504-210-2835
Fax: 504-210-2970

 

Degrees

M.D., Kunming Medical University, China (1986)

M.S., General Surgery, Kunming Medical University, China (1989)

Ph.D., The University of Texas Medical Branch. Galveston, Texas (2001)

Postdoc, Baylor College of Medicine, Houston, Texas (2001-2006)

Bio

Dr. Qiang Shen is Professor in the Department of Genetics and the Program Member of the Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center - New Orleans. Dr. Shen received medical degrees from Kunming Medical University and practiced medicine as a physician surgeon in China. Dr. Shen then obtained his Ph.D. degree in Cell Biology from the University of Texas Medical Branch at Galveston. After completion of a postdoctoral training at Baylor College of Medicine, Dr. Shen was promoted to Instructor at Baylor. Dr. Shen was recruited as tenure-track Assistant Professor to The University of Texas M.D. Anderson Cancer Center in 2009 and promoted as Associate Professor with tenure in 2017, before he joined LSUHSC as Professor in 2019.

 

 

Research Interests

Dr. Shen’s laboratory focuses on studying cancer biology, metabolism, cancer prevention, metastasis, and cancer drug development. Dr. Shen’s current research focuses on the role of transcription factors (STAT3, AP-1), metabolism enzymes (glycolytic enzymes), kinases, ion channels, and pro-apoptotic proteins in transformation and metastasis. Shen laboratory has expertise in cancer biology, breast cancer prevention, metastasis, targeted anticancer drug development, and animal models of human cancers, and is collaboratively developing targeted agents for cancer prevention and treatment, including inhibitors of STAT3 and AP-1, glucose metabolism modulators, and activators of pro-apoptotic proteins, etc. Currently, Dr. Shen’s research programs are funded by NIH R01 grants and DOD Breast Cancer Research Program Award. In Career, Dr. Shen has mentored over 20 graduate students, postdocs, and other trainees and published 75 research articles with an h-index of 33 and i10-index of 53, and is a co-inventor of 3 U.S./International patents.

Teaching Activities

Genet 258 Advanced Genomics

Selected Publications

  1. Lu L, Li H, Wu X, Rao J, Zhou J, Fan S, Shen Q. HJC0152 suppresses human non-small cell lung cancer by inhibiting STAT3 and modulating metabolism. Cell Prolif. 2020 Feb 5:e12777. doi: 10.1111/cpr.12777. PMID: 32022328
  2. Liu G, Yin T, Kim H, Ding C, Yu Z, Wang H, Chen H, Yan R, Wold EA, Zou H, Liu X, Ding Y, Shen Q, Zhou J. Structure-Activity Relationship Studies on Bax Activator SMBA1 for the Treatment of ER-Positive and Triple-Negative Breast Cancer. Eur J Med Chem.2019,178:589-605. PMID: 31220676 DOI: 10.1016/j.ejmech.2019.06.004.
  3. Li Z, Zhu T, Xu Y, Wu C, Kong L, Chen J, Mei M, Ren Y, Sun S, Guo W, Zhao M, Wang Y, Jing C, Dong J, Zhou J, Wang X, Zhang L, Shen Q, Zhou X. A novel STAT3 inhibitor HJC0152 exerts potent antitumor activity in glioblastoma. Am J Cancer Res2019;9(4):699-713. PMID: 31105997 PMCID: PMC6511646. http://ajcr.us/files/ajcr0092694.pdf. PMID: 31105997, PMCID: PMC6511646
  4. Li D, Song H, Wu T, Xie D, Hu J, Zhao J, Shen Q, Fang L. MiR-519d-3p suppresses breast cancer cell growth and motility via targeting LIM domain kinase 1. Mol Cell Biochem. 2018 Jul;444(1-2):169-178. doi: 10.1007/s11010-017-3241-4. PMID:29188531. DOI:10.1007/s11010-017-3241-4
  5. Wang Y, Shen Y, Wang S, Shen Q, Zhou X. The role of STAT3 in leading the crosstalk between human cancers and the immune system. Can Letts. 2018 Feb 28; 415:117-128. pii: S0304-3835(17)30769-3. doi: 10.1016/j.canlet.2017.12.003.PMID:29222039
  6. Xu J, Wold EA, Ding Y, Shen Q, and Zhou J. Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection. Molecules. 2018, 23(2). pii: E474. doi: 10.3390/molecules23020474. PMID:29470395
  7. Ding Y, Li D, Ding C, Liu Z, Wold EA, Ye N, Chen H, White MA, Shen Q, Zhou J. Regio- and Stereospecific Synthesis of Oridonin D-ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads. J Med Chem. 2018, 61:2737-2752. PMID:29528645
  8. Li D, Wang H, Ding Y, Zhang Z, Zheng Z, Dong J, Kim H, Meng X, Zhou Q, Fang L, Zhou J, Shen Q. Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis. Can Letts. 2018, 424:97-108. PMID:29580806
  9. Lu L, Dong J, Wang L, Xia Q, Zhang D, Yang Z, Fan S, Shen Q. Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide. Oncogene, 2018 Sep;37(39):5292-5304. doi: 10.1038/s41388-018-0340-y. PMID: 29855616
  10. Li D, Wang H, Song H, Xu H, Zhao B, Wu C, Hu J, Wu T, Xie D, Zhao J, Shen Q, Fang L. The microRNAs miR-200b-3p and miR-429-5p target the LIMK1/CFL1 pathway to inhibit growth and motility of breast cancer cells. Oncotarget. 2017 Jul 12;8(49):85276-85289. doi: 10.18632/oncotarget.19205.PMID:29156719
  11. Wang Y, Wang S, Wu Y, Ren Y, Li Z, Yao X, Zhang C, Ye N, Jing C,  Dong J, Zhang K, Sun S, Zhao M, Guo W, Qu X, Qiao Y, Chen H, Kong L, Jin R, Wang X, Zhang L, Zhou J, Shen Q, Zhou X. Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152. Mol Cancer Ther. 2017; 16(4):578-590. PMID:28138036
  12. Ding Y, Ding C, Ye N, Liu Z, Wold EA, Chen H, Wild C, Shen Q, Zhou J. Discovery and development of natural product oridonin-inspired anticancer agents. Eur J Med Chem. 2016;122:102-117. doi: 10.1016/j.ejmech.2016.06.15. PMID:27344488
  13. Sun S, Zhou X, Huang Y, Kong L, Mei M, Guo W, Zhao M, Ren Y, Shen Q, and Zhang L. Targeting STAT3/miR-21 Axis Inhibits Epithelial-Mesenchymal Transition via Regulating CDK5 in Head and Neck Squamous Cell Carcinoma. Molecular Cancer. 2015; 14(1):213. doi: 10.1186/s12943-015-0487-x. PMID: 26690371, PMCID: PMC4687320 DOI: 10.1186/s12943-015-0487-x
  14. Xiong A, Yang Z, Shen Y, Zhou J, Shen Q. Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers (Basel) 6(2):926-57, 2014. PMID:24743778, PMCID:PMC4074810, DOI: 10.3390/cancers6020926.
  15. Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014; 82:195-203. PMID:24904966, PMC:4096847
  16. Ye N, Ding Y, Wild C, Shen Q, Zhou J. Small Molecule Inhibitors Targeting Activator Protein 1 (AP-1). J Med Chem. 2014; 57(16):6930-48. PMID:24831826, PMC:4148154
  17. Ding C, Wang L, Chen H, Wild C, Ye N, Ding Y, Wang T, White MA, Shen Q, Zhou J. ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. Org Biomol Chem. 2014; 12(42):8442-52.  PMID:25225052, PMC:4192081
  18. Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013; 4(2):180-185. PMID:23459613, PMC:3583367
  19. Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Fragment-Based Drug Design and Identification of HJC0123, A Novel Orally Bioavailable STAT3 Inhibitor for Cancer Therapy. Eur J Med Chem. 2013; 62:498-507. PMID:23416191, PMC:3750725
  20. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility. J Med Chem. 2013; 56(1):5048-5058. PMID:23746196, PMC:3712786
  21. Ding C, Zhang Y, Chen H, Wild C, Wang T, White MA, Shen Q, Zhou J. Overcoming Synthetic Challenges of Oridonin A-Ring Structural Diversification: Regio- and Stereoselective Installation of Azides and 1,2,3-Triazoles at the C-1, C-2, or C-3 Position. Org Letts. 2013; 15(14):3718-3721. PMID:23834026, PMC:3779473
  22. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis. J Med Chem. 2013; 56(21):8814-25. PMID:24128046, PMC:3880594
  23. Shen Q, Uray IP, Li Y, Krisko TI, Strecker TE, Kim HT, Brown PH. The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors. Oncogene. 2008; 7(3):366-77. PMID:17637753
  24. Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH. Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors. Cancer Prev Res (Phila Pa). 2008; 1(1):45-55. PMID:19138935, PMC:2577387
  25. Shen Q, Brown PH. Transgenic mouse models for the prevention of breast cancer. Mutat Res. 2005; 576(1-2):93-110. PMID:15888345
  26. Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH. The AP-1 transcription factor regulates postnatal mammary gland development. Dev Biol. 2006; 295(2):589-603. PMID:16678816
  27. Shen Q, Singh P. Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. Oncogene. 2004; 23(14):2454-64. PMID:14767471 DOI: 10.1038/sj.onc.1207354
  28. Shen Q, Brown PH. Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways. J Mammary Gland Biol Neoplasia. 2003; 8(1):45-73. PMID:14587863

Additional Info

Instructor, Baylor College of Medicine (2006-2009)

Assistant Professor (tenure track), The University of Texas MD Anderson Cancer Center (2009 - 2017)

Associate Professor (with tenure), The University of Texas MD Anderson Cancer Center (2017 - 2019)

Professor, Louisiana State University Health Sciences Center – New Orleans (2019 - present)