Boyd Professor
Ernest C. and Yvette C. Villere Chair
for the Study of Retinal Degeneration

Professor of Ophthalmology, Biochemistry and
Molecular Biology, and Neurology

Director, Neuroscience Center of Excellence

Gravier Street Suite D
New Orleans, LA 70112
Phone: (504) 599-0831 or (504) 599-0832
Fax: (504) 599-0831 or(504) 599-0832
nbazan@lsuhsc.edu

Dr. Hamilton Farris, Mette Flatt, Dr. William Gordon, Dr. Jennifer Lentz,
and Dr. Nicolas Bazan (the research team)
Local medical research team makes breakthrough in curing deafness
link to page  Meg Farris, WWWLTV.com, February 4, 2013.

Balanced Body and Brain: A FOX 8 special report
Link to interview

Researchers in Town to Share Discoveries on Brain Injuries SFN Convention 2012
Link to interview with Dr. Bazan and other Neuroscientists  WWL-TV

Study: Smoking during pregnancy could lead to child's weight, drug issues
Fish Oil/WWL-TV

The Arts of Neuroscientists: Nicolas Bazan - Dana Foundation
The Dana Alliance for Brain Initiatives, a nonprofit organization of more than 300 leading neuroscientists, works to advance public awareness about the progress ...www.dana.org/news/features/detail.aspx?id=39684

New Study Backs Up Benefits of Fish Oil Supplements Meg Farris/WWL-TV 091212 
http://www.wwltv.com/news/health/New-study-backs-up-benefits-of-fish-oil-supplements-169549976.html

DHA: A Sentinel for Neuroprotection and Brain Repair
Global Organization for EPA and DHA (GOED) Exchange June 8, 2012
Early History of Omega-3 Research, Boston, Massachusetts

Protect your vision by altering your diet: Molly Kimball, The Times Picayune, 031612
http://www.nola.com/health/index.ssf/2012/03/protect_your_vision_by_alterin.html

Dr. Isabel Univision National Radio Show – 2/29/12-
Listen by clicking here: http://www.miunicast.com/Public/Media/DraIsabel-2012.02.29.mp3

Turn On Your Inner Light Radio Show – 2/21/12- Listen by clicking here:
http://www.youtube.com/watch?v=fn8eYfYTFdY

Steve Gleason's plight focuses attention on ALS – 092611
http://www.wwltv.com/news/health/Gleasons-plight-focuses-attention-on-ALS-130601058.html

A new discovery could reverse the effects of a stroke - 061711
http://www.wptv.com/dpp/news/health/medical_breakthroughs/a-new-discovery-could-reverse-the-effects-of-a-stroke

Stopping Stroke Damage with a Shot - 061511
http://abclocal.go.com/kfsn/story?section=news/health/health_watch&id=8193079

Ground breaks on new teaching hospital – 041811
http://www.wwltv.com/home/Ground-breaks-on-new-teaching-hospital-120140924.html

Featured videos - 111010
Medical watch: for some could tanning be an addiction?
New discovery from a local doctor that may help people suffering from a stroke
http://www.wwltv.com/news/health/Medical-Watch-For-some-could-tanning-be-an-addiction-107549033.html

Omega 3 fatty acids may help prevent Alzheimer's – 091610
http://www.wwltv.com/home/Omega-3-fatty-acids-may-help-prevent-Alzheimers-103105454.html

Impact of brain disease on families – 012209
http://www.wwltv.com/archive/65592787.html

Audio Interview with Dr. Nicolas Bazan – 060509
http://neworleanspodcasting.com/NicolasBazan.shtml

1965: M.D. - Medical School, U. Tucuman, Argentina

1966-1968: Research Thesis Work - Harvard Medical School (1970: Ph.D. - Medical School, U. Tucuman, Argentina)

2010 Bazan Awarded International Gradle Medal
Bazan Awarded International Gradle Medal. Dr Nicolas Bazan Nicolas G. Bazan, MD, PhD,
Professor and Director of the Neuroscience Center of Excellence at LSU Health

LSU professor gets medal for teaching
Bazan awarded Gradle Medal/Baton Rouge Advocate, February 21, 2016

Business Honors
Dr. Nicolas G. Bazan , professor and director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, has been presented the 2016 Gradle Medal for Teaching by the Pan-American Association of Ophthalmology. Baton Rouge Advocate, February 21, 2016

ANA Onsite Program Addendum October 15, 2013
The Art of Science
The Constellation of Events at the Onset of Dementia: An Artistic Perspective
Una Vida: A Fable of Music and the Mind

The Medal Professor Miroslaw M. Mossakowski Award to Nicolas G. Bazan, M.D., Ph.D.
October 2013 in Warsaw, Poland
Dr. Nicolas Bazan honored at ISN and ASN conference in Cancun, Mexico held April 17-19, 2013
Research to Prevent Blindness, Incorporated, NYInternational Research Scholar, Research to Prevent Blindness, Incorporated, NY,
1977 William & Mary Greve International Scholar,
1983-84 Elected to Council ISN,
1979‑83 Elected to Council ASN,
1988‑90 Gold Medal, Fondazione Giovanni Lorenzini, Milan, Italy,
1981 Honorary Professor, Universidad de Tucuman, Argentina,
1987‑Javits Neuroscience Award NINDS, 1989‑1996Citation Classic, Current Content/ Life Sciences 30:10(July 29),
1991 Elected Member, Academy of Medical Sciences, Cordoba, Argentina,
1991-Merck Lecture in Pharmacology, McGill University, Canada,
1992 Elected Member, Royal Academy of Sciences, Spain,
1993, 1996 11th William Harvey Lecture, London,
1994 Role Model Awardee, Young Leadership Council of New Orleans,
1994 Caputto Gold Medal, Argentine Neurochemical Society,
1994 Boyd Professor, Louisiana State University Medical Center,
1994 Welcome Professorship and Lecture (Burroughs Welcome Fund/FASEB) at University of North Carolina,
1996 Merit Award, Distinguished Argentine Abroad, National Research Council of Argentina, Presented by the President of Argentina,
1996 Annual John Dorsey Lecture, Wayne State University, Detroit, Michigan,
1996 Guest of Honor, Inaugural Symposium, Frontiers in Neuroscience, Wallenberg Neuroscience Center, Lund University, Sweden,
1996 William H. Bell Lectureship, Oklahoma Medical Research Foundation, Oklahoma City, OK,
1997 Robert Schwab Lecturer, 13th Ann. American Academy of Clinical Neurophysiology,
1998 Mayerson-Di Luzio Lecture, Tulane University School of Medicine, Dept. Physiology,
1998 Loris & David Rich Lecture in Visual Science, University of Alabama, Birmingham, AL,
1999 President, American Society for Neurochemistry,
1999-2001 Elected Fellow, Medical Society of Ireland, The Royal College of Physicians of Ireland, Dublin,
1999-Doctor Honoris Causa, Universidad de Nacional de Tucuman, Argentina,
1999 Endre A. Balazs Prize, International Society of Eye Research
2000 Citybusiness
2002 Innovator of the Year Award New Orleans, LA, 2002The Alzheimer’s Association Greater New Orleans Chapter Award, NOLA,
2002 Career Service Awards, 20 years, LSUHSC, NOLA,
2003 Family Services of Greater New Orleans (Ten Outstanding Persons) Award,
2003 First Leon S. Wolfe Lecture, Montreal Neurological Institute, Montreal, Canada,
2003 Association for Research in Vision and Ophthalmology, Proctor Medal and Lecture (highest honor of this Association),
2007 Association for Research in Vision and Ophthalmology Fellow, 2009Chevreul Medal, Paris, France,
2011 Translational Research Initiative in Ophthalmology (TRIO)
2012 Program PDF2nd Annual Gladstone/DZNE Workshop
2012 Program PDFGOED Exchange
2012 Program PDF.

Journal of Neurochemistry,
1981‑1989 Journal of Lipid Mediators,
1988‑1993 Journal of Cerebral Blood Flow and Metabolism,
1988‑1996 Molecular Neurobiology (Editor-in-Chief and Founder),
1987‑ Journal of Molecular Neuroscience,
1989‑1990 Journal of Nutritional Biochemistry,
1990‑2001 Journal of Clinical Neuroscience,
1993-1999 Receptors and Signal Transduction,
1996-1998 Journal of Biological Chemistry,
1997-2002 Proc Soc Exp Biol & Med,
2000-2004 Current Neurovascular Research,
2004- Handbook of Neurochemistry and Molecular Neurobiology, 3rd Edition, At Large Editor,
2005- Cell Death & Differentiation (Nature journal),
2007- Journal of Neurodegeneration and Regeneration,
2008- Cell Death & Disease (Nature journal), 2010

Current Research

A major goal of the N. Bazan laboratory is to understand the principles underlying endogenous responses of the central nervous system to injury and neurodegeneration. For this purpose, a convergence of approaches, including cellular and molecular, are used, complemented by cell cultures (e.g. hippocampal neurons) and experimental models of neurological (epilepsy, stroke, Alzheimer’s disease) and retinal diseases (age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy). His laboratory is interested in the significance of the selective enrichment in omega-3 essential fatty acids (docosahexaenoyl–DHA–chains of membrane phospholipids, 22C and 6 double bonds) in the nervous system (e.g. photoreceptors, synaptic membranes).

While studying mechanisms of cell survival in neurodegenerations, he and his colleagues discovered a docosanoid synthesized from DHA by a 15-lipoxygenase, which was named neuroprotectin D1 – (NPD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,-13E,15E,19Z hexaenoic acid).

This mediator is a docosanoid because it is derived from a 22C precursor (DHA), unlike eicosanoids, which are derived from the 20C arachidonic acid family member of essential fatty acids not enriched in the nervous system. NPD1 is promptly made in response to oxidative stress and brain ischemia-reperfusion, and in the presence of neurotrophins. NPD1 is neuroprotective in experimental stroke, oxidative-stressed retinal pigment epithelial (RPE) cells, and in human brain cells exposed to amyloid-β peptide. Thus NPD1 is a protective sentinel, one of the very first defenses activated when cell homeostasis is threatened by neurodegenerations.

Recent studies highlight the specificity and potency of NPD1 spanning beneficial bioactivity during initiation and early progression of neurodegenerations:

1) Photoreceptors renew membrane disks containing the phototransduction apparatus and DHA intermittently via shedding of their tips and phagocytosis by retinal pigment epithelial (RPE) cells. At the same time, new membrane disks are made at the base of the outer segments; their length remains constant and cell integrity is maintained remarkably unchanged throughout many decades. This outcome occurs in spite of the fact that the photoreceptors are in an oxidative stress-prone environment (light, high O2 consumption, high polyunsaturated fatty acid fluxes, etc).

He and his colleagues show that phagocytosis of photoreceptor disks promotes via NPD1 synthesis specific refractoriness to oxidative stress-induced apoptosis in RPE cells, which in turn fosters homeostatic photoreceptor cell integrity. Disruptions of the sentinel role of NPD1 in photoreceptor renewal may participate in macular degeneration and other retinal degenerations leading to blindness.

Dr. Nicolas G. Bazan with Dr. Amanda Henne

Rice, D.S. Calandria, J.M., Gordon, W.C., Jun, B.K., Zhou, Y.D., Gelfman, C.M., Li, S.H., Jin, M., Knott, E.J., Chang, B., Abuin, A., Issa El-Samman, T., Potter, D., Platt, K.A., and Bazan, N.G. Adiponectin Receptor 1 Conserves Docosahexaenoic Acid and Promotes Photoreceptor Cell Survival, Nature Communications, 2015 1-14.

Calandria, J.M., Asatryan, A., Balaszczuk, V., Knott, E.J., Jun, B.K., Mukherjee, P.K., Belayev, L., and Bazan, N.G. NPD1-Mediated Steroselective Regulation of BIRC3 Expression Through cREL is Decisive for Neural Cell Survival, 2015, Cell Death and Differentation, 1-15.

Eady, T.N., Khoutorova, L.,Obenaus, A., Mohd-Yusof, A., Bazan, N.G., Belayev, L. Docosahexaenoic Acid complexed to albumin provides neuroprotection after experimental stroke in aged rats;Neurobiology of Disease; 62:1-7, 2014.

Cortina, M.S., He, J.,  Li, N., Bazan, N.G, Bazan, H.E. Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA. Invest Ophthalmol Vis Sci. (2010) 51:804-810.

Calandria, J.M.,  Bazan, N.G. Neuroprotectin D1 modulates the induction of pro-inflammatory signaling and promotes retinal pigment epithelial cell survival during oxidative stress. In: Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations. Advances in Experimental Medicine and Biology. Vol. 664. Eds: R. E. Anderson, J. G. Hollyfield, M. M. LaVail. (2010) Ch. 76:663-670.

Calandria, J.M.,  Marcheselli, V.L., Mukherjee, P.K.,  Uddin, J., Winkler, J.W.,  Petasis, N.A.,  Bazan, N.G. Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. J Biol Chem. (2009) 284:17877-17882.

Belayev, L., Khoutorova, L., Atkins, K.D., Bazan, N.G. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia.  Stroke. (2009) 40:3121-3126.

Belayev, L.,  Khoutorova, L.,  Atkins, K.,  Cherqui, A.,  Alvarez-Builla, J.,  Bazan, N.G. LAU-0901, a novel platelet-activating factor receptor antagonist, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat. Brain Res. (2009) 1253:184-190.

Esquenazi, S.,  He, J., Li, N., Bazan, N.G, Esquenazi, I.,  Bazan, H.E. A novel platelet activating factor receptor antagonist reduces cell infiltration and expression of inflammatory mediators in mice exposed to desiccating conditions after PRK.  Clin Dev Immunol. (2009) 2009:138513.

Bazan, N.G. Is NF-kappa B from astrocytes a decision maker of neuronal life or death? (Commentary on Dvoriantchikova et al.). Eur J Neurosci.  (2009) 30:173-174. Commentary

Esquenazi, S., He, J., Bazan, H.E., Bazan, N.G. Use of autologous serum in corneal epithelial defects post-lamellar surgery. Cornea. (2005) 24:992-997.

Cole-Edwards, K.K., Bazan, N.G. Lipid signaling in experimental epilepsy. Neurochem Res. (2005) 847-853 (Review).

Tian, X., Bazan, N.G. Neuroprotection by platelet-activating factor antagonism. Ann N Y Acad Sci. (2005) 1053:455-456 (Review).

Kolko, M., Christoffersen, N.R., Varoqui, H., Bazan, N.G. Expression and induction of secretory phospholipase A2 group IB in brain. Cell Mol Neurobiol. (2005) 25:1107-1122.

Lukiw, W.J., Pappolla, M., Pelaez, R.P., Bazan, N.G. Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism. Cell Mol Neurobiol(2005) 25:475-483 (Review).

Chen, C., Bazan, N.G. Endogenous PGE 2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol(2005) 93:929-941.

Mattson, M.P., Bazan, N.G. Apoptosis and necrosis., Basic Neurochemistry 7 th edition, G. Siegel, R. W. Albers, S. T. Brady, D. L. Price (eds.), (2005).

Zhu, P., Genc, A., Zhang, X., Zhang, J., Bazan, N.G, Chen, C. Heterogeneous expression and regulation of hippocampal prostaglandin E2 receptors. J Neurosci Res (2005) 15;81:817-826.

Bazan, N.G. Synaptic signaling by lipids in the life and death of neurons. Mol Neurobiol(2005) 31:219-230 (Review).

Bazan, N.G.Neuroprotectin D1 (NPD1): A DHA-derived mediator that protects brain and retina against cell injury-induced oxidative stress. Brain Pathol(2005) 15:159-166 (Review).

Bazan, N.G., Marcheselli, V.L., Cole-Edwards, K. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci. (2005) 1053:137-147 (Review).

Chen, C., Bazan, N.G.Lipid signaling: sleep, synaptic plasticity, and neuroprotection. Prostaglandins Other Lipid. Mediat. (2005) 77:65-76 (Review).

Bazan, N.G.Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol Neurobiol. (2005) 32:89-103 (Review).

Sang, N., Zhang, J., Marcheselli, V.L., Bazan, N.G., Chen, C. Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. J Neurosci. (2005) 26;25:9858-9870.

Di, S., Boudaba, C., Popescu, I.R., Weng, F.J., Harris, C., Marcheselli, V.L., Bazan, N.G., Tasker, J.G. Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus. J Physiol. (2005) 5;569:751-760.

Lukiw, W.J., Cui, J.G., Musto, A.E., Musto, B.C., Bazan, N.G.Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Biochem Biophys Res Commun. (2005) 9;338:77-81.

Esquenazi, S., He, J., Bazan, N.G., Bazan, H.E. Comparison of corneal wound-healing response in photorefractive keratectomy and laser-assisted subepithelial keratectomy. J Cataract Refract Surg. (2005) 31:1632-1639.

Esquenazi, S., Bazan, H.E., Bui, V., He, J., Kim, D.B., Bazan, N.G.Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. Invest Ophthalmol Vis Sci. (2005) 46:3121-3127.

Di, S., Malcher-Lopes, R., Marcheselli, V.L., Bazan, N.G., Chen, C. Rapid glucocorticoid-mediated endocannabinoid release and opposing regulation of glutamate and gamma-aminobutyric acid inputs to hypothalamic magnocellular neurons. Endocrinology. (2005) 146:4292-4301.

Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G.Oxidative stress-induced retinal damage up-regulates DNA polymerase gamma and 8-oxoguanine-DNA-glycosylase in photoreceptor synaptic mitochondria. Exp Eye Res(2005) 81:742-750.

Teather, L.A., Packard, M.G., Smith, D.E., Ellis-Behnke, R.G., Bazan, N.G.Differential induction of c-Jun and Fos-like proteins in rat hippocampus and dorsal striatum after training in two water maze tasks. Neurobiol Learn Mem(2005) 84:75-84.

Boedker, M., Boetkjaer, A., Bazan, N.G., Cui, J.G., Zhao, Y., Pelaez, R.P., Lukiw, W.J. Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells. Neurosci Lett (2005) 20-27;380:176-180.

Sharma, G.D., Ottino, P., Bazan, N.G., Bazan, H.E. Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis. J Biol Chem(2005) 4;280:7917-7924.

Lukiw, W.,Cui, J.G., Marcheselli, V., Bodker, M., Botkjaer, A., Gotlinger, K., Serhan, C.N., Bazan, N.G.A role for docosahexaenoic acid-derived neuroprotection D1 in neural cell survival and Alzheimer’s disease. J Clin Inv. (2005) 115:2774-2783.

Belayev, L., Marcheselli, V.L., Khoutorova, L., Rodriguez de Turco, E.B., Busto, R., Ginsberg, M.D., Bazan, N.G.Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. Stroke(2005) 36:118-123.

Mukherjee, P.K., Marcheselli, V.L., Serhan, C.N., Bazan, N.G.Neuroprotectin D1: A docosahexanoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci, USA (2004) 101:8491-8496.

Ottino, P., Finley, J., Rojo, E., Ottlecz, A., Lambrou, G.N., Bazan, H.E., Bazan, N.G. Hypoxia activates matrix metalloproteinase expression and the VEGF system in monkey choroid-retinal endothelial cells. Involvement of cytosolic phospholipase A(2) activity. Mol Vis (2004) 10:341-350.

Zhu, P., DeCoster, M.A., Bazan, N.G. Interplay among platelet-activating factor, oxidative stress, and group I metabotropic, glutamate receptors modulates neuronal survival. J Neurosci Res (2004) 77:525-531.

Cui, J.G., Kuroda, H., Chandrasekharan, N.V., Pelaez, R.P., Simmons, D.L., Bazan, N.G., Lukiw, W. J. Cyclooxygenase-3 gene expression in Alzheimer hippocampus and in stressed human neural cells. Neurochem Res(2004) 29:1731-1737.

Rollin, S., Lemieux, C., Maliba, R., Favier, J., Villeneuve, L.R., Allen, B.G., Soker, S., Bazan, N.G., Merhi, Y., Sirois, M.G. VEGF-mediated endothelial P-selectin translocation: Role of VEGF receptors and endogenous PAF synthesis. Blood(2004) 103:3789-3797.

Axelrad, T.W., Deo, D.D., Ottino, P., Van Kirki, J., Bazan, N.G., Bazan, H.E.P., Hunt, J.D. Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration.FASEB J (2004) 18:568-570.

Deo, D.D., Bazan, N.G., Hunt, J.D. Activation of platelet-activating factor (PAF) receptor-coupled Ga q leads to stimulation of Src and focal adhesion kinase (FAK) via two separate pathways in human umbilical vein endothelial cells (HUVEC). J Biol Chem 279:3497-3508, 2004.

Ma, X., Ottino, P., Bazan, H.E., Bazan, N.G. Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells.  Invest Ophthalmol Vis Sci. (2004)45:2915-2921.

Kolko, M., Christoffersen, N.R., Barreiro, S.G., Bazan, N.G.Expression and location of mRNAs encoding multiple forms of secretory phospholipase A 2 in the rat retina. J Neurosci Res (2004) 77:517-524.

Katsura, K., Rodriguez de Turco, E.B., Siesjö, B.K., Bazan, N.G. Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. Brain Res(2004) 1030:133-140.

Tu, B., Bazan, N.G. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenases-2 expression in neocortex. Exp. Neurol. (2003) 179:167-175.

Cortina, M.S., Gordon, W.C., Lukiw, W.J., Bazan, N.G. DNA repair in photoreceptor survival. Mol Neurobiol(2003) 28:111-122 (Review).

McDermott, C., LaHoste, G.J., Chen, C., Musto, A., Bazan, N.G., Magee, J.C. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci(2003) 23:9687-9695.

Marcheselli, V.L., Hong, S., Lukiw, W.J., Tian, X.H., Gronert, K., Musto, A., Hardy, M., Gimenez, J.M., Chiang, N., Serhan, C.N., Bazan, N.G. Novel docosanoids inhibit brain ischema-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem (2003) 278:43807-43817.

Bazan, N.G. Synaptic lipid signaling: Significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res(2003) 44:2221-2233.

Lukiw, W.J., Ottlecz, A., Lambrou, G., Grueninger, M., Finley, J., Thompson, H.W., Bazan, N.G. Coordinate activation of HIF-1 and NF-KappaB DNA binding and COX-2 and VEGF expression in retinal cells by hypoxia. Investi Ophthalmol and Vis Sci(2003) 44:4163-4170.

Chen, C., Bazan, N.G.Acetaminophen modifies hippocampal synaptic plasticity via a presynaptic 5-HT 2 receptor. NeuroReport(2003) 14:743-747.

Kolko, M., Rodriguez de Turco, E.B., Diemer, N.H., Bazan, N.G. Neuronal damage by secretory phospholipase A2: Modulation of cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. Neurosci Lett(2003) 338:164-168.

Bazan, N.G. and Flower, R.J. Lipid signals in pain control. Nature (2002) 420:135-138. (News and Views).

Bazan, N.G. and Lukiw, W.J. Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1 beta and amyloid-beta 42 peptide is potentiated by hypoxia in primary human neural cells. J Biol Chem(2002) 277:30359-30367.

Gordon, W.C., Casey, D.M., Lukiw, W.J., Bazan, N.G. DNA damage and repair in light-induced photoreceptor degeneration. Invest Ophthalmol Vis Sci(2002) 43:3511-3521.

Rodriguez de Turco, E.B., Belayev, L., Liu, Y., Busto, R., Parkins, N., Bazan, N.G., Ginsberg, M.D. Systemic fatty acid responses to transient focal cerebral ischemia: Influence of neuroprotectant therapy with human albumin. J Neurochem(2002) 82:1-10.

DeCoster, M.A., Lambeau, G., Lazdunski, M., Bazan, N.G. Secreted phospholipase A 2 potentiates glutamate-induced calcium increase and cell death in primary neuronal cultures. J Neurosci Res (2002) 67:634-645.

Rodriguez de Turco, E.B., Jackson, F.R., DeCoster, M.A., Kolko, M., Bazan, N.G. Glutatmate signaling and secretory phospholipase A 2 modulate the release of arachidonic acid from neuronal membrane. J Neurosi Res(2002) 68:558-567.

Teather, L.A., Packard, M.A., Bazan, N.G. Post-training cyclooxygenase-2 (COX) inhibition impairs memory consolidation. Learning and Memory(2002) 9:41-47.

Deo, D.D., Axelrad, T.W., Robert, E.G., Marcheselli, V.L., Bazan, N.G, Hunt, J.D. Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells: Evidence for a dual kinase mechanism. J Biol Chem (2002) 277:21237-21245.

Parker, M.A., Bazan, H.E.P., Marcheselli, V.L., Rodriguez de Turco, E.B., Bazan, N.G. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J Neurosci Res (2002) 68:39-50.

Chen, C., Magee, J.C., Bazan, N.G. Cyclooxygenase-2 regulates prostaglandin E 2 signaling in hippocampal long- term synaptic plasticity. J Neurophysiol(2002) 87:2851-2857.

Kolko, M., Nielsen, M., Bazan, N.G., Diemer, N. Secretory phospholipase A 2 induces delayed neuronal COX-2 expression as compared to glutamate. J Neurosci Res (2002) 69:169-177.

Bazan, N.G., Tu, B., Rodriguez de Turco, E.B. What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. Prog Brain Res(2002) 135:175-185, (Review).

Rodriguez de Turco, E.B., Tan, W., Tophan, M.K., Sakane, F., Marcheselli, V.L., Chen, C., Taketomi, A., Prescott, S., Bazan, N.G. Diacylglycerol kinase epsilon regulates seizures susceptibility and long term potentiation through inositol lipid signaling. Proc Natl Acad Sci(2001) 98:4740-4745.

Bazan, N.G.COX-2 as a multifunctional neuronal modulator. Nature Medicine(2001) 7:414-415, (News and Views).

Chen, C., Magee, J.C., Marcheselli, V.L., Hardy, M., Bazan, N.G. Attenuated long-term potentiation in hippocampal dentate gyrus neurons of mice deficient in the platelet-activating factor receptor. J Neurophysiol(2001) 85:384-390.

Lukiw, W.J., Carver, L.A., LeBlanc, H.J., Bazan, N.G. Analysis of 1184 gene transcript levels in Alzheimer CA1 hippocampus: synaptic signaling and transcription factor deficits and upregulation of pro-inflammatory pathways. Alzheimer’s Reports(2000) 3:143-149.

Lukiw, W.J., Rogaev, E.I., Bazan, N.G. Potential of transcriptional coordination of nine genes associated with Alzheimer’s disease. Alzheimer’s Reports(2000) 3:231-242.

Ershov, A.V., Bazan, N.G. Photoreceptor phagocytosis selectively activates PPARa expression in retinal pigment epithelial cells. J Neurosci Res(2000) 60:328-337.

Bazan, N.G. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochem. Biophys. Acta 218:1-10, 1970. Selected as "This Week's Citation Classic" (1991).

PDF with links for Dr. Bazan's publications 1963 to 2012