Xi

Xi, Yaguang
MD, PhD, MBA

Amgen Oncology Professor
Vice Chair for Research

Department of Genetics
School of Medicine
LSU Health Sciences Center
533 Bolivar Street
New Orleans, LA 70112
Tel: 504-517-5819
Email: yxi@lsuhsc.edu

Degrees

MD, Inner Mongolia Medcial University, China (1996)
PhD, Peking University Health Science Center, China (2003)
MBA,  University of South Alabama (2012)

Bio

Dr. Yaguang Xi is a Professor and Vice Chair for Research of the Department of Genetics and a Program Member of Stanley S. Scott Cancer Center. Prior to pursuing his PhD at Peking University, Dr. Xi practiced as a general surgeon. His research interests include non-coding RNA, tumor metastasis, cancer chemoprevention, immunotherapy, and new drug development. His research projects are funded by NIH R01, P20, R21 grants, and American Cancer Society Research Scholar Award.

 

Research Interests

1. Discovery and validation of novel biomarkers associated with tumor progression, metastasis, treatment response, and chemoprevention.
2. Identification and characterization of important roles of non-coding RNAs (microRNAs) in human cancers.
3. Study of the regulatory role of sulindac in immunotherapy.
4. Development of new normalization methods for microarray analysis.

Teaching Activities

Genet 258 Advanced Genomics

CSI 100/200

Selected Publications

  1. Zhipin Liang, Zhiqiang Qin, Adam Riker, Yaguang Xi*.2020. CRISPR/Cas9 ablating viral microRNA promotes lytic reactivation of Kaposi's sarcoma-associated herpesvirus. Biochem Biophys Res Commun. 533(4):1400-1405.
  2. Xiaolin Liu, Ruixia Ma, Bin Yi, Adam Riker*, Yaguang Xi*. 2020. MicroRNAs are involved in the development and progression of gastric cancer. Acta Pharmacol Sin. 2020 Oct 9. doi: 10.1038/s41401-020-00540-0. Online ahead of print.
  3. Ruixia Ma, Bin Yi, Adam Riker*, Yaguang Xi*. 2020. Metformin and cancer immunity. Acta Pharmacol Sin. 41(11):1403-1409
  4. Zhipin Liang, Yaguang Xi*.2016. MicroRNAs mediate therapeutic and preventive effects of natural agents in breast cancer.  Chin J Nat Med. 14(12):881-887
  5. Bin Yi, Hong Chang, Xiangling Feng, Ruixia Ma, Gary A. Piazza, Yaguang Xi*.2016. A novel sulindac derivative inhibits breast cancer motility through suppression of TGFβ/miR-21 signaling. Oncotargets. 7(7):7979-92.
  6. Hong Chang, Bin Yi, Ruixia Ma, Xiaoguo Zhang, Hongyou Zhao, Yaguang Xi*. 2016.  CRISPR/cas9, an innovative genomic tool to knock down microRNA in vitro and in vivo.Scientific Reports. 6:22312.
  7. Ruixia Ma, Bin Yi, Gary A. Piazza, Yaguang Xi*.2015. Mechanistic role of microRNA in cancer chemoprevention by nonsteroidal anti-inflammatory drugs. Current Pharmacology Reports. 1(3):154-160.
  8. Xiangling Feng, Zhengming Wang, Rebecca Fillmore, Yaguang Xi*.2014. MiR-200, a new star microRNA in human cancer. Cancer Letters. 344(2):166-7
  9. Bin Yi, Gary A. Piazza, Xiulan Su, Yaguang Xi*. 2013. MicroRNA and Cancer Chemoprevention. Cancer Prev Res (Phila). 6(5):401-9.
  10. Bin Wang*, Shu-Guang Zhang, Xiao-Feng Wang, Ming Tan, Yaguang Xi*. 2012. Testing for Differentially-Expressed MicroRNAs with Errors-in-Variables Nonparametric Regression. PLoS One.7(5):e37537.
  11. Xiaobo Li, Junwu Zhang, Lin Gao, Steve McClellan, Michael A. Finan, Thomas W. Butler, Laurie B. Owen, Gary A. Piazza, Yaguang Xi*.2012. MiR-181 mediates cell differentiation by interrupting the Lin28 and let-7 feedback circuit. Cell Death & Differentiation. 19(3):378-386.
  12. Xiaobo Li, Lin Gao, Qinghua Cui, Bernard D. Gary, Donna Lynn Dyess, William Taylor, Lalita A. Shevde, Rajeev S. Samant, Windy Dean-Colomb, Gary A. Piazza, Yaguang Xi*.2012. Sulindac inhibits tumor cell invasion by suppressing NF-κB mediated transcription of microRNAs. Oncogene. 31(48):4979-86
  13. Lin Gao, YanhuiGao, Xiaobo Li, Paul Howell, Rajeev Kumar, Xiulan Su, Alexander V. Vlassov, Gary A. Piazza, Adam I. Riker, Dianjun Sun, Yaguang Xi*. 2012. Aquaporins mediate the chemoresistance of human melanoma cells to arsenite. Molecular Oncology.6(1):81-87

Additional Info

Membership in Professional Organizations:
2004-Present    American Association for Cancer Research (Active Member)
2005-Present    American Society of Clinical Oncology (Active Member)
2012-Present    International Honor Society Beta Gamma Sigma (Lifetime Member)
2014-Present    American Association for the Advancement of Science (Member)
2015-Present    Society of Chinese Bioscientists in America (Member)

Center of Excellence

Stanley S. Scott Cancer Center