Scott Edwards, Ph.D.
Assistant Professor of Physiology and Neuroscience
Department of Physiology
Office: MEB 7208
Department of Physiology
Office: MEB 7208
B.S. Biochemistry (2000)
Ph.D. Neuroscience (2007)
Dr. Edwards completed his PhD training in the Departments of Neuroscience and Psychiatry at the UT Southwestern Medical Center at Dallas with the support of a predoctoral National Research Service Award (NRSA) from the National Institute on Drug Abuse. Afterwards, Scott joined the Committee on the Neurobiology of Addictive Disorders at The Scripps Research Institute where he was awarded a postdoctoral NRSA fellowship and a K99/R00 Pathway to Independence award from the National Institute on Alcohol Abuse and Alcoholism. Dr. Edwards joined the Department of Physiology in 2013.
Research interests in our laboratory center around the investigation of neurobiological changes associated with altered motivational systems in drug and alcohol addiction. Our research strategy is to first determine alterations in neuronal signaling following excessive drug or alcohol use, and then to investigate which neuroadaptations are most critically involved in driving excessive drug intake. A closely associated goal is to understand signaling changes induced by re-exposure to drug- or stress-paired contexts and how these processes may contribute to relapse and other motivational disorders. Our most recent focus is on the interaction of addiction and chronic pain. Employing animal models of these conditions, we are investigating how inflammatory pain alters central reinforcement circuitry and motivated behavior.
Our studies primarily measure protein- and phosphoprotein-level neuroadaptations in brain centers responsible for the establishment and maintenance of the addicted state. We are able to manipulate molecular targets within specific brain regions through a variety of technologies, including viral-mediated gene overexpression and knockdown strategies. These projects involve close collaboration with distinguished LSU Health and national investigators.
Role of GluA1 in the Escalation of Alcohol Drinking in Nicotine-Dependent Animals (R21AA025736 Edwards PI)
Prepro-Dr. Adrienne McGinn was recently awarded a prestigious Individual National Research Service Award from the NIH to support her investigation into glucocorticoid signaling in the prefrontal cortex and its contributions to chronic pain and alcohol dependence.
Edwards S, Molina PE, McDonough K, Mercante DE, Gunaldo TP. The potential of interprofessional education to effectively translate physiology curricula into future team-based healthcare. Submitted.
|Committees & Administrative Responsibilities|
Juarez B, Morel C, Ku SM, Ribeiro E, Zhang H, Crumiller M, Jackson K, Roman-Ortiz C, Croote D, Calipari ES, Zhang S, Hodes G, Liu Y, Cederbaum AI, Vendruscolo LF, Edwards S, Roberts A, Chaudhury D, Friedman AK, Koob GF, Han MH. Midbrain circuit regulation of individual alcohol drinking behaviors in mice. Nature Communications (In press).
Pahng AR, Paulsen RI, McGinn MA, Edwards KN, Edwards S. Neurobiological correlates of pain avoidance-like behavior in morphine-dependent and non-dependent rats. Neuroscience (In press).
Pahng AR, McGinn MA, Paulsen RI, Edwards S. The prefrontal cortex as a critical gate of negative affect in alcohol use disorder. Current Opinion in Behavioral Sciences. 2017 13: 139-143.
Mayeux JP, Katz PS, Edwards S, Middleton JW, Molina PE. Inhibition of endocannabinoid degradation improves outcomes from mild traumatic brain injury: A mechanistic role for synaptic hyperexcitability. Journal of Neurotrauma. 2017 34: 436-443.
McGinn MA, Paulsen RI, Itoga CA, Farooq MA, Reppel JE, Edwards KN, Whitaker AM, Gilpin NW, Edwards S. Withdrawal from chronic nicotine exposure produces region-specific tolerance to alcohol-stimulated GluA1 phosphorylation. Alcohol: Clinical and Experimental Research. 2016 40:2537-2547
Somkuwar SS, Staples MC, Fannon M, Zamora-Martinez ER, Kim A, Navarro AI, Edwards S, Mandyam CD. Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. Brain Structure and Function. 2016 221:4319-4335.
McGinn MA, Edwards S. CRF1 receptor signaling at the intersection of pain and opioid addiction. In: Preedy V (Ed.) The Neuropathology of Drug Addictions and Substance Misuse. 2016 1: 891-896. Academic Press.
Whitaker AM, Farooq MA, Edwards S, Gilpin NW. Post-traumatic stress avoidance is attenuated by corticosterone and associated with brain levels of steroid receptor co-activator-1 in rats. Stress. 2016 19: 69-77.
LeBlanc D, McGinn MA, Itoga CA, Edwards S. The affective dimension of pain as a risk factor for drug and alcohol addiction. Alcohol. 2015 49:803-809.
Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol dependent individuals. Journal of Clinical Investigation. 2015 125: 3193-3197.
Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addiction Biology 2015 20: 275-284.
Helms CM, Anderson SM, Bell RL, Bennett AJ, Davies DL, Kosten TA, Leeman R, Panicker S, Platt DM, Weiner JL, Edwards S. The importance of animals in advancing research on alcohol use disorders. Alcoholism: Clinical and Experimental Research. 2015 39: 575-578.
Whitfield TW Jr, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Crawford E, Edwards S, Vendruscolo LF, Koob GF. Kappa opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of Neuroscience. 2015 35: 4296-4305.
Kim A, Zamora-Martinez ER, Edwards S, Mandyam CD. Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol-dependent rats is associated with altered glial plasticity. Brain Structure and Function. 2015 220: 1705-1720.
Katz PS, Edwards S, Molina PE. Cannabinoids. In: Peterson PK and Toborek M (Eds.) Neuroinflammation and Neurodegeneration. 2014 XVII: 487-510. Springer: New York.
Zamora-Martinez ER, Edwards S. Neuronal extracellular signal-regulated kinase (ERK) signaling as marker and mediator of alcohol and opioid dependence. Frontiers in Integrative Neuroscience 2014 8:24.
Edwards S, Baynes BB, Carmichael C, Zamora-Martinez ER, Koob GF, Gilpin NW. Traumatic stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Translational Psychiatry 2013 3: e296.
Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of addiction liability. Behavioural Pharmacology 2013 24: 356-362.
Kallupi M, Wee S, Edwards S, Whitfield TW Jr, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biological Psychiatry 2013 74(7): 520-528.
Schlosburg JE, Vendruscolo LF, Bremer P, Lockner JW, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Heroin vaccine blocks relapse and compulsive intake of heroin. Proceedings of the National Academy of Sciences U.S.A. 2013 110(22): 9036-9041.
Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews 2012 36: 2179-2192.
Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity during ethanol dependence and extended access to heroin self-administration: alleviation by CRF1 receptor antagonism. Neuropharmacology 2012 62(2): 1142-1151.
Edwards S, Guerrero M, Ghoneim O, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addiction Biology 2012 17(1): 76-85.
Edwards S, Koob GF. Psychiatric illness and drug abuse models: from human to animal – an overview. In: Kobeissy FH (Ed.) Psychiatric Disorders: Methods and Protocols (series title: Methods in Molecular Biology) 2012 829: 31-48. Humana Press: New York.
Edwards S, Whisler KN, Bachtell RK, Guzman D, Self DW. Emergence of context-associated GluR1 and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration. Addiction Biology 2011 16(3): 450-457.
Edwards S, Koob GF. The neurobiology of dysregulated motivational systems in drug addiction. Future Neurology 2010 5(3): 393-410.
Taffe MA, Kotzebue RW, Crean RD, Crawford EF, Edwards S, Mandyam CD. Alcohol consumption in nonhuman primates persistently reduces hippocampal neurogenesis by decreasing active division of preneuronal progenitors. Proceedings of the National Academy of Sciences U.S.A. 2010 107(24): 11104-11109.
Orio L, Edwards S, George O, Parsons L, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in dependence. The Journal of Neuroscience 2009 29(15): 4846-4857.
Edwards S, Whisler KN, Fuller D, Orsulak PJ, Self DW. Addiction-related alterations in D1 and D2 dopamine receptor responsiveness following chronic cocaine self-administration. Neuropsychopharmacology 2007 32: 354-366.
Graham DL, Edwards S, Bachtell RK, DiLeone RJ, Rios M, Self DW. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nature Neuroscience 2007 10(8): 1029-1037.
Edwards S, Self DW. Monogamy: Dopamine ties the knot. Nature Neuroscience 2006 9(1): 7-8.
Edwards S, Simmons DL, Galindo DG, Doherty JM, Scott AM, Hughes PD, Wilcox RE. Antagonistic effects of dopaminergic drugs and ethanol on PKA-mediated phosphorylation of DARPP-32 and the NR1 subunit of the NMDA receptor. Alcoholism: Clinical and Experimental Research 2002 26(2): 173-80.
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