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Selected Publications:
Li S, Gordon WC, Bazan NG, and Jin M. (2020) Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation. Proc Natl Acad Sci U S A, 117: 32114-23.
Mia Langbøl, Sarkis Saruhanian, Thisayini Baskaran, Daniel Tiedemann, Zaynab A. Mouhammad, Anne Katrine Toft-Kehler, Bokkyoo Jun, Rupali Vohra, Nicolas G. Bazan, Miriam Kolko. Increased Antioxidant Capacity and Pro-Homeostatic Lipid Mediators in Ocular Hypertension—A Human Experimental Model.Journal of Clinical Medicine, 2020; 9 (9): 2979 DOI: 10.3390/jcm9092979
Pham TL, He J, Kakazu AH, Calandria J, Do KV, Nshimiyimana R, Petasis NA, Bazan HEP, Bazan NG. Elovanoid-N32 or RvD6-isomer decrease ACE2 and binding of S protein RBD after injury or INFγ in the eye. Research Square. 2020 PMID 32818210 DOI: 10.21203/rs.3.rs-55764/v1
Belayev L, Hong SH, Freitas RS, Menghani H, Marcell SJ, Khoutorova L, Mukherjee PK, Reid MM, Oria RB, Bazan NG. DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke. Cns Neuroscience & Therapeutics. 2020 PMID 32757264 DOI: 10.1111/cns.13444
Bazan HA, Bhattacharjee S, Burgos C, Recio J, Abet V, Pahng AR, Jun B, Heap J, Ledet AJ, Gordon WC, Edwards S, Paul D, Alvarez-Builla J, Bazan NG. A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis. European Journal of Medicinal Chemistry. 2020 202: 112600. PMID 32629335 DOI: 10.1016/j.ejmech.2020.112600
Nicolas G. Bazan and William C. Gordon, Learning from the Fly Photoreceptor on How Synapses Integrate Gene Expression to Sustain Retina and Brain Function, Neuron 101:548-550, 2019. https://doi.org/10.1016/j.neuron.2019.02.004
Gordon WC, López VG, Bhattacharjee S, Gil DR, Díaz JA, de la Losa FP, Peláez RP, Ferrer CT, Bacchini GS, Jun B, Varoqui H, Bazan NG. A nonsteriodal novel formulation targeting inflammatory and pruritus-related mediators modulates experimental allergic contact dermatitis Dermatol Ther (Heidelb).2018 Mar;8(1):111-126.
Jun, Bokkyoo, Mukherjee, Pranab K., Asatryan Aram, Kautzmann, Marie-Audrey, Heap, Jessica, Gordon, William C., Bhattacharjee, Surjyadipta, Yang, Rong, Petasis, Nicos A., Bazan, Nicolas G. Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity, Scientific Reports, 7:5279, 2017
Chapter
Retinal Degenerative Diseases 2016, Volume 854 of the series Advances in Experimental Medicine and Biology pp 385-391 Molecular Principles for Decoding Homeostasis Disruptions in the Retinal
Pigment Epithelium: Significance of Lipid Mediators to Retinal Degenerative Diseases
Hong, S.H. , Khoutorova, L., Bazan, N.G., and Belayev, L; Docosahexaenoic Acid Improves behavior and Attenuates Blood-Brain Barrier Injury Induced by Focal Cerebral Ischemia in Rats.Experimental and Tranlsational Stroke Medicine (2015) 7:3:1-10.
Rice, D.S. Calandria, J.M., Gordon, W.C., Jun, B.K., Zhou, Y.D., Gelfman, C.M., Li, S.H., Jin, M., Knott, E.J., Chang, B., Abuin, A., Issa El-Samman, T., Potter, D., Platt, K.A., and Bazan, N.G. Adiponectin Receptor 1 Conserves Docosahexaenoic Acid and Promotes Photoreceptor Cell Survival, Nature Communications, 2015 1-14.
Calandria, J.M., Asatryan, A., Balaszczuk, V., Knott, E.J., Jun, B.K., Mukherjee, P.K., Belayev, L., and Bazan, N.G. NPD1-Mediated Steroselective Regulation of BIRC3 Expression Through cREL is Decisive for Neural Cell Survival, 2015, Cell Death and Differentation, 1-15.
Eady, T.N., Khoutorova, L.,Obenaus, A., Mohd-Yusof, A., Bazan, N.G., Belayev, L. Docosahexaenoic Acid complexed to albumin provides neuroprotection after experimental stroke in aged rats; Neurobiology of Disease; 62:1-7, 2014.
Docosahexaenoic Acid and its derivative Neuroprotectin D1 Display Neuroprotective Properties in the Retina, Brain and Central Nervous System. Makrides M. Ochoa JB, Szajewska H (eds): The Importance of Immunonutrition. Nestlé Nutr Inst Workshop Ser, Vol 77, pp 121-131, (DOI: 10.1159/000351395) Nestec Ltd., Vevey/S.Karger AG., Basel, c 2013.
Erickson, J.D., Bazan, N.G. The Nucleolus Fine-tunes the Orchestration of an Early Neuroprotection Response in Neurodegeneration. Cell Death Differ. 2013.
Sheets, K.G., Jun, B., Zhou, Y., Zhu, M., Petasis, N.A., Gordon, W.C., Bazan, N.G. Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. Mol Vis.2013;19:1747-59.
Songhua Li, Jungsoo Lee, Yongdong Zhou, William C. Gordon, James M. Hill, Nicolas G. Bazan, Jeffrey H. Miner, and Minghao Jin. Fatty Acid Transport Protein 4 (FATP4) Prevents Light-Induced Degeneration of Cone and Rod Photoreceptors by Inhibiting RPE65 Isomerase; The Journal of Neuroscience, 2013, 3178:33(7):3178 –3189.
Lentz, J., Jodelka, F.M., Hinrick, A.J., McCaffrey, K.E., Farris, H.E., Spalitta, M.J., Bazan, N.G., Duelli, D.M., Rigo, F., Hastings, M.L. Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness; Nature Medicine Advance Published Online February 2013 1-8.
Eady, T.N., Khoutorova, L., Atkins, K.D., Bazan, N.G., Belayev, L. Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window. Exp Transl Stroke Med. 2012 Sep 14;4(1):19. doi: 10.1186/2040-7378-4-19.
Eady, T.N., Khoutorova, L., Atkins, K.D., Bazan, N.G., Belayev, L. Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window. Exp Transl Stroke Med. 2012 Sep 14;4(1):19. doi: 10.1186/2040-7378-4-19.
Bazan, N.G. Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. Mol Neurobiol. 2012 Aug;46(1):221-6. doi: 10.1007/s12035-012-8322-5. Epub 2012 Sep 7.
Petasis, N.A., Yang, R., Winkler, J.W., Zhu, M., Uddin, J., Bazan, N.G., Serhan, C.N. Stereocontrolled total synthesis of neuroprotectin D1 / protectin D1 and its aspirin-triggered stereoisomer. Tetrahedron Lett. 2012 Apr 4;53(14):1695-1698. Epub 2012 Jan 14.
Bazan, N.G., Eady, T.N., Khoutorova, L., Atkins, K.D., Hong S., Lu, Y., Zhang C., Jun, B., Obenaus A., Fredman, G., Zhu, M., Winkler, J.W., Petasis, N.A., Serhan, C.N., Belayev, L. Novel aspirin-triggered Neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. Exp Neurol. 2012 Jul; 236(1):122-30. Epub 2012 Apr 19.
Calandria, J.M., Mukherjee, P.K., Vaccari, J., Zhu, M., Petasis, N.A., Bazan, N.G. Ataxin-1 Poly-Q-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotection D1. J Biol Chem. 2012 Jul 6; 287(28):23726-39. Epub 2012 Apr 16.
Petasis, N.A., Yang, R., Winkler, J.W., Zhu, M., Uddin, J., Bazan, N.G., Serhan, C.N. Stereocontrolled total synthesis of Neuroprotectin D1/Protectin D1 and its aspirin-triggered stereoisomer, Tetrahedron Letters 2012 53:1695-1698.
Stark, D.T., Bazan, N.G. Synaptic and extrasynaptic NMDA receptors differentially modulate neuronal COX-2 function, lipid peroxidation, and neuroprotection. J Neurosci. 2011 31:13710-13721.
Zhou, Y., Sheets, K.G., Knott, E.J., Regan, C.E. Jr., Tuo, J., Chan, C.C., Gordon, W.C., Bazan, N.G.
Cellular and 3D Optical Coherence Tomography Assessment During the Initiation and Progression of Retinal Degeneration in the Ccl2/Cx3cr1-deficient Mouse. Exp. Eye Res. 2011 93:636-648.
Cortina, M.S., He, J., Li, N., Bazan, N.G., Bazan, H.E. Recovery of corneal sensitivity, CGRP positive nerves and increased wound healing are induced by PEDF plus DHA after experimental surgery. Arch. Ophthal. 2012 130:76-83; 2011 (online first).
Molina, M.F., Bazan, N.G. The bioactive mediator neuroprotectin D1 derived from docosahexaenoic acid is a homeostatic cell survival sentinel in the nervous system. ASBMB Today July 2011 pp.24-25.
Musto, A.E., Gjorstrup, P., Bazan, N.G. The omega-3 fatty acid-derived neuroprotectin D1 limits hippocampal hyperexcitability and seizure susceptibility in kindling epileptogenesis. Epilepsia. 2011 52:1601-1608.
Mattson, M.P., Bazan, N.G. Apoptosis and Necrosis. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Belayev, L., Lu, Y. M., Bazan, N.G. Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Halabi, A., Ertel, M., Petasis, N.A. Neuroinflammation. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Stark, D.T., Petasis, N.A. Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor. In Basic Neurochemistry: Molecular, Cellular and Medical Aspects, 8th edition, G.Siegel, R.W. Albers, S.T. Brady, D.L. Price (eds.), 2011.
Bazan, N.G., Molina, M.F., Gordon, W.C. Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's and other Neurodegenerative Diseases. Annual Review of Nutrition 2011 31:321-51.
Stark, D.T., Bazan, N.G. Protectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. Mol Neurobio, (2011) 2:131-8.
Kenchegowda, S., Bazan, N.G., Bazan, H. E. EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation.Invest Ophthalmol Vis Sci. (2011) 6:52:2240-9.
He, J., Kakazu, A.H., Bazan, N.G., Bazan, H.E. Aspirin-Triggered Lipoxin A4 (15-epi-LXA4) Increases the Endothelial Viability of Human Corneas Storage in Optisol-GS. J Ocul Pharmacol Ther. 2011 27:235-241.
Zhao, Y., Calon, F., Julien, C., Winkler, J.W., Petasis, N.A., Lukiw, W.J., Bazan, N.G. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. PLoS One. (2011) 6:e15816.
Belayev, L., Khoutorova, L., Atkins, K.D., Eady, T.N., Hong, S., Lu, Y., Obenaus, A., Bazan, N.G. Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke. Transl Stroke Res. (2011) 2:33-41.
Knott, E.J., Sheets, K.G., Zhou, Y., Gordon, W.C., Bazan, N.G. Spatial correlation of mouse photoreceptor-RPE thickness between SD-OCT and histology. Exp Eye Res. (2011) 92:155-60.
Lukiw, W.J., Bazan, N.G. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Mol Neurobiol. 2010 42:10-16
Bazan, N.G., Calandria, J.M., Serhan, C.N. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. (2010) 51:2018-31.
Halapin, N.A., Bazan, N.G. NPD1 induction of retinal pigment epithelial cell survival involves PI3K/Akt phosphorylation signaling. Neurochem Res. (2010) 35:1944-7.
Cui, J.G., Bazan, N.G. Agrin downregulation induced by nerve injury contributes to neuropathic pain. J. Neurosci. (2010) 30:15286-15297.
He, J., Bazan, N.G., Bazan, H.E. Mapping the entire human corneal nerve architecture. Exp Eye Res. (2010) 91:513-523.
Palacios-Pelaez, R., Lukiw, W.J., Bazan, N.G. Omega-3 essential Fatty acids modulate initiation and progression of neurodegenerative disease. Mol. Neurobiol. (2010) 41:367-374.
Lukiw, W.J., Bazan, N.G. Inflammatory, apoptotic, and survival gene signaling in Alzheimer's disease. A review on the bioactivity of neuroprotectin D1 and apoptosis.Mol. Neurobiol. (2010) 42:10-16.
Antony, R., Lukiw, W.J., Bazan, N.G. Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival. J. Biol. Chem. (2010) 285:18301-18308.
Faghiri, Z., Bazan, N.G. PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis. Exp. Eye Res. (2010) 90:718-725.
Sheets, K.G., Zhou, Y., Ertel, M.K., Knott, E. J., Regan, C. E., Elison, J.R., Gordon, W.C., Gjorstrup, P., N.G. Bazan. Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. Mol Vis. (2010) 16:320-329.
Marcheselli, V.L., Mukherjee, P.K., Arita, M., Hong, S., Antony, R., Sheets, K., Winkler, J.W., Petasis, N.A., Serhan, C.N., Bazan, N.G. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins Leukot Essent Fatty Acids. (2010) 82:27-34.
Calandria, J.M., Bazan, N.G. Neuroprotectin D1 Modulates the Induction of Pro-Inflammatory Signaling and Promotes Retinal Pigment Epithelial Cell Survival During Oxidative Stress. Adv Exp Med Biol. 664 (2010) 663-670. (Review)
Zhang, C., Bazan, N.G. Lipid-mediated cell signaling protects against injury and neurodegeneration. J Nutr. (2010) 140:858-863. (Review)
Niemoller, T.D., Bazan, N.G. Docosahexaenoic acid neurolipidomics. Prostaglandins Other Lipid Mediat. (2010) 91:85-89. (Review)
Cortina, M.S., He, J., Li, N., Bazan, N.G, Bazan, H.E. Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA. Invest Ophthalmol Vis Sci. (2010) 51:804-810.
Calandria, J.M., Bazan, N.G. Neuroprotectin D1 modulates the induction of pro-inflammatory signaling and promotes retinal pigment epithelial cell survival during oxidative stress. In: Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations. Advances in Experimental Medicine and Biology. Vol. 664. Eds: R. E. Anderson, J. G. Hollyfield, M. M. LaVail. (2010) Ch. 76:663-670.
Calandria, J.M., Marcheselli, V.L., Mukherjee, P.K., Uddin, J., Winkler, J.W., Petasis, N.A., Bazan, N.G. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J Biol Chem. (2009) 284:17877-17882.
Belayev, L., Khoutorova, L., Atkins, K.D., Bazan, N.G. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. Stroke. (2009) 40:3121-3126.
Belayev, L., Khoutorova, L., Atkins, K., Cherqui, A., Alvarez-Builla, J., Bazan, N.G. LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat. Brain Res. (2009) 1253:184-190.
Esquenazi, S., He, J., Li, N., Bazan, N.G, Esquenazi, I., Bazan, H.E. A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory mediators in mice exposed to desiccating conditions after PRK. Clin Dev Immunol. (2009) 2009:138513.
Bazan, N.G. Is NF-kappa B from astrocytes a decision maker of neuronal life or death? (Commentary on Dvoriantchikova et al.). Eur J Neurosci. (2009) 30:173-174. Commentary
Bazan, N.G.
Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection.
Prostaglandins Leukot Essent Fatty Acids. (2009) 81:205-211. (Review)
Niemoller, T.D., Stark, D.T., Bazan, N.G. Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system. World Rev Nutr Diet. (2009) 99:46-54. (Review)
Bazan, N.G. Neuroprotectin D1-mediated anti-inflammatory and survival signaling in stroke, retinal degenerations, and Alzheimer's disease. J Lipid Res. (2009) 50:Suppl:S400-S405. (Review)
Bazan, N.G. Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids. (2009) 81:205-211.
Bazan, N.G. Cell Signaling by Polyunsaturated Fatty Acids in Epileptogenesis. In: Philip A. Schwartzkroin, editor, Encyclopedia of Basic Epilepsy Research, Vol 2. Oxford: Academic Press; 2009. pp. 703-712.
Bazan, N.G., and Musto A.E. Inositol Lipid Signaling in Synaptic Activity, Neuronal Plasticity and Epileptogenesis. In: Philip A. Schwartzkroin, editor Encyclopedia of Basic Epilepsy Research, Vol 3. Oxford: Academic Press; 2009. pp. 1160-1166.
Belayev, L., Khoutorova, L., Atkins, K., Gordon, W.C., Alvarez-Builla, J., Bazan, N.G. LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. Exp Neurol. (2008) 214:253-258.
Lukiw, W.J., Bazan, N.G. Docosahexaenoic acid and the aging brain. J Nutr. (2008) 138:2510-2514. (Review)
Van Meter, K., Sheps, S., Kriedt, F., Moises, J., Barratt, D., Murphy-Lavoie, H., Harch, P.G., Bazan, N.G. Hyperbaric oxygen improves rate of return of spontaneous circulation after prolonged normothermic porcine cardiopulmonary arrest. Resuscitation (2008) 78:200-214.
Bazan, N.G. Neurotrophins induce neuroprotective signaling in the retinal pigment epithelial cell by activating the synthesis of the anti-inflammatory and anti-apoptotic neuroprotectin D1. Adv Exp Med Biol. (2008) 613:39-44.
Mukherjee, P.K., Marcheselli, V.L., Barreiro, S., Hu, J., Bok, D., Bazan, N.G. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. Proc Natl Acad Sci USA. (2007) 104:13152-13157.
Mukherjee, P.K., Marcheselli, V.L., de Rivero Vaccari, J.C., Gordon, W.C., Jackson. F.E., Bazan, N.G. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. Proc Natl Acad Sci USA. (2007) 104:13158-13163.
Mukherjee, P.K., Chawla, A., Loayza, M.S., Bazan, N.G. Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. Prostaglandins Leukot Essent Fatty Acids. (2007) 77:233-238.
Bazan, N.G. Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. Invest Ophthalmol Vis Sci. (2007) 48:4866-4881.
Ryan, S.D., Harris, C.S., Mo, F., Lee, H., Hou, S.T., Bazan, N.G, Haddad, P.S., Arnason, J.T., Bennettm, S.A. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. J Neurochem(2007) 103:88-97.
Esquenazi, S., He, J., Li, N., Bazan, N.G., Esquenazi, I., Bazan, H.E. Comparative in vivo high-resolution confocal microscopy of corneal epithelium, sub-basal nerves and stromal cells in mice with and without dry eye after photorefractive keratectomy. Clin Experiment Ophthalmol. (2007) 35:545-549.
Kolko, M., Prause, J.U., Bazan, N.G., Heegaard, S. Human secretory phospholipase A(2), group IB in normal eyes and in eye diseases, Acta Ophthalmol Scand. (2007) 85:317-323.Cui, J.G., Zhang, X., Zhao, Y.H., Chen, C., Bazan, N.G. Allodynia and hyperalgesia suppression by a novel analgesic in experimental neuropathic pain. Biochem Biophys Res Commun 350:358-363, 2006. Erratum in: Biochem Biophys Res Commun. (2007) 359:187-188.
Vaccarino, A.L., Paul, D., Mukherjee, P.K., Rodríguez de Turco, E.B., Marcheselli, V.L., Xu, L., Trudell, M.L., Minguez, J.M., Matía, M.P., Sunkel, C., Alvarez-Builla, J., Bazan, N.G. Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs. Bioorg Med Chem. (2007) 15:2206-2215.
Kolko, M., Wang, J., Zhan, C., Poulsen, K.A., Prause, J.U., Nissen, M.H., Heegaard, S., Bazan, N.G. Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci. (2007) 48:1401-1409.
Bazan, N.G. Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. Curr Opin Clin Nutr Metab Care. (2007) 10:136-141.
Bazan, N.G. Survival signaling in retinal pigment epithelial cells in response to oxidative stress: significance in retinal degenerations. Adv Exp Med Biol. (2006) 572:531-540.
Lukiw, W.J., Bazan, N.G. Survival signalling in Alzheimer's disease. Biochem Soc Trans. (2006) 34:1277-1282.
Cole-Edwards, K.K., Musto, A.E., Bazan, N.G. c-Jun N-terminal kinase activation responses induced by hippocampal kindling are mediated by reactive astrocytes. J Neurosci(2006) 26:8295-8304.
Bazan, N.G. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Cell Mol Neurobiol. (2006) 26:901-913.
Lukiw, W.J., Mukherjee, P.K., Cui, J.G., Bazan, N.G. A2E selectively induces COX-2 in ARPE-19 and human neural cells. Curr Eye Res. (2006) 31:259-263.
Kolko, M., Christoffersen, N.R., Barreiro, S.G., Miller, M.L., Pizza, A.J., Bazan, N.G. Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. J Neurosci Res. (2006) 83:874-882.
Musto, A., Bazan, N.G. Diacylglycerol kinase epsilon modulates rapid kindling epileptogenesis. Epilepsia. (2006) 47:267-276.
He J., Bazan N.G., Bazan H.E. Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol. (2006) 124:70-78.
Faghiri, Z., Bazan, N.G. Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium. Invest Ophthalmol Vis Sci. (2006) 47:397-404.
Esquenazi, S., He, J., Kim, D.B., Bazan, N.G., Bui, V., Bazan, H.E. Wound-healing response and refractive regression after conductive keratoplasty. J Cataract Refract Surg. 32:480-486, 2006.
Chen, C., Hardy, M., Zhang, J., LaHoste, G.J., Bazan, N.G. Altered NMDA receptor trafficking contributes to sleep deprivation-induced hippocampal synaptic and cognitive impairments. Biochem Biophys Res Commun. (2006) 10;340:435-440.
McDermott, C.M., Hardy, M.N., Bazan, N.G., Magee, J.C. Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus. J Physiol. (2006) 1;570:553-65.
Malcher-Lopes, R., Di, S., Marcheselli, V.S., Weng, F.J., Stuart, C.T., Bazan, N.G., Tasker J.G. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci. (2006) 26:6643-6650.
Ruskin, D.N., Dunn, K.E., Billiot, I., Bazan, N.G., Lahoste, G.J. Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze. Life Sci. (2006) 78:2833-2838.
Esquenazi, S., He, J., Bazan, H.E., Bazan, N.G. Use of autologous serum in corneal epithelial defects post-lamellar surgery. Cornea. (2005) 24:992-997.
Cole-Edwards, K.K., Bazan, N.G. Lipid signaling in experimental epilepsy. Neurochem Res. (2005) 847-853 (Review).
Tian, X., Bazan, N.G. Neuroprotection by platelet-activating factor antagonism. Ann N Y Acad Sci. (2005) 1053:455-456 (Review).
Kolko, M., Christoffersen, N.R., Varoqui, H., Bazan, N.G. Expression and induction of secretory phospholipase A2 group IB in brain. Cell Mol Neurobiol. (2005) 25:1107-1122.
Lukiw, W.J., Pappolla, M., Pelaez, R.P., Bazan, N.G. Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism. Cell Mol Neurobiol(2005) 25:475-483 (Review).
Chen, C., Bazan, N.G. Endogenous PGE 2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol(2005) 93:929-941.
Mattson, M.P., Bazan, N.G. Apoptosis and necrosis., Basic Neurochemistry 7 th edition, G. Siegel, R. W. Albers, S. T. Brady, D. L. Price (eds.), (2005).
Zhu, P., Genc, A., Zhang, X., Zhang, J., Bazan, N.G, Chen, C. Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors. J Neurosci Res (2005) 15;81:817-826.
Bazan, N.G. Synaptic signaling by lipids in the life and death of neurons. Mol Neurobiol (2005) 31:219-230 (Review).
Bazan, N.G.Neuroprotectin D1 (NPD1): A DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol (2005) 15:159-166 (Review).
Bazan, N.G., Marcheselli, V.L., Cole-Edwards, K. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci. (2005) 1053:137-147 (Review).
Chen, C., Bazan, N.G.Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid. Mediat. (2005) 77:65-76 (Review).
Bazan, N.G.Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol. (2005) 32:89-103 (Review).
Sang, N., Zhang, J., Marcheselli, V.L., Bazan, N.G., Chen, C. Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. J Neurosci. (2005) 26;25:9858-9870.
Di, S., Boudaba, C., Popescu, I.R., Weng, F.J., Harris, C., Marcheselli, V.L., Bazan, N.G., Tasker, J.G. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol. (2005) 5;569:751-760.
Lukiw, W.J., Cui, J.G., Musto, A.E., Musto, B.C., Bazan, N.G.Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun. (2005) 9;338:77-81.
Esquenazi, S., He, J., Bazan, N.G., Bazan, H.E. Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy. J Cataract Refract Surg. (2005) 31:1632-1639.
Esquenazi, S., Bazan, H.E., Bui, V., He, J., Kim, D.B., Bazan, N.G.Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. Invest Ophthalmol Vis Sci. (2005) 46:3121-3127.
Di, S., Malcher-Lopes, R., Marcheselli, V.L., Bazan, N.G., Chen, C. Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology. (2005) 146:4292-4301.
Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G.Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res (2005) 81:742-750.
Teather, L.A., Packard, M.G., Smith, D.E., Ellis-Behnke, R.G., Bazan, N.G.Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks. Neurobiol Learn Mem(2005) 84:75-84.
Boedker, M., Boetkjaer, A., Bazan, N.G., Cui, J.G., Zhao, Y., Pelaez, R.P., Lukiw, W.J. Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. Neurosci Lett (2005) 20-27;380:176-180.
Sharma, G.D., Ottino, P., Bazan, N.G., Bazan, H.E. Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J Biol Chem (2005) 4;280:7917-7924.
Lukiw, W.,Cui, J.G., Marcheselli, V., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., Bazan, N.G. A role for docosahexaenoic acid-derived neuroprotection D1 in neural cell survival and Alzheimer’s disease. J Clin Inv.(2005) 115:2774-2783.
Belayev, L., Marcheselli, V.L., Khoutorova, L., Rodriguez de Turco, E.B., Busto, R., Ginsberg, M.D., Bazan, N.G.Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke (2005) 36:118-123.
Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G.Neuroprotectin D1: A docosahexanoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci, USA (2004) 101:8491-8496.
Ottino, P., Finley, J., Rojo, E., Ottlecz, A., Lambrou, G.N., Bazan, H.E., Bazan, N.G. Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells. Involvement of cytosolic phospholipase A(2) activity. Mol Vis(2004) 10:341-350.
Zhu, P., DeCoster, M.A., Bazan, N.G. Interplay among platelet-activating factor, oxidative stress, and group I metabotropic, glutamate receptors modulates neuronal survival. J Neurosci Res (2004) 77:525-531.
Cui, J.G., Kuroda, H., Chandrasekharan, N.V., Pelaez, R.P., Simmons, D.L., Bazan, N.G., Lukiw, W. J. Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem Res(2004) 29:1731-1737.
Rollin, S., Lemieux, C., Maliba, R., Favier, J., Villeneuve, L.R., Allen, B.G., Soker, S., Bazan, N.G., Merhi, Y., Sirois, M.G. VEGF-mediated endothelial P-selectin translocation: Role of VEGF receptors and endogenous PAF synthesis. Blood (2004) 103:3789-3797.
Axelrad, T.W., Deo, D.D., Ottino, P., Van Kirki, J., Bazan, N.G., Bazan, H.E.P., Hunt, J.D. Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration.FASEB J (2004) 18:568-570.
Deo, D.D., Bazan, N.G., Hunt, J.D. Activation of platelet-activating factor (PAF) receptor-coupled Ga q leads to stimulation of Src and focal adhesion kinase (FAK) via two separate pathways in human umbilical vein endothelial cells (HUVEC). J Biol Chem 279:3497-3508, 2004.
Ma, X., Ottino, P., Bazan, H.E., Bazan, N.G. Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. Invest Ophthalmol Vis Sci. (2004)45:2915-2921.
Kolko, M., Christoffersen, N.R., Barreiro, S.G., Bazan, N.G.Expression and location of mRNAs encoding multiple forms of secretory phospholipase A 2 in the rat retina. J Neurosci Res (2004) 77:517-524.
Katsura, K., Rodriguez de Turco, E.B., Siesjö, B.K., Bazan, N.G. Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. Brain Res (2004) 1030:133-140.
Tu, B., Bazan, N.G. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenases-2 expression in neocortex. Exp. Neurol. (2003) 179:167-175.
Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G. DNA repair in photoreceptor survival. Mol Neurobiol (2003) 28:111-122 (Review).
McDermott, C., LaHoste, G.J., Chen, C., Musto, A., Bazan, N.G., Magee, J.C. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci(2003) 23:9687-9695.
Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronert, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G. Novel docosanoids inhibit brain ischema-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem (2003) 278:43807-43817.
Bazan, N.G. Synaptic lipid signaling: Significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res (2003) 44:2221-2233.
Lukiw, W.J., Ottlecz, A., Lambrou, G., Grueninger, M., Finley, J., Thompson, H.W., Bazan, N.G. Coordinate activation of HIF-1 and NF-KappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investi Ophthalmol and Vis Sci (2003) 44:4163-4170.
Chen, C., Bazan, N.G.Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT 2 receptor. NeuroReport (2003) 14:743-747.
Kolko, M., Rodriguez de Turco, E.B., Diemer, N.H., Bazan, N.G. Neuronal damage by secretory phospholipase A2: Modulation of cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. Neurosci Lett(2003) 338:164-168.
Bazan, N.G. and Flower, R.J. Lipid signals in pain control. Nature (2002) 420:135-138. (News and Views).
Bazan, N.G. and Lukiw, W.J. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1 beta and amyloid-beta 42 peptide is potentiated by hypoxia in primary human neural cells. J Biol Chem (2002) 277:30359-30367.
Gordon, W.C., Casey, D.M., Lukiw, W.J., Bazan, N.G. DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci (2002) 43:3511-3521.
Rodriguez de Turco, E.B., Belayev, L., Liu, Y., Busto, R., Parkins, N., Bazan, N.G., Ginsberg, M.D. Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin. J Neurochem(2002) 82:1-10.
DeCoster, M.A., Lambeau, G., Lazdunski, M., Bazan, N.G. Secreted phospholipase A 2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J Neurosci Res (2002) 67:634-645.
Rodriguez de Turco, E.B., Jackson, F.R., DeCoster, M.A., Kolko, M., Bazan, N.G. Glutatmate signaling and secretory phospholipase A 2 modulate the release of arachidonic acid from neuronal membrane.J Neurosi Res (2002) 68:558-567.
Teather, L.A., Packard, M.A., Bazan, N.G. Post-training cyclooxygenase-2 (COX) inhibition impairs memory consolidation. Learning and Memory (2002) 9:41-47.
Deo, D.D., Axelrad, T.W., Robert, E.G., Marcheselli, V.L., Bazan, N.G, Hunt, J.D. Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells: Evidence for a dual kinase mechanism. J Biol Chem (2002) 277:21237-21245.
Parker, M.A., Bazan, H.E.P., Marcheselli, V.L., Rodriguez de Turco, E.B., Bazan, N.G. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J Neurosci Res (2002) 68:39-50.
Chen, C., Magee, J.C., Bazan, N.G. Cyclooxygenase-2 regulates prostaglandin E 2 signaling in hippocampal long- term synaptic plasticity. J Neurophysiol (2002) 87:2851-2857.
Kolko, M., Nielsen, M., Bazan, N.G., Diemer, N. Secretory phospholipase A 2 induces delayed neuronal COX-2 expression as compared to glutamate. J Neurosci Res (2002) 69:169-177.
Bazan, N.G., Tu, B., Rodriguez de Turco, E.B. What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. Prog Brain Res(2002) 135:175-185, (Review).
Rodriguez de Turco, E.B., Tan, W., Tophan, M.K., Sakane, F., Marcheselli, V.L., Chen, C., Taketomi, A., Prescott, S., Bazan, N.G. Diacylglycerol kinase epsilon regulates seizures susceptibility and long term potentiation through inositol lipid signaling. Proc Natl Acad Sci(2001) 98:4740-4745.
Bazan, N.G.COX-2 as a multifunctional neuronal modulator. Nature Medicine(2001) 7:414-415, (News and Views).
Chen, C., Magee, J.C., Marcheselli, V.L., Hardy, M., Bazan, N.G. Attenuated long-term potentiation in hippocampal dentate gyrus neurons of mice deficient in the platelet-activating factor receptor. J Neurophysiol(2001) 85:384-390.
Lukiw, W.J., Carver, L.A., LeBlanc, H.J., Bazan, N.G. Analysis of 1184 gene transcript levels in Alzheimer CA1 hippocampus: synaptic signaling and transcription factor deficits and upregulation of pro-inflammatory pathways. Alzheimer’s Reports (2000) 3:143-149.
Lukiw, W.J., Rogaev, E.I., Bazan, N.G. Potential of transcriptional coordination of nine genes associated with Alzheimer’s disease. Alzheimer’s Reports(2000) 3:231-242.
Ershov, A.V., Bazan, N.G. Photoreceptor phagocytosis selectively activates PPARa expression in retinal pigment epithelial cells. J Neurosci Res (2000) 60:328-337.
Bazan, N.G. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochem. Biophys. Acta 218:1-10, 1970. Selected as "This Week's Citation Classic" (1991).
PDF with links for Dr. Bazan's publications 1963 to 2012
Funding:
“Neuroprotection: Lipid Signaling in Ischemia-Reperfusion”
Principal Investigator:
Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institute for Neurological Disorders and Stroke,
National Institutes of Health (R01 NS046741)
Period: 07/01/10-06/30/15
"Molecular Logic of Neuronal Adaption for Survival"
Principal Investigator: Nicolas G. Bazan, M.D., Ph.D.
Grant: 2011 National Institutes of Health Directors Pioneer Award
Funding Agency: National Institutes of Health
Period: Pending
"Neuroprotective Bioactivity of Neuroprotectin D1 with Nanoparticle-Enhanced Delivery in Experimental Retinal Degeneration"
Principal Investigator:
Nicolas G. Bazan, M.D., Ph.D.
Agency: Beckman Initiative for Macular Research; The Arnold and Mabel Beckman Foundation, Doheny Eye Institute (1101)
Period: 07/01/10-06/30/12
“Mentoring Neuroscience in Louisiana: A Biomedical Program to Enhance Neuroscience”
Principal Investigator: Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institutes of Health, National Center for Research Resources (P20 RR016816)
Period: 02/01/07-01/31/12
“NPD1 promotes survival signaling in the Ccl2-/-/Cx3cr1-/- mouse AMD model”
Principal Investigator:
Nicolas G. Bazan, M.D., Ph.D.
Agency: American Health Assistance Foundation
Period: 04/01/10-03/31/12
“Mechanism of action of omega-3 fatty acids in brain injury”
Principal Investigators:
Nicolas G. Bazan, M.D., Ph.D. (LSUHSC)
Charles N. Serhan, Ph.D. (Harvard)
Nicos A. Petasis, Ph.D. (USC)
Agency: National Institutes of Health, National Center for Complementary and Alternative Medicine (RC2 AT005909)
Period: 09/30/09-09/29/11
“Neuroprotectin D1 slows photoreceptor degeneration”
Principal Investigator:
Nicolas G. Bazan, M.D., Ph.D.
Agency: Foundation Fighting Blindness (TA-NP-0808-0463-LSUNO)
Period: 08/01/08-07/31/11
“RPE Messengers, Transcription and Photoreceptor Renewal”
Principal Investigator:
Nicolas G. Bazan, M.D., Ph.D.
Agency: National Institutes of Health, National Eye Institute (R01 EY005121)
Period: Pending
The Oxygen Revolution with Dr. Harch and Dr. Bazan
- YouTube 082311 http://www.youtube.com/watch?v=_gEsvynIk1g
CIHR Training Program in Neurodegenerative Lipidomics: Ask me about Lipidomics
-
Dr. Nicolas Bazan - 110809 http://www.youtube.com/watch?v=BM-Me2ediXA
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