2016 12:40:17 PM

Jeff Gidday, PhD

Professor of Ophthalmology, Neuroscience, and Physiology

Clinical Sciences Research Building, Room 454
533 Bolivar St.
New Orleans, LA 70112

(O): 504.568.2360 





BS, Biological Sciences
University of Michigan, Ann Arbor

PhD, Physiology
University of Virginia, Charlottesville

Clinical Interests


Retinal disease

Retinal neurodegeneration



Vascular dementia

Traumatic central nervous system injury

Research Interests

Endogenous neuroprotection for glaucoma and other central nervous system axonopathies

Adaptive epigenetics

Intergenerational epigenetics

Central nervous system neurovascular protection


Ischemic and other retinopathies


Vascular cognitive impairment

Neonatal brain injury



Selected Publications

Gidday, J.M.  Cerebral preconditioning and ischemic tolerance.  Nat. Neurosci. Rev. 7: 437-448, 2006.

Zhu, Y., Y. Zhang, B.A. Ojwang, M.A. Brantley Jr., J.M. Gidday.  Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning:  Role of HIF-1α and heme oxygenase-1. Invest. Ophthalmol. Vis. Sci. 48: 1735-1743, 2007.

Gidday, J.M.  Pharmacologic preconditioning:  Translating the promise.  Transl. Stroke Res. 1: 19-30, 2010.

Stowe, A.M., T. Altay, A.B. Freie, J.M Gidday.  Repetitive hypoxia extends endogenous neurovascular protection for stroke.  Ann. Neurol. 69:975-985, 2011.

Stowe, A.M., B.K. Wacker, P.D. Cravens, J.L. Perfater, M.K. Li, R. Hu, A.B. Freie, O. Stuve, J.M. Gidday.  CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke.  J. Neuroinflammation 9: 33, 2012.

Zhu, Y., L. Zhang, J.F. Schmidt, J.M. Gidday.  Glaucoma-induced injury of retinal ganglion cell soma and axons prevented by hypoxic preconditioning:  A model of ‘glaucoma tolerance’.  Mol. Medicine 18: 697-706, 2012.

Wacker, B.K., J.L. Perfater, J.M. Gidday.  Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway.  J. Neurochem. 123: 954-962, 2012.

Zhu, Y., Y. Sasaki, L. Zhang, J. Milbrandt, J.M. Gidday.  Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.  Invest. Ophthalmol. Vis. Sci. 54: 25-36, 2013.

McLaughlin, BA and J.M. Gidday.  Poised for success:  Implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients.  Transl. Stroke Res. 4: 104-113, 2013.

Zhu, Y., L. Zhang, J.M. Gidday.  Role of HIF-1α in preconditioning-induced protection of retinal ganglion cells in glaucoma.  Mol. Vis. 19: 2360-2373, 2013.

Gidday, J.M., L. Zhang, Y. Zhu.  Enhanced retinal ganglion cell survival in glaucoma by hypoxic postconditioning after disease onset.  NeuroTherapeutics 12:502-514, 2015.

Gidday, J.M.  Extending injury- and disease-resistant CNS phenotypes by repetitive epigenetic conditioning.   Front. Neurol. 6:42, 2015.

Gidday, J.M.  Cerebrovascular ischemic protection by pre- and post-conditioning.  Brain Circulation 1: 97-103, 2015.

Selvaraj, U.M., S.B. Ortega, R. Hu, R. Gilchrist, A. Partin, E.J. Plautz, R.S. Klein, J.M. Gidday*, A.M. Stowe*.  Upregulation of CXCL12 at the BBB in response to repetitive hypoxic preconditioning contributes to the ischemia-tolerant, anti-inflammatory phenotype.  J. Cereb. Blood Flow Metab. 37:801-813, 2017.

Harman, J.C., J.J. Guidry, J.M. Gidday.  Comprehensive characterization of the adult Swiss Webster-ND4 mouse retina: Using discovery-based mass-spectroscopy to decipher the total proteome and phosphoproteome.  Mol. Vis. 24:875-889, 2018.

Leak R.K., E.J. Calabrese, W.J. Kozumbo, J.M. Gidday, T.E. Johnson, J.R. Mitchell, C.K. Ozaki, R. Wetzker, M.E. Anderson, A. Bast, R.G. Belz, H.E. Bøtker, S. Koch, M.P. Mattson, R.P. Simon, R.J. Jirtle, M.E. Anderson.  Enhancing and extending biological performance and resilience. Dose-Response 16(3):1559325818784501, 2018.

Gidday, J.M.  Adaptive plasticity in the retina:  Protection against acute injury and neurodegenerative disease by conditioning stimuli.  Conditioning Medicine 1: 85-97, 2018.

Ruden, J.B., K.L. Quick, E.R. Gonzales, A.R. Shah, T.S. Park, N. Kennedy, L.L. Dugan, J.M. Gidday.  Reduction of leukocyte microvascular adherence and preservation of blood-brain barrier function by superoxide-lowering therapies in a piglet model of neonatal asphyxia.  Frontiers Neurol2019, doi: 10.3389/fneur.2019.00447 

Center of Excellence