School of Medicine

Department of Genetics

Research Interests of Faculty Members


Judy Crabtree, Ph.D., Associate Professor  - Research

  • Understanding biological processes & epigenetics of endocrine tumor disorders.
  • Epigenetics of adaptive pancreatic islet expansion associated with obesity, pregnancy, and T2D
  • miRNA influences on pancreatic neuroendocrine tumorigenesis via MEN1 and RBP2.

Edward Grabczyk, Ph.D., Associate Professor

  • Progressive genetic disorders caused by DNA repeat expansion such as Friedreich ataxia.
  • Interactions between transcription, DNA structure and DNA mismatch repair that drive repeat expansion diseases.

Andrew Hollenbach, Ph.D., Professor

  • The regulation of transcription factors through phosphorylation
  • Biochemical mechanisms of chromosomal translocation gene products in cancer formation
  • Gene regulation in melanoma development
  • The use of genomics and

Michael Lan, Ph.D., Professor (Pediatrics)

  • Transcription factors in neuroendocrine differentiation
  • Insulin gene regulation via INS-VNTR and AIRE in human tymic epithelial cells
  • Role of islet transcription factor in endocrine pancreas development
  • Mechanisms of neuroendocrine transformation and therapeutic study

Wanguo Liu, Ph.D., Associate Professor

  • Genetics and biological roles of Wnt signaling in GI tumor development
  • Genetics and functional analysis of DNA damage-response defects in prostate cancer susceptibility

Diptasri Mandal, Ph.D., Professor

  • Genetic Epidemiology of hereditary lung cancer and prostate cancer in the population in Louisiana
  • Genetic linkage and association analyses of complex disorders, in particular humans cancers
  • Copy Number Variations (CNVs) in hereditary prostate cancer families

Lucio Miele, M.D., Ph.D., Professor

  • Studies of cancer stem cell-regulatory genes such as Notch, and identification of genetic circuitry mediating Notch signals in human tumors
  • Correlation between GWAS data and transcriptome for cancer-associated genes
  • Mechanism-based early clinical trials using genomic biomarkers as correlative endpoints and/or stratification variables.

Fern Tsien, Ph.D., Associate Professor

  • Neuroinflammation gene expression changes caused by pediatric cancer treatments, e.g., methotrexate
  • Genetics of auditory and communication disorders
  • Chromatin instability in disorders that affect the Louisiana Acadian population
  • Evaluation tools in science education