Michael S. Lan, PhD

Professor, Department of Genetics/Pediatrics
Louisiana State University Health Sciences Center, New Orleans
Children’s Hospital Professorship of Pediatric Research


1976 - B.S. in Chemistry, SooChow University, Taiwan, R.O.C.
​1980 - M.S. in Molecular Biology, Tsing Hua University, Taiwan, R.O.C.
1986 - Ph.D. in Microbiology and Immunology, Duke University, Durham, NC USA

Research Interests

  • Study of transcription factor in neuroendocrine differentiation
  • Study of insulin autoimmunity, tolerance, and type 1 diabetes
  • Study of INSM1 functional role in neuroendocrine transformation
  • Targeting INSM1-associated signaling axis in neuroendocrine tumors for new drug discovery and therapy

Selected Publications

  1. Tseng, A.W., Akerstrom, V., Chen, C., Breslin, M.B., and Lan, M.S.: Detection of neuroendocrine tumors using promoter-specific secreted Gaussia luciferase. Int. J. Oncol., 48: 173-180, 2016.
  2. Sparks, A.E., Chen, C., Breslin, M.B., and Lan, M.S.: Functional domains of autoimmune regulator, AIRE, modulate INS-VNTR transcription in human thymic epithelial cells. J. Biol. Chem., 291: 11313-11322, 2016.
  3. Tseng, A.W., Chen, C., Breslin, M.B., and Lan, M.S.: Tumor-specific promoter driven therapy for insulinoma. Cell. Oncol., 39: 279-286, 2016.
  4. Chen, C., Breslin, M.B., and Lan, M.S.: Ectopic expression of a small cell lung carcinoma transcription factor, INSM1, impairs alveologenesis in lung development. BMC Pulmonary Medicine, 16: 49-58, 2016.
  5. Chen, C., Breslin, M.B., and Lan, M.S.: Sonic hedgehog signaling pathway regulates INSM1 transcription factor in neuroendocrine lung cancer. Cell. Signal. 46: 83-91, 2018.
  6. Wang, L., Sun, Z.S., Xiang, B., Wei, C., Wang, Y., Sun, K., Chen, G., Lan, M.S., Carmona, G.N., Notkins, A.L., and Cai, T.: Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance. J. Transl. Med., 16: 297-305, 2018.
  7. Chen, C., Breslin, M.B., Guidry, J.J., and Lan, M.S.: 5’-iodotubercidin represses insulinoma-associated-1 expression, decreases cAMP levels, and suppresses human neuroblastoma cell growth. J. Biol. Chem., 294: 5456-5465, 2019.
  8. Chen, C., Notkins, A.L., and Lan M.S.: Insulinoma-associated-1 (IA-1/INSM1): From neuroendocrine tumor marker to cancer therapeutics. In press. Mol. Cancer Res., 17(8): 1597-1604, 2019.
  9. Chen C, Lan M.S.A promoter-driven assay for INSM1-associated signaling pathway in neuroblastoma. Cell Signal., 76: 109785, 2020.

Additional Info