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Xia, Huijing

Assistant Professor - Research

LSU Health Sciences Center - New Orleans
533 Bolivar St., CSRB 409C

Phone: 504-568-2330
Fax: 504-568-3247
hxia1@lsuhsc.edu

 

Degrees

Ph.D. Pharmacology, 2006
China Pharmaceutical University, Nanjing, China

Bio

Click here for Biosketch

Research Interests

The role of Angiotensin Converting Enzyme 2 (ACE2) in the central regulation of metabolism.

Committees & Administrative Responsibilities
  • American Physiological Society
  • American Heart Association
  • American Autonomic Society
Selected Publications
  1. Feng Y., Yue X., Xia H., Bindom S.M., Hickman P.J., Filipeanu C.M., Wu G. & Lazartigues E. ACE2 over-expression in the subfornical organ prevents the Angiotensin-II-mediated pressor and drinking responses and is associated with AT1 receptor down-regulation. Circulation Research, 2008; 102(6):729-736. PMID: 18258853. PMCID: PMC2279097.
  2. Xia H. & Lazartigues E. Angiotensin converting enzyme 2 in the brain: properties and future directions. (Invited Review) Journal of Neurochemistry, 2008;107:1482-1494. PMID: 19014390; PMCID: PMC2667944
  3. Xia H., Feng Y., Obr T.D., Hickman P.J. & Lazartigues E. AT1 receptor-mediated reduction of ACE2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension, 2009; 53(2):210-216 (Cover of the February 1st issue of Hypertension). PMID: 19124678. PMCID: PMC2695598.
  4. Hans C.P., Feng Y., Naura A.S., Zerfaoui M., Rezk B., Xia H., Kaye A.D., Matrougui K., Lazartigues E. & Boulares H. Protective Effects of PARP-1 Knockout on Dyslipidemia Induced Autonomic and Vascular Dysfunction in ApoE–/– Mice: Effects on eNOS and Oxidative StressPLoS One, 2009; 4(10):e7430.
  5. Feng Y., Xia H., Cai Y., Halabi C.M., Sigmund, C.D. & Lazartigues E. Brain-selective Overexpression of Human Angiotensin-Converting Enzyme 2 Attenuates neurogenic Hypertension. Circulation Research, 2010; 106(2):373-382. (Cover Figure). PMID: 19926873; PMCID: PMC2818798
  6. Feng Y., Xia H., Santos R.A., Speth R. & Lazartigues E. ACE2: A new target for neurogenic hypertensionExperimental Physiology, 2010; 95 :601-606. PMID: 19923158; PMCID: PMC2858233
  7. Xia H. & Lazartigues E. Angiotensin converting enzyme 2: Central regulator for cardiovascular functionCurrent Hypertension Reports, 2010; 12(3):170-175. PMID: 20424953; PMCID: PMC3093757
  8. Bindom S.M., Hans C.P., Xia H., Boulares H & Lazartigues E. Angiotensin-I Converting Enzyme type 2 (ACE2) gene therapy improves glycemic control in diabetic miceDiabetes, 2010; 59(10):2540-2548. PMID: 20660625; PMCID: PMC3279528
  9. Xia H., Suda S., Bindom S.M., Feng Y., Gurley S., Seth D., Navar G. & Lazartigues E. ACE2-Mediated Reduction Of Oxidative Stress In The Central Nervous System Is Associated With Improvement Of Autonomic Function.PLoS ONE, 2011;6(7):e22682. PMID: 21818366; PMCID: PMC314492
  10. Perdersen K., Xia H., Sriramula S., Chhabra K. & Lazartigues E. Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays.American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 2011; 301(5):R1293-R1299. PMID: 21880865; PMCID: PMC3213941
  11. Chhabra K., Xia H., Pedersen K & Lazartigues E. Pancreatic Angiotensin-Converting Enzyme 2 (ACE2) protects against impaired glycemic control in angiotensin II-infused mice.AJP-Endocrinology and Metabolism 2013 ; 304(8) :E874-884. PMID:23462816. PMCID: PMC 3625779
  12. Xia H., Sriramula S., Chhabra K. & Lazartigues E. Brain ACE2 shedding contributes to the development of neurogenic hypertensionCirculation Research. 2013;113:1087-1096. PMID: 24014829
  13. Pedersen K.B., Chhabra K., Nguyen V.K., Xia H. & Lazartigues E. The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs. Biochim. Biophys. Acta. 2013;1829(11):1225-1235. PMID:24100303

 

In The News

2008             Caroline Tum Suden/Frances A. Hellebrandt Professional Opportunity Award from The American Physiological Society

2008             Van Harreveld Memorial Award from The American Physiological Society CNS section

 

2008             Travel Award from The American Physiological Society for the Beijing Joint Conference of Physiological Sciences 2008

 

2008             Travel Award from the LSUHSC-NO Vice-Chancellor for Academic Affairs (Beijing Joint Conference of Physiological Sciences 2008)

 

2008             New Investigator Travel Award from The American Heart Association for 62nd High Blood Pressure Research Conference 2008

 

2009             Travel Award from The American Physiological Society for Professional Skills Training Courses (Writing and Reviewing for Scientific Journals)

 

2009             Research Recognition Award from The American Physiological Society CNS section

 

2009             Travel Award from the LSUHSC Neuroscience Center

 

2009             Postdoctoral Fellowship in Physiological Genomics from The American Physiological Society (2009-2011)

 

2009             Travel Fellowship Award from The American Autonomic Society for the 20th International Symposium on the Autonomic Nervous System

 

2010             Poster Award from FASEB at the 2010 Summer Research Conference Neural Mechanisms in Cardiovascular Regulation

 

2010             New Investigator Award from The American Heart Association at the 64th High Blood Pressure Research Conference 2010

 

2011             New Investigator Award from The Inter-American Society of Hypertension at the Joint Meeting of the 65th High Blood Pressure Research Conference/Inter-American Society of Hypertension 2011

 

2011             Presentation Award from The International Society of Hypertension at the Joint Meeting of the 65th High Blood Pressure Research Conference/Inter-American Society of Hypertension 2011

 

2012             Research Recognition Award from The American Physiological Society NCAR section

 

2013             Co-chair & Invited Speaker for Featured Topic “Brain Renin-Angioteinsin signaling in metabolic diseases” at Experimental Biology meeting 2013.

 

2014-2015    Member of the Award Committee of The American Physiological Society